Antihypertensive and Cardiovascular Effects of Catechin-Rich Oil Palm (<i>Elaeis guineensis</i>) Leaf Extract in Nitric Oxide–Deficient Rats

Jaffri, Juliana Md.; Mohamed, Suhaila; Rohimi, Nordanial; I, Ahmad; Noordin, M. M.; Manap, Yazid Abdul

doi:10.1089/jmf.2010.1170

Cited by 34 publications

(52 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The palm leaves have been used for decades as ruminant feed without any reports of toxicity. The oil palm (Elaeis guineensis) leaves methanolic extract (OPLE) are rich in flavonoids and green tea catechins (Jaffri et al, 2011). The OPLE decreased coronary arteriole wall-lumen ratio to near normal values, and showed good cardio-protective effects under NO deficiency (Jaffri et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver

Jaffri

Mohamed

et al. 2011

Food Chemistry

Self Cite

View full text Add to dashboard Cite

Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation, antioxidant and cardiovascular properties. This study evaluated the beneficial or toxic effects of OPLE on the liver and kidneys of normal and hypertensive rats. The OPLE (500mg/kg body weight) were administered orally to normal Wistar Kyoto rats, spontaneously hypertensive rats (SHR) and N-ω-nitro-l-arginine methyl ester (l-NAME)-induced NO-deficient hypertensive rats. The OPLE reduced hypertension in NO-deficient rats, but not in SHR. Hepatocytes or glomeruli injury and oxidative markers were high in hypertensive rats compared to normal rats, and they were reduced (p<0.05) by OPLE supplementation, even when there was no blood pressure reduction. Unlike the hypertensive drug captopril, the OPLE showed no toxicity to normal rats. The dose reported is equivalent 0.5g of catechins/day for humans or 2.5cups of tea. The catechins are from an abundant alternative source for potential use as functional food.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver

Jaffri

Mohamed

et al. 2011

Food Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…It also effectively inhibited low-density lipoprotein oxidation better than other edible plant extracts (Salleh et al, 2002). Also, in a 12-week study conducted by Jaffri et al (2011) on rats, the leaf extract showed good anti-hypertensive and anti-oxidant effects under NO deficiency, it was not hypotensive to normal rats and produced no chronic cardiovascular toxicity in any of the rats throughout the study. Sasidharan et al (2009) demonstrated the hepatoprotective effects of E. guineensis against paracetamol induced liver damage by looking at the histopathology of mice liver.…”

Section: Cardiovascualar Activitiesmentioning

confidence: 85%

“…E. guineensis is rich in catechins and polyphenols (Jaffri, 2011). Prior studies in streptozotocin-induced hyper glycemic rats showed that E. guineensis improved proteinuria and reduced oxidative stress levels (Rosalina Yamabe, 2006).…”

Section: Anti-diabetic Actionmentioning

confidence: 99%

“…Methanolic oil palm (Elaeis guineensis) leaf extract is rich in polyphenols (Runnie et al, 2003;Jaffri, 2011).The methanolic leaf extract of E. guineensis has also been shown to possess anti-cancer activities . Studies have observed the presence of a large number of bioactive compounds in the methanolic extracts of this plant TANG / www.e-tang.org 2014 / Volume 4 / Issue 3 / e16 including tannins, alkaloids, steroids, saponins, terpenoids, and flavonoids which exhibit various biological activities Gulecha and Sivakuma, 2011;Kumar et al, 2011).…”

Section: Anti-cancer Activitiesmentioning

confidence: 99%

See 1 more Smart Citation

Traditional oil palm (Elaeis guineensis jacq.) and its medicinal uses: A review

Owoyele¹,

Owolabi²

2014

TANG [HUMANITAS MEDICINE]

View full text Add to dashboard Cite

The oil palm (Elaeis guineensis Jacq.) has been reported to originate along the gulf of the guinea in West Africa. The various parts of the tree have been used locally and traditionally for various medicinal purposes. Some of these uses have been proved by scientific experiments. Palm oil is extracted from the mesocarp of the fruit and is used traditionally for the treatment of headaches, pains, rheumatism, cardiovascular diseases, arterial thrombosis and an atherosclerosis due to its rich phytonutrients. The leaves are also used for the treatment of cancer, cardiovascular diseases, kidney diseases and wound healing. The sap also has been found to be rich in phytonutrients that can be used to treat various diseases. This review therefore seeks to explore many of the uses of the oil palm using the various parts of the oil palm.

show abstract

“…Indeed, catechin has anti-hypertensive proprieties [38]. According to results by TLC, only samples of leaves from both morph (EII and EIV) contained Catechin.…”

Section: Liver Ischemia-reperfusionmentioning

confidence: 98%

Effect of Myrtus Communis L. Extracts on Attenuation of Liver Normothermic Ischemia-Reperfusion Injury

Ferchichi¹

2012

J Transplant Technol

View full text Add to dashboard Cite

The Common Myrtle (Myrtus communis L.) is rich in antioxidants, particularly in anthocyanin. It was recognized for its anti-inflammatory and anti-thrombotic effects.The aim of our work is to evaluate the effect of Common Myrtle on a model of hepatic ischemia-reperfusion in Rat.Two morphs were chosen: white fruit Myrtle and black fruit Myrtle. Within each morph, fruit and leaf were separated and obtained extract were used to determine their effects on the hepatic model of ischemia-reperfusion.Our work was conducted in three steps (1) Induction of hepatic ischemia (90 minutes) in Wistar Rat (2) injection of the Myrtle extract during 15 minutes before reperfusion (3) and reperfusion (2 hours).To evaluate the effect of Myrtle on ischemia-reperfusion, we have monitored transaminases levels, Monoethylglycinexylidide (MEGX) concentrations (to assess the liver metabolic capacity) and Malondialdehyde (MDA) concentration.The determination of total phenol extracts of Myrtle showed a significant difference between black fruit Myrtle (11.3 µg/ml), white fruit (27 µg/ml) and black fruit Myrtle leaves (94.3 µg/ml). The latter presented the highest antioxidant activity (86.54%).With the extract from the white fruit of Myrtle, we noted a decrease of AST and ALT, respectively, 1321 U/I and 773 U/I compared with I/R group was 5757 U/I and 5404 U/I and an increase in the MEGX concentrations and decrease in MDA.The testing of extracts of Myrtle in a model of hepatic ischemia showed a difference in the protective power against damage of ischemia-reperfusion, by origin and type of fruit (black or white).

show abstract

Antihypertensive and Cardiovascular Effects of Catechin-Rich Oil Palm (Elaeis guineensis) Leaf Extract in Nitric Oxide–Deficient Rats

Cited by 34 publications

References 40 publications

Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver

Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver

Traditional oil palm (Elaeis guineensis jacq.) and its medicinal uses: A review

Effect of Myrtus Communis L. Extracts on Attenuation of Liver Normothermic Ischemia-Reperfusion Injury

Contact Info

Product

Resources

About