Antihypertensive effect of extracts from &lt;i&gt;Crateva adansonii&lt;/i&gt; DC.ssp. &lt;i&gt;adansonii&lt;/i&gt; in the Wistar rats

Adjagba, Marius; Awede, Bonaventure; Osseni, Razack; Hountondji, Cyriaque; Dougnon, Godfried; Lagnika, Latifou; Darboux, R.; Laleye, Anatóle

doi:10.4314/ijbcs.v11i6.5

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…The aqueous decoction is the method used by healers to prepare herbal recipes. It is also the most widely used method for the preparation of recipes used in the traditional management of hypertension [21,22]. This technique has therefore been used to carry out the aqueous extraction of the plant drug.…”

Section: Discussionmentioning

confidence: 99%

Effect of fractions from Carissa edulis (Forssk.) Vahl (Apocynaceae) leaves on hypertension induced in Wistars rats

Adjagba¹,

Osseni²,

Adounkpe³

et al. 2022

World J. Adv. Res. Rev.

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High blood pressure is an important health problem because of its prevalence and its several complications. The high cost of its management and the side effects of conventional drugs have led patients to use medicinal plants. Carissa edulis is one of the plants used in the traditional management of hypertension. The aim of this study was to determine the effects of crude extract and fractions of Carissa edulis in L-NAME hypertension rats models. The phytochemical analysis of the extracts was carried out by using the thin layer chromatography method. The pharmacological effect was evaluated in Wistar rats rendered hypertensive by administering the N (ω) -Nitro-L-Arginine-Methyl Ester (L-NAME). The crude extract was administered at 500 mg / kg (b/w) and the fractions at 20 mg / kg (b/w). Blood pressure was measured by a non-invasive method. Four fractions were obtained after fractionation. Many chemical compounds were detected diversely distributed in either in the crude extract or in the fractions. The crude aqueous extract induced a significant decrease in blood pressure from 137, 00 ± 8,01 mmHg to 94,75 ± 2.84 mmHg. In the other hand, only the aqueous fraction exerted the highest effects by reducing the blood pressure from 137,00 ± 8,01 mmHg to 93,5±8,54 mmHg.

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Section: Discussionmentioning

confidence: 99%

Effect of fractions from Carissa edulis (Forssk.) Vahl (Apocynaceae) leaves on hypertension induced in Wistars rats

Adjagba¹,

Osseni²,

Adounkpe³

et al. 2022

World J. Adv. Res. Rev.

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“…In Togo, the plant is consumed as a legume and traditionally used to treat diseases such as abscesses, wounds, bacterial infections, rheumatism and diabetes. Previously studies have reported antimicrobial, anticancer, antiparasitic, analgesic, antioxidant, antidiabetic and antihypertension activities of C. adansonii [5,6] . Despite the widespread use of C. adansonii, scientific data on its antidiabetic properties are very paucity.…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycaemic and antioxidant activities of Crataeva adansonii DC. ssp. adansonii leaves extract on ICR mice

Atchou¹,

Lawson-Evi²,

Metowogo³

et al. 2020

J. Drug Delivery Ther.

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Crataeva adansonii DC. ssp. adansonii is a medicinal plant belong to Capparidaceae family, used traditionally by Togolese to treat diabetes mellitus. The aim of this study was to evaluate the antihyperglycaemic and antioxidant activities of the plant leaves. The effect of hydroethanolic extract of C. adansonii ssp. adansonii leaves was assessed in vivo on blood glucose levels in fasting normal and glucose loaded hyperglycemic (oral glucose tolerance test) mice. The phytochemical screening has been done by coloring tests in chemistry. In vitro antioxidants assays had been performed by 2, 2'-azobis 2 amidinopropane dihydrochloride (AAPH) free radical scavenging assay, Ferric reducing antioxidant power (FRAP) assay, Fe2+ chelating assay and total antioxidant capacity (TAC) quantification. After 30 min glucose loading (4 g/kg), the extract 500 mg/kg was showed a significant (p < 0.001) decreased of the peak of blood glucose compared to the hyperglycemic control. The two doses of extract (250 and 500 mg/kg) did not act on the basic blood glucose compared to the normoglycemic control. Phytochemical screening revealed a presence of flavonoids, tannins, alkaloids and sterols. AAPH free radical scavenging activity, reducing power, Fe2+ chelating activity and total antioxidant capacity have shown dose-dependent antioxidant capacity and reducing power of extract compared to ascorbic acid and Butylated hydroxyl Toluene used as reference drug. These finding prove that C. adansonii ssp. adansonii leaves can be used in the treatment of diabetes mellitus and its complications related to oxidative stress and support the use of the plant in traditional medicine in diabetes treatment. Keywords: Crataeva adansonii, antihyperglycaemic, phytochemical, antioxidant.

