Antihypertensive drug use and risk of cognitive decline in the very old

Abstract

Findings provide support for an association between CCB use and a lower rate of cognitive decline in very old adults with hypertension.

Drug interactions with dementia‐related pathophysiological pathways worsen or prevent dementia

“…The cohort studies that aimed to assess the effect of AHMs on cognition among cognitively normal patients found a decreased risk of cognitive impairment with calcium channel blockers (CCBs), β‐blockers, angiotensin‐converting enzyme inhibitors (ACE‐Is), and diuretics (Gao et al, ; Gelber et al, ; R. Peters, Collerton, et al, ; Yasar, Zhou, Varadhan, & Carlson, ; Table ). Demir, Gürol, Özyiğit, and Üresin () performed a cross‐sectional study and did not find a difference in the Mini Mental State Examination scores between renin angiotensin system (RAS) blocker users (angiotensin 1 receptors blockers [ARBs] and ACE‐Is) and other AHM users.…”

“…The cohort studies that aimed to assess the effect of AHMs on cognition among cognitively normal patients found a decreased risk of cognitive impairment with calcium channel blockers (CCBs), β-blockers, angiotensin-converting enzyme inhibitors (ACE-Is), and diuretics (Gao et al, 2013;Gelber et al, 2013;R. Peters, Collerton, et al, 2015;Yasar, Zhou, Varadhan, & Carlson, 2008; Table 1).…”

High blood pressure in dementia: How low can we go?

“…Another oldest old study, the Newcastle 85 plus, showed that having high BP defined as SBP/DBP ≥130/85 mm Hg or treatment was associated with better global cognitive function over 5 years . The Vantaa 85 plus study also reported the same result, where lower SBP increased mortality among people aged 85 or more with no significant relationship between baseline BP and dementia occurrence …”

Antihypertension drugs in prevention of cognition disorder and dementia: focus on calcium channel blockers and diuretics

“…Проведен анализ литера-туры (15 наблюдательных исследований и РКИ) за последние 5 лет. В 6 исследованиях были представлены результаты лечения АК [17,18,[42][43][44][45], в 5 из них показана польза использования АК -снижался риск развития когнитивных нарушений или деменции [17,18,42,43,45], в 2 исследованиях результаты достигли статистической значимости -Newcastle 85+ [42] и Veteran's Affairs medical database США [17]. В исследовании Newcastle 85+ приняли участие 238 пациентов в возрасте ≥85 лет с АГ, получающих АГТ.…”

“…В 8 исследованиях изучали применение диуретиков, в 7 из них выявлена польза диуретиков в плане снижения риска развития когнитивных нарушений или деменции [17,18,[42][43][44][45][46], в трех результаты достиг ли статистической значимости: GEMS [18], Cache County [43], Veteran's Affairs medical database, США [17]. Среди последних, в исследованиях GEMS [18] и Cache County [43] показано, что терапия диуретиками статистически значимо снижает риск развития БА [18,43], а в исследовании Veteran's Affairs medical database, США [17] на фоне приема диуретиков обнаружено статистически значимое снижение риска развития деменции [17].…”