Antihyperlipidemic potential of diosmin in Swiss Albino mice with high-fat diet induced hyperlipidemia

Firdous, Sayeed Mohammed; Hazra, Sayan; Gopinath, Subash C.B.; El-Desouky, Gaber E.; Aboul‐Soud, Mourad A. M.

doi:10.1016/j.sjbs.2020.08.040

Cited by 9 publications

(7 citation statements)

References 38 publications

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“…In T1D and T2D patients, lipid control appears to be important in the prevention and treatment of macro- and microvascular complications, including DN [ 42 , 43 ]. Previous reports have described the antihyperlipidemic potential of different flavonoids in experimental models of cardiovascular disease [ 44 , 45 ]. Likewise, we suggest that hidrosmin could be tested as coadjutant therapy with the current lipid-lowering drugs to reduce cardiovascular risk and delay the progression of DN.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy

et al. 2021

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Diabetes mellitus (DM) is a high-impact disease commonly characterized by hyperglycemia, inflammation, and oxidative stress. Diabetic nephropathy (DN) is a common diabetic microvascular complication and the leading cause of chronic kidney disease worldwide. This study investigates the protective effects of the synthetic flavonoid hidrosmin (5-O-(beta-hydroxyethyl) diosmin) in experimental DN induced by streptozotocin injection in apolipoprotein E deficient mice. Oral administration of hidrosmin (300 mg/kg/day, n = 11) to diabetic mice for 7 weeks markedly reduced albuminuria (albumin-to-creatinine ratio: 47 ± 11% vs. control) and ameliorated renal pathological damage and expression of kidney injury markers. Kidneys of hidrosmin-treated mice exhibited lower content of macrophages and T cells, reduced expression of cytokines and chemokines, and attenuated inflammatory signaling pathways. Hidrosmin treatment improved the redox balance by reducing prooxidant enzymes and enhancing antioxidant genes, and also decreased senescence markers in diabetic kidneys. In vitro, hidrosmin dose-dependently reduced the expression of inflammatory and oxidative genes in tubuloepithelial cells exposed to either high-glucose or cytokines, with no evidence of cytotoxicity at effective concentrations. In conclusion, the synthetic flavonoid hidrosmin exerts a beneficial effect against DN by reducing inflammation, oxidative stress, and senescence pathways. Hidrosmin could have a potential role as a coadjutant therapy for the chronic complications of DM.

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Section: Discussionmentioning

confidence: 99%

Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy

et al. 2021

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“… 27 Hyperlipidemia is a major risk factor for CVD such as atherosclerosis, coronary artery disease, and acute myocardial infarction, so effective medical treatment needs to be developed as soon as possible. 28 The research and development of lipid-lowering drugs is a field worthy of in-depth research. Fucoidan, as a natural active polysaccharide, has a variety of pharmacological activities, and its lipid-lowering effects have been widely discussed.…”

Section: The Hypolipidemic Effects Of Fucoidanmentioning

confidence: 99%

Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases

Wang

Xu²,

Wei

et al. 2022

Therapeutic Advances in Chronic Disease

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Fucoidan is a marine polysaccharide. In recent years, fucoidan has attracted wide-scale attention from the pharmaceutical industries due to its diverse biological activities such as lipid-lowering, anti-atherosclerosis, and anticoagulation. This review clarifies the pharmacological effects of fucoidan in the treatment of human cardiovascular and cerebrovascular diseases. Fucoidan exerts a hypolipidemic effect by increasing the reverse transport of cholesterol, inhibiting lipid synthesis, reducing lipid accumulation, and increasing lipid metabolism. Inflammation, anti-oxidation, and so on have a regulatory effect in the process of atherosclerosis endothelial cells, macrophages, smooth muscle cells, and so on; fucoidan can not only prevent thrombosis through anticoagulation and regulate platelet activation, but also promote the dissolution of formed thrombi. Fucoidan has a neuroprotective effect, and also has a positive effect on the prognosis of the cardiovascular and cerebrovascular. The prospects of applying fucoidan in cardio-cerebrovascular diseases are reviewed to provide some theoretical bases and inspirations for its full-scale development and utilization.

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“…High performance liquid chromatography or commonly known as HPLC is an analytical technique used to separate, identify or quantify each component in a mixture. The mixture is separated using the basic principle of column chromatography and then identified and quantified by spectroscopy [17].…”

Section: Identification and Characterization Of The Isolated Terpenes...mentioning

confidence: 99%

Effect of terpenes fraction of Iraqi cicer arietinum in experimentally induced hyperlipidemic mice

Hwerif

Raghif

Kadhim

2022

ijhs

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The aim of this study is to investigate the antihyperlipidimic effect of Terpenes fraction of Iraqi Cicer areitinum in high-fat diet (HFD)-fed mice. Animals were divided into four groups (n =8). The total duration of the study was 56 days split into two intervals. During the first 28-days interval, mice were administered with HFD, whereas during the second 28-days interval they were co-administered HFD plus Terpenes (500mg/kg: p.o.) or the standard drug Atorvastatin (10mg/kg:p.o.). Terpenes treatment to HFD-induced hyperlipidemic mice caused a high significant decrement in the levels of total cholesterol, triglycerides, LDL-C and VLDL-C. Moreover, Terpenes resulted in significant increase in the levels of HDL-C, whereas it caused remarkable decreases in ALT, AST and ALP enzymatic activities also in total serum bilirubin levels among hyperlipidemic mice. Besides that, Terpenes treatment showed significant improvement in levels of tissue MDA and GSH in hyperlipidemic mice. Histopathological examination of hyperlipidemic mice showed a disorganized hepatic tissue, marked and diffused cytoplasmic fatty infiltration which was all ameliorated by Terpenes administration. The results revealed that Terpenes (500mg/kg;p.o.) possess potential ameliorating benefits against hyperlipidemia induced by HFD on lipid profile, liver function enzymes, oxidative stress parameters and hepatic histo-architecture.

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Antihyperlipidemic potential of diosmin in Swiss Albino mice with high-fat diet induced hyperlipidemia

Cited by 9 publications

References 38 publications

Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy

Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy

Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases

Effect of terpenes fraction of Iraqi cicer arietinum in experimentally induced hyperlipidemic mice

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