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“…Use of C. adansonii against bronchitis, calculi, asthma, cough, renal and urinary troubles, dyspepsia and uterine infections is also well known in traditional medicine (Kumar et al, 2012;Gitte et al, 2012). Previously anticancer, antimicrobial, antihypertension, analgesic, antiparasitic, antidiabetic and antioxidant activities of C. adansonii have been reported (Zingue et al, 2016;Adjagba et al, 2017). Cytotoxic studies have been carried out in various genera of the family Capparaceae including C. nurvala (Sinha et al, 2013;Ali et al, 2014;Hade et al, 2016;Parvin et al, 2011) and C. nurvala (Da Silva Ferreira et al, 2013).…”

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confidence: 99%

Fluorescence Analysis, Extractive Values and Cytotoxic Screening of Crataeva adansonii DC Leaf and Bark through Brine Shrimp Larvae Assay

Bibi¹,

Din²

2020

SJA

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C rataeva adansonii is a moderate-sized deciduous tree belonging to family Capparaceae (Ryan and Ray, 2004). It is commonly known as Varun, temple plant and sacred garlic pear. It grows well on sandy loam in arid areas. In Pakistan, it is found on the Sub-Himalayan track. Its leaves are trifoliate compound (Figure1; Hoang, 2013). The fruit is globose in shape having a 4-5cm diameter. The flowers are showy Abstract | Crataeva adansonii is a medicinal plant and many folklore uses of this plant are well known to us. Pharmacognostic studies like finding extractive values and nutritional values play a vital role in the determination of adulterated or exhausted drugs. It lays down parameters for authentication and standardization of drugs. The cytotoxic study helps in the evaluation of a drug for its toxicity, which is determined by the prevention of growth and replication. Such drugs can be used to treat cancer, multiple sclerosis and rheumatoid arthritis. During the present study ethanolic extracts of leaf and bark parts of C. adansonii were evaluated through cytotoxic activity. Brine shrimp larvae assay was conducted for this purpose. Extractive values of leaf and bark parts were estimated using n-hexane, chloroform, ethanol, methanol, water, and ether as a solvent. 10g of plant powder was dissolved in 200 ml solvent during various extract preparations Fluorescence study was conducted after treating the powder drug with different reagents including ethanol, methanol, acetic acid, n-hexane, HCl, nitric acid, carrageenan, glacial acetic acid, diethyl ether and picric acid and change in coloration was observed. Distinct fluorescence was exhibited by the drug under the normal daylight and UV-radiations of short wavelength (256nm) and long wavelength (365nm). Both the leaf and bark parts showed maximum extractive values in water (23% and 15% respectively) followed by methanol (15% and 6% respectively. The leaf part showed greater extractive values as compared to the bark. The cytotoxic study revealed that the ethanolic extract crude drugs of each part dose-dependently exhibited cytotoxic activity. At higher concentration (100-1000 µg/ml) the leaf and bark ethanolic extracts showed cytotoxicity and at lower concentration (10 µg/ml) very low cytotoxic effect was observed (Figure 4). The LC 50 values for crude leaf extract were found to be 5.34 and for that of stem bark extract, it was 7.44 ug/ml. This study manifests that the selected plant can be helpful in the preparation of novel pharmaceuticals. The pharmacognostic evaluation of this important medicinal drug will be supportive in the detection of adulteration and drug quality control.

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Antihypertensive effect of extracts from <i>Crateva adansonii</i> DC.ssp. <i>adansonii</i> in the Wistar rats

Cited by 6 publications

References 5 publications

Effect of fractions from Carissa edulis (Forssk.) Vahl (Apocynaceae) leaves on hypertension induced in Wistars rats

Effect of fractions from Carissa edulis (Forssk.) Vahl (Apocynaceae) leaves on hypertension induced in Wistars rats

Antihyperglycaemic and antioxidant activities of Crataeva adansonii DC. ssp. adansonii leaves extract on ICR mice

Fluorescence Analysis, Extractive Values and Cytotoxic Screening of Crataeva adansonii DC Leaf and Bark through Brine Shrimp Larvae Assay

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