Antihypertensive drug therapy for mild to moderate hypertension during pregnancy

Ábalos, Edgardo; Duley, Lelia; Steyn, D.W.; Gialdini, Celina

doi:10.1002/14651858.cd002252.pub4

Cited by 108 publications

(112 citation statements)

References 138 publications

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“…There is indirect evidence (two SRs: Yakoob 2013 49 and Abalos 2018 50 ) that use of any β‐blocker was associated with cardiovascular anomalies, cleft lip/palate, and neural tube defects, but not preterm birth (Moderate SoE).…”

Section: Resultsmentioning

confidence: 99%

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Management of primary headaches during pregnancy, postpartum, and breastfeeding: A systematic review

et al. 2021

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Background: Primary headaches (migraine, tension headache, cluster headache, and other trigeminal autonomic cephalgias) are common in pregnancy and postpartum. It is unclear how to best and most safely manage them. Objective: We conducted a systematic review (SR) of interventions to prevent or treat primary headaches in women who are pregnant, attempting to become pregnant, postpartum, or breastfeeding. Methods: We searched Medline, Embase, Cochrane CENTRAL, CINAHL, ClinicalTrials. gov, Cochrane Database of SRs, and Epistemonikos for primary studies of pregnant women with primary headache and existing SRs of harms in pregnant women regardless of indication. No date or language restrictions were applied. We assessed strength of evidence (SoE) using standard methods. Results: We screened 8549 citations for studies and 2788 citations for SRs. Sixteen studies (mostly high risk of bias) comprising 14,185 patients (total) and 26 SRs met the criteria. For prevention, we found no evidence addressing effectiveness. Antiepileptics, venlafaxine, tricyclic antidepressants, benzodiazepines, β-blockers, prednisolone, and oral magnesium may be associated with fetal/child adverse effects, but calcium channel blockers and antihistamines may not be (1 single-group study and 11 SRs; lowto-moderate SoE). For treatment, combination metoclopramide and diphenhydramine may be more effective than codeine for migraine or tension headache (1 randomized controlled trial; low SoE). Triptans may not be associated with fetal/child adverse effects (8 nonrandomized comparative studies; low SoE). Acetaminophen, prednisolone, indomethacin, ondansetron, antipsychotics, and intravenous magnesium may be associated with fetal/child adverse effects, but low-dose aspirin may not be (indirect evidence; low-to-moderate SoE). We found insufficient evidence regarding non-pharmacologic treatments.

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Section: Resultsmentioning

confidence: 99%

“…There is indirect evidence (one SR: Abalos 2018 50 ) that use of any calcium channel blocker was not associated with maternal (Low SoE) or fetal/child adverse effects (Low to Moderate SoE). There is also indirect evidence (one SR: Bellos 2020a 52 ) that nifedipine was not associated with fetal/child adverse effects (Low to Moderate SoE).…”

Section: Resultsmentioning

confidence: 99%

Management of primary headaches during pregnancy, postpartum, and breastfeeding: A systematic review

et al. 2021

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“…Regardless of the improvement of antihypertensive prescriptions, however, strong BP control was still a notable therapeutic test and there was reliable interest in new and successful therapy. [5] In addition, there are many antihypertensive plant drugs that are needed to discover new chemical structure change. [6] Sulfonamides are one of the popular drug classes used to treat many diseases, according to their functional uses as antihypertensive, anti-bacterial, anti-inflammatory, antibacterial and antifungal agent.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Docking and Antihypertensive Activity of Pyridone Derivatives

Masaret

2020

ChemistrySelect

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A substituted 4-((5-cyano-1-ethyl-2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridin-3-yl)diazenyl)benzene-sulfonamides were picked up via coupling of aromatic Diazonium salt for sulfonamide derivatives on 3-cyano-6-hydroxyl-2-pyridone derivative. The synthesized 4-((pyridinyl)azo)benzene-sulfonamide analogues have been evidenced through elemental and spectral analyses "FT-IR, 1 HNMR, 13 CNMR and MS". The produced derivatives were exposed to molecular docking to predict their antihypertensive activity toward protein databank identification number (PDB ID 6JP5) complexed with an amino acids consequent from the human Voltage-dependent L-type calcium channel (LCC) alpha-1S subunit. The docking studies outcomes endorsed us to utilize these analogues in vivo antihypertensive effectiveness treatise. The Mean systolic blood pressure (SBP) of hypertensive rats injected by Dihydropyridine derivatives (DHPD) were evaluated in comparable with nifedipine that utilized as standard drug. Moreover, the vasorelaxant effectiveness of the synthesized derivatives 7 a-e were examined against the contraction induced by noradrenaline (0.1 mM, NA) on aorta rat rings.

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“…1 Treatment of mild to moderate hypertension results in a 50% decrease in the development of severe hypertension, but no difference in preeclampsia or other outcomes according to a Cochrane systematic review. 17 Conversely, treatment is recommended for severe hypertension (SBP ! 160 mm Hg and/or DBP >105-110 mm Hg) persisting for longer than 15 minutes.…”

Section: Pharmacologic Treatment Optionsmentioning

confidence: 99%