Antihyperlipidemic activity of sesquiterpene lactones and related compounds

Hall, Iris H.; Lee, K.H.; Starnes, C.O.; Muraoka, Osamu; Sumida, Yoichi; Waddell, Thomas G.

doi:10.1002/jps.2600690622

Cited by 54 publications

(38 citation statements)

References 30 publications

(5 reference statements)

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“…40 times less cytotoxicity than 99 [19], suggesting that the a-methylidene-glactone moiety is necessary for the cytotoxicity. This result was in agreement with previous reports [205] [208] [209]. Another observation without any exceptions in the case of terpenoids was that the (E)-isomer ((E)-H) displays almost half the activity compared with its (Z)-isomer ((Z)-H) [67].…”

Section: Otherssupporting

confidence: 94%

Secondary Metabolites of Plants from the Genus Saussurea: Chemistry and Biological Activity

Wang

Dong

et al. 2010

Chemistry & Biodiversity

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The Asteraceae family comprises ca. 1000 genera, mainly distributed in Asia and Europe. Saussurea DC., as the largest subgenus of this family, comprises ca. 400 species worldwide, of which ca. 300 species occur in China. Most plants in China grow wild in the alpine zone of the Qingzang Plateau and adjacent regions at elevations of 4000 m. Plants of the genus Saussurea (Asteraceae) are used in both traditional Chinese folk medicine and Tibet folklore medicine, since they are efficacious in relieving internal heat or fever, harmonizing menstruation, invigorating blood circulation, stopping bleeding, alleviating pain, increasing energy, and curing rheumatic arthritis. A large number of biologically active compounds have been isolated from this genus. This review shows the chemotaxonomy of these compounds (215 compounds) such as sesquiterpenoids (101 compounds), flavonoids (19 compounds), phytosterols (15 compounds), triterpenoids (25 compounds), lignans (32 compounds), phenolics (23 compounds), and chlorophylls (11 compounds). Biological