Antihyperlipidemic Agents Cause a Decrease in von Willebrand Factor Levels in Pediatric Patients with Familial Hyperlipidemia

Yalçın, S. Songül; Güneş, Bülent; Ünal, Şule; Gümrük, Fatma; Coşkun, Turgay

doi:10.1515/jpem.2010.126

Cited by 2 publications

(2 citation statements)

References 18 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6) is in agreement with the known production of these proteins by vascular and hepatic tissues, respectively. Hyperlipidemia and non-alcoholic liver steatosis is associated in some studies with higher production of factors VII and vWF [47-50]. Aldh1a1 −/− mice resist HF-diet induced hyperlipidemia and triglyceride accumulation in the liver seen in WT mice on an obesogenic diet [38].…”

Section: Discussionmentioning

confidence: 99%

Moderate vitamin A supplementation in obese mice regulates tissue factor and cytokine production in a sex-specific manner

Gushchina

Yasmeen

Ziouzenkova

2013

Archives of Biochemistry and Biophysics

View full text Add to dashboard Cite

Vitamin A (vitA) regulates obesity, insulin resistance, inflammation, dyslipidemia, and hemostasis through its metabolites retinaldehyde (Rald) and retinoic acid (RA) produced in endogenous enzymatic reactions. Combination of at least 3 of these conditions leads to development of metabolic syndrome (Msyn) and, consequently, type 2 diabetes and/or cardiovascular disease. Although many foods are fortified with vitA, it remains unknown what conditions of Msyn are influenced by moderate dietary vitA supplementation. A family of aldehyde dehydrogenase 1 (Aldh1) enzymes is a key contributor to obesity via sex- and fat depot-specific production of RA in adipose tissue. Therefore, we studied effects of moderate vitamin A supplementation of an obesogenic high-fat (HF) diet (4IU vitA/g and 20IU vitA/g HF diet) on multiple conditions and mediators of Msyn in wild-type (WT, C57Bl/6) and Aldh1a1−/− mice. We found that mild vitamin A supplementation did not influence obesity, fat distribution, and glucose tolerance in males and females of the same genotype. In contrast, multiplex analysis of bioactive proteins in blood showed moderately increased concentrations (10-15%) of inflammatory IL-18 and MIP-1γ in vitA supplemented vs. control WT males. Marked decrease (28-31%) in concentrations of lymphotactin and tissue factor, a key protein contributing to thrombogenesis during injury, was achieved by vitA supplementation in WT females compared to control WT females. Aldh1a1 deficiency reduced obesity, insulin resistance, suppressed many pro-inflammatory cytokines, and abolished the effects of vitA supplementation seen in WT mice. Our study revealed specific inflammatory and pro-thrombotic proteins in plasma regulated by dietary vitamin A and the critical role of endogenous vitA metabolism in these processes. The sex-specific decrease of plasma tissue factor concentrations by moderate dietary vitA supplementation could potentially reduce related pro-thrombotic states in obese females.

show abstract

Section: Discussionmentioning

confidence: 99%

Moderate vitamin A supplementation in obese mice regulates tissue factor and cytokine production in a sex-specific manner

Gushchina

Yasmeen

Ziouzenkova

2013

Archives of Biochemistry and Biophysics

View full text Add to dashboard Cite

show abstract

“…Estos resultados son preocupantes si tenemos en cuenta que las recomendaciones actuales sugieren no exceder los 200 mg/dl de colesterol total para los adultos. Al respecto, un 25% de la población escolar sobrepasa dichos valores 8 .…”

Section: Perfil Lipídico En La Infancia Situación Actualunclassified

Perfil lipídico y sus características entre la población infantil

Jiménez

2011

Rev Clin Med Fam

View full text Add to dashboard Cite

Aceptado para su publicación el 18 de junio de 2011. RESUMEN En la actualidad se acepta que la aterosclerosis tiene su inicio a edades cada vez más tempranas. para la salud pública, ello debido fundamentalmente a su relación con una mayor incidencia de enfermedad cardiovascular en la etapa adulta. Los valores plasmáticos de colesterol total y colesterol ligado a lipoproteínas de baja densidad son muy elevados en la actual población infantil. Ello parece tener su explicación en una dieta poco saludable, hipercalórica y rica en grasas saturadas, si bien estudios recientes indican la existencia de otros factores implicados, como son la genética y ciertas alteraciones hormonales. El objetivo de este trabajo ha sido Palabras clave. Valores Lipídicos, Niños, Dieta, Genes.

show abstract

Antihyperlipidemic Agents Cause a Decrease in von Willebrand Factor Levels in Pediatric Patients with Familial Hyperlipidemia

Cited by 2 publications

References 18 publications

Moderate vitamin A supplementation in obese mice regulates tissue factor and cytokine production in a sex-specific manner

Moderate vitamin A supplementation in obese mice regulates tissue factor and cytokine production in a sex-specific manner

Perfil lipídico y sus características entre la población infantil

Contact Info

Product

Resources

About