Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats

Kasiappan, Ravi; Rajasekaran, S.; Subramanian, S.

doi:10.1016/j.fct.2005.04.004

Cited by 191 publications

(127 citation statements)

References 35 publications

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“…It is the major cause of morbidity in developing countries (RAVI; RAJASEKARAN; SUBRAMANIAN, 2005). Nowadays, it is considered the fourth leading cause of death worldwide.…”

Section: Introductionmentioning

confidence: 99%

Effects of different concentrations of passion fruit peel (Passiflora edulis) on the glicemic control in diabetic rat

Salgado¹,

Bombarde²,

Mansi³

et al. 2010

Ciênc. Tecnol. Aliment.

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“…It is the major cause of morbidity in developing countries (RAVI; RAJASEKARAN; SUBRAMANIAN, 2005). Nowadays, it is considered the fourth leading cause of death worldwide.…”

Section: Introductionmentioning

confidence: 99%

Effects of different concentrations of passion fruit peel (Passiflora edulis) on the glicemic control in diabetic rat

Salgado¹,

Bombarde²,

Mansi³

et al. 2010

Ciênc. Tecnol. Aliment.

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“…The hypolipidaemic effect and lowering of cholesterol and triglycerides could be probably attributed to decreasing 3-hydroxyl-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase activity), a key enzyme of cholesterol biosynthesis and/or by reducing the NADPH required for fatty acids and cholesterol biosynthesis (Sharma et al, 2003 andVessal et al, 2003). Also, the clove might stimulate the production of insulin which in turn inhibits lipoprotein lipase activity (Ravi et al, 2005). In general, the present study concluded that administration of clove extract significantly reduced blood sugar and lipid peroxide content in diabetic rats and restored the GSH content and insulin level, which indicate the antioxidant activity and the hypoglycaemic effect of clove and its essential oil.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycaemic Effect of γ-Irradiated Clove Extract on Alloxan-Induced Diabetic Rats

2011

Egypt. J. Rad.Sci.

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IABETES is characterized by hyperglycaemia and elevated production of reactive oxygen species (ROS). Clove is full of natural antioxidants such as polyphenols and essential oils. The aim of the study was to investigate the hypoglycaemic effect of clove extract in diabetic rats.The results with test rats indicated that alloxan administration induced the elevation of glucose level, activity of some liver enzymes, malondialdehyde (MDA), urea and creatinine concentrations as well as the level of some lipid contents.While the level of insulin, total thyroid hormones triiodothyronin (T 3 ) and thyroxine (T 4 ), glutathione content (GSH) in addition to the concentration of high density lipoprotein (HDL-C) were decreased under the effect of alloxan.As a result of treatment of diabetic rats with raw or irradiated clove extract, hyperglycaemia, hepatic, renal and endocrine abnormalities induced by alloxan were improved.Conclusion: clove extract exerts a dietary antidiabetic benefit and affect a partial normalization of the biochemical changes associated with alloxan-induced diabetes mellitus in rats. Furthermore, the study indicated that treatment of cloves with 10 kGy of gamma irradiation had no significant effect on the antidiabetic properties of the extract made from such cloves. This confirms the suitability of irradiation for the improvement of the hygienic quality of cloves.

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“…Studies with the seeds of S. cumini have already demonstrated hypocholesterolemic and hypotriglyceridemic effects (Sharma et al, 2003;Ravi et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, studies with the seeds have shown that they reduce the plasma glucose levels in alloxan diabetic rats and rabbits; and a hypolipidemic effect has also been shown for this part of the plant (Sharma et al, 2003;Ravi et al, 2005). Investigations involving the bark have demonstrated that it causes a significant decrease in blood glucose levels in the glucose tolerance test (Villase˜nor & Lamadrid, 2006).…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and hypolipidemic effect of leaves from Syzygium cumini (L.) Skeels, Myrtaceae. in diabetic rats

Schoenfelder¹,

Warmlin²,

M³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Efeito hipoglicêmico e hipolipidêmico das folhas de Syzygium cumini Lam. em ratos diabeticos". Na região de Criciúma-SC, as folhas de Syzygium cumini (L.) Skeels, Myrtaceae, conhecida popularmente como jambolão, são utilizadas para diminuir níveis de glicose plasmática em pessoas diabéticas. Dentro deste contexto o presente trabalho teve o interesse de avaliar o efeito hipoglicêmico e hipolipidêmico do extrato bruto hidroalcoólico (EBH) das folhas de S. cumini (125, 250 e 500 mg/kg). Para tal os animais foram divididos em três grupos para o efeito hipoglicêmico: ratos normais, ratos normais submetidos a curva de glicose (hiperglicêmicos) e ratos diabéticos induzidos com aloxana. O efeito hipolipidêmico foi avaliado em animais diabéticos induzidos por aloxana. O efeito hipoglicêmico foi comparado com glibenclamida. O tratamento agudo com EBH de S. cumini causou uma diminuição estatisticamente significativa na glicose sanguínea em animais normais que foram submetidos à cura de glicose (250 mg/kg), e sobre os níveis de glicose (125 e 250 mg/kg), triglicerídeo (125 e 500 mg/kg) e colesterol (125 mg/kg) em animais diabéticos. Nenhuma das doses testadas apresentou efeito em animais normais. Dentro deste contexto pode-se sugerir que o EBH das folhas de S. cumini pode ser uma alternativa terapêutica no tratamento alternativo ou complementar na diabete, uma vez que apresentou atividade hipoglicêmica e hipolipidêmica em animais diabéticos.Unitermos: Syzygium cumini, Myrtaceae, diabete, hipoglicêmico, hipolipidêmico, plantas medicinais.ABSTRACT: Ethanolic crude extract (ECE) of leaves from Syzygium cumini (L.) Skeels, Myrtaceae was screened for its hypoglycemic and hypolipidemic activity (125, 250 and 500 mg/kg v.o.). Rats were divided into three groups for the evaluation of the hypoglycemic effect: normal rats, rats with alloxan-induced diabetes and hyperglycemic normal rats. Hypolipidemia was evaluated in rats with alloxan-induced diabetes. The antihyperglycemic activity was compared to treatment with glibenclamide, an oral hypoglycemic agent. The acute treatment with S. cumini ECE caused a significant decrease in the blood glucose in hyperglycemic normal rats (250 mg/kg), and in glucose (125 and 250 mg/kg), triglyceride (125 and 500 mg/kg) and cholesterol (125 mg/kg) levels of diabetic rats, but no effect was observed in the normal treated rats. Syzygium cumini leaves are a good candidate for alternative and/or complementary medicine in the management of diabetes mellitus, since they showed hypoglycemic activity in addition to a hypolipidemic action in diabetic animals.

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Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats

Cited by 191 publications

References 35 publications

Effects of different concentrations of passion fruit peel (Passiflora edulis) on the glicemic control in diabetic rat

Effects of different concentrations of passion fruit peel (Passiflora edulis) on the glicemic control in diabetic rat

Hypoglycaemic Effect of γ-Irradiated Clove Extract on Alloxan-Induced Diabetic Rats

Hypoglycemic and hypolipidemic effect of leaves from Syzygium cumini (L.) Skeels, Myrtaceae. in diabetic rats

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