Antihypertensive Effect of 5-HT&lt;sub&gt;1A&lt;/sub&gt; Agonist Buspirone and 5-HT&lt;sub&gt;2B&lt;/sub&gt; Antagonists in Experimentally Induced Hypertension in Rats

Shingala, J.R.; Balaraman, R

doi:10.1159/000082114

Cited by 16 publications

(9 citation statements)

References 43 publications

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“…That led to decrease in SBP[45] and improve diastolic function in the left ventricle, which led to decrease in DBP. [46] Bu as reported by Shingala and Balaraman, 2005,[4] has an antihypertensive effect through aortic effect and vascular activity (DBP) Furthermore, it was reported that Bu reduced the SBP. [47]…”

Section: Resultsmentioning

confidence: 98%

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Development and evaluation of fixed dose bi therapy sublingual tablets for treatment stress hypertension and anxiety

et al. 2013

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Objective:A stress induced rise in the blood pressure. Some believe that patients with hypertension are characterized by a generalized state of increased anxiety.Aim:The purpose of this study is to prepare a fixed dose bi therapy using bisoprolol hemifumarate (BH) as antihypertensive drug and buspirone hydrochloride (BuHCl) as anxiolytic drug, which can be used to treat both diseases concomitantly. Using sublingual tablets is hopeful to improve the BuHCl poor oral bioavailability and to facilitate administration to patients experiencing problems with swallowing.Materials and Methods:A total of 5mg BH and 10mg BuHCl were selected based on compatibility study. A 3×22 full factorial design was adopted for the optimization of the tablets prepared by direct compression method. The effects of the filler type, the binder molecular weight, and the binder type were studied. The prepared formulae were evaluated according to their physical characters as hardness, friability, disintegration time (new modified method and in vivo disintegration time) and wetting properties. In vitro drugs dissolute, permeation through the buccal mucosa and the effect of storage were analyzed by a new valid high pressure liquid chromatography (HPLC) method. Bioavailability study of the selected formula study was carried out and followed by the clinical.Results:The optimized tablet formulation showed accepted average weight, hardness, wetting time, friability, content uniformity, disintegration time (less than 3 min). Maximum drug release could be achieved with in 10 min. In addition enhancing drug permeation through the buccal mucosa and, the maximum concentration of the drug that reached the blood was in the first 10 min which means a rapid onset of action and improved the extent of both drug's absorption.Conclusion:The results revealed that sublingual (F6) tablets containing both drugs would maintain rapid onset of action, and increase bioavailability. BuHCl with BH can be attributed to the marked decline in DBP and SBP. That led to a reduction in the MAP.

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Section: Resultsmentioning

confidence: 98%

“…They reduced the mean arterial pressure (MAP) through decreasing the BP and reducing the cardiovascular responses to the 5-HT1A receptor agonists. [4]…”

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confidence: 99%

Development and evaluation of fixed dose bi therapy sublingual tablets for treatment stress hypertension and anxiety

et al. 2013

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“…However, conflicting reports by Hanson et al [30], Taylor et al [31], and Unrug et al [32] suggest a decrease in mean arterial blood pressure and HR. Further, it has also been reported that chronic administration of buspirone in DOCA induced hypertensive rats significantly reduces BP and 5-HT1A agonists might possess antihypertensive action [33]. The effect of buspirone on CVS functions seems to be dependent on species, route, and dose [30].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications

Raghunathan

Tank

Bhadada

et al. 2014

BioMed Research International

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We have evaluated the effect of buspirone (1.5 mg/kg/day, p.o.) type 1 diabetes induced cardiovascular complications induced by streptozotocin (STZ, 45 mg/kg, i.v.) in Wistar rats. Various biochemical, cardiovascular, and hemodynamic parameters were measured at the end of 8 weeks of treatment. STZ produced significant hyperglycaemia, hypoinsulinemia, and dyslipidemia, which was prevented by buspirone treatment. STZ produced increase in serum creatinine, urea, lactate dehydrogenase, creatinine kinase, and C-reactive protein levels and treatment with buspirone produced reduction in these levels. STZ produced increase in cardiac and LV hypertrophy index, LV/RV ratio, and LV collagen, which were decreased by buspirone treatment. Buspirone also prevented STZ induced hemodynamic alterations and oxidative stress. These results were further supported by histopathological studies in which buspirone showed marked reduction in fibrosis and cardiac fiber disarray. In conclusion, our data suggests that buspirone is beneficial as an antidiabetic agent in type 1 diabetes mellitus and also prevents its cardiac complications.

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“…The same procedure was followed in rats, except the tightening and the releasing of the cannula were considered as Sham operated animals. The carotid artery was cannulated using transducer (SL 13L, Biopac Systems) for measuring the hemodynamic parameters 10 . Parameters like systolic (SBP), diastolic (DBP) and mean arterial blood pressure (MAP) were observed.…”

Section: Myocardial Ischemia/reperfusion Injury Induction By Left Cormentioning

confidence: 99%

Cardioprotective Effect of Banaba on Myocardial Ischemia/Reperfusion Injury in Rats

Dhote¹,

Balaraman²,

Raja

2020

Journal of Natural Remedies

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The ethanol extract of Banaba (Lagerstroemia speciosa L.) leaves, was investigated for their effects on ischemia/reperfusion (I/R) injury induced by occlusion of the left descending coronary artery (LCA) for 1 h, followed by re-opening again for 1 h. Banaba ethanol extract (100 mg/kg) intraperitonially (i.p.) was administered 30 min after induction of ischemia. During I/R period, the hemodynamics and ECG parameters were measured. Oxidative stress markers like reduced glutathione (GSH), Superoxide dismutase (SOD), malondialdehyde (MDA), activities of myeloperoxidase (MPO), creatine kinase (CK) and myocardial infarct area were significantly (P<0.05) reduced in Wistar rats after Banaba treatment. The apoptotic activity and histological observations were influenced by Banaba. The cardioprotective effect of Banaba could be attributed to its ability to improve the antioxidant mechanism, anti-inflammatory and anti-apoptotic activity in ischemic animals.

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Antihypertensive Effect of 5-HT<sub>1A</sub> Agonist Buspirone and 5-HT<sub>2B</sub> Antagonists in Experimentally Induced Hypertension in Rats

Cited by 16 publications

References 43 publications

Development and evaluation of fixed dose bi therapy sublingual tablets for treatment stress hypertension and anxiety

Development and evaluation of fixed dose bi therapy sublingual tablets for treatment stress hypertension and anxiety

Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications

Cardioprotective Effect of Banaba on Myocardial Ischemia/Reperfusion Injury in Rats

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