Antihypertensive drug therapy for mild to moderate hypertension during pregnancy

Less-Tight Versus Tight Control of Hypertension in Pregnancy

“…Our trial is substantially larger than previous trials that have examined the effects of lower versus higher blood-pressure targets during pregnancy (with previous trials having randomly assigned women to antihypertensive therapy or placebo or no treatment). 5 With respect to the mothers, our findings are consistent with a metaanalysis of previous trials (29 trials involving 3350 women) that showed that less-tight versus tight control increases the incidence of severe maternal hypertension (but not preeclampsia). 5 Severe hypertension is a risk factor for acute stroke during and outside of pregnancy.…”

“…5 With respect to the mothers, our findings are consistent with a metaanalysis of previous trials (29 trials involving 3350 women) that showed that less-tight versus tight control increases the incidence of severe maternal hypertension (but not preeclampsia). 5 Severe hypertension is a risk factor for acute stroke during and outside of pregnancy. 15,21 The rates of severe hypertension were higher in the current study than in some previous trials (in which the rate was approximately 20% in the placebo or no-therapy group), 5 even though almost half the women in CHIPS performed blood-pressure moni-toring at home.…”

Less-Tight Versus Tight Control of Hypertension in Pregnancy

“…Our trial is substantially larger than previous trials that have examined the effects of lower versus higher blood-pressure targets during pregnancy (with previous trials having randomly assigned women to antihypertensive therapy or placebo or no treatment). 5 With respect to the mothers, our findings are consistent with a metaanalysis of previous trials (29 trials involving 3350 women) that showed that less-tight versus tight control increases the incidence of severe maternal hypertension (but not preeclampsia). 5 Severe hypertension is a risk factor for acute stroke during and outside of pregnancy.…”

“…5 With respect to the mothers, our findings are consistent with a metaanalysis of previous trials (29 trials involving 3350 women) that showed that less-tight versus tight control increases the incidence of severe maternal hypertension (but not preeclampsia). 5 Severe hypertension is a risk factor for acute stroke during and outside of pregnancy. 15,21 The rates of severe hypertension were higher in the current study than in some previous trials (in which the rate was approximately 20% in the placebo or no-therapy group), 5 even though almost half the women in CHIPS performed blood-pressure moni-toring at home.…”

Differentiating between gestational and chronic hypertension; an explorative study

“…The use of acetylsalicylic acid in 72% of women might have influenced the incidence of PE to some degree. In line with reported meta‐analytical data, it may be that both the tight antihypertensive control and low threshold to start antihypertensive medication with sympaticolytic agents, especially labetalol [which was shown to reduce the risk for preeclampsia by 27% (95% confidence interval 6–43%)] and the use of preventive medication, affected our low hypertensive complication rates .…”

Hypertension in Pregnancy: A Diagnostic and Therapeutic Overview

“…Most women included in this study had non-severe and non-proteinuric chronic hypertension (75%, 736 out of 987) and 25% had gestational hypertension. Similar to previous meta-analyses [ 39 , 40 ], the development of severe hypertension was significantly reduced in the “more tight” arm of the study. In the subgroup of women with chronic hypertension, “less tight” BP control was associated with lower rates of small-for-gestational age newborns.…”

Less-Tight Versus Tight Control of Hypertension in Pregnancy

“…Our trial is substantially larger than previous trials that have examined the effects of lower versus higher blood-pressure targets during pregnancy (with previous trials having randomly assigned women to antihypertensive therapy or placebo or no treatment). 5 With respect to the mothers, our findings are consistent with a metaanalysis of previous trials (29 trials involving 3350 women) that showed that less-tight versus tight control increases the incidence of severe maternal hypertension (but not preeclampsia). 5 Severe hypertension is a risk factor for acute stroke during and outside of pregnancy.…”

“…5 With respect to the mothers, our findings are consistent with a metaanalysis of previous trials (29 trials involving 3350 women) that showed that less-tight versus tight control increases the incidence of severe maternal hypertension (but not preeclampsia). 5 Severe hypertension is a risk factor for acute stroke during and outside of pregnancy. 15,21 The rates of severe hypertension were higher in the current study than in some previous trials (in which the rate was approximately 20% in the placebo or no-therapy group), 5 even though almost half the women in CHIPS performed blood-pressure moni-toring at home.…”

Differentiating between gestational and chronic hypertension; an explorative study

“…The use of acetylsalicylic acid in 72% of women might have influenced the incidence of PE to some degree. In line with reported meta‐analytical data, it may be that both the tight antihypertensive control and low threshold to start antihypertensive medication with sympaticolytic agents, especially labetalol [which was shown to reduce the risk for preeclampsia by 27% (95% confidence interval 6–43%)] and the use of preventive medication, affected our low hypertensive complication rates .…”

Hypertension in Pregnancy: A Diagnostic and Therapeutic Overview

“…Most women included in this study had non-severe and non-proteinuric chronic hypertension (75%, 736 out of 987) and 25% had gestational hypertension. Similar to previous meta-analyses [ 39 , 40 ], the development of severe hypertension was significantly reduced in the “more tight” arm of the study. In the subgroup of women with chronic hypertension, “less tight” BP control was associated with lower rates of small-for-gestational age newborns.…”

Less-Tight Versus Tight Control of Hypertension in Pregnancy

“…Our trial is substantially larger than previous trials that have examined the effects of lower versus higher blood-pressure targets during pregnancy (with previous trials having randomly assigned women to antihypertensive therapy or placebo or no treatment). 5 With respect to the mothers, our findings are consistent with a metaanalysis of previous trials (29 trials involving 3350 women) that showed that less-tight versus tight control increases the incidence of severe maternal hypertension (but not preeclampsia). 5 Severe hypertension is a risk factor for acute stroke during and outside of pregnancy.…”

“…5 With respect to the mothers, our findings are consistent with a metaanalysis of previous trials (29 trials involving 3350 women) that showed that less-tight versus tight control increases the incidence of severe maternal hypertension (but not preeclampsia). 5 Severe hypertension is a risk factor for acute stroke during and outside of pregnancy. 15,21 The rates of severe hypertension were higher in the current study than in some previous trials (in which the rate was approximately 20% in the placebo or no-therapy group), 5 even though almost half the women in CHIPS performed blood-pressure moni-toring at home.…”

Differentiating between gestational and chronic hypertension; an explorative study

“…The use of acetylsalicylic acid in 72% of women might have influenced the incidence of PE to some degree. In line with reported meta‐analytical data, it may be that both the tight antihypertensive control and low threshold to start antihypertensive medication with sympaticolytic agents, especially labetalol [which was shown to reduce the risk for preeclampsia by 27% (95% confidence interval 6–43%)] and the use of preventive medication, affected our low hypertensive complication rates .…”

Hypertension in Pregnancy: A Diagnostic and Therapeutic Overview

“…Most women included in this study had non-severe and non-proteinuric chronic hypertension (75%, 736 out of 987) and 25% had gestational hypertension. Similar to previous meta-analyses [ 39 , 40 ], the development of severe hypertension was significantly reduced in the “more tight” arm of the study. In the subgroup of women with chronic hypertension, “less tight” BP control was associated with lower rates of small-for-gestational age newborns.…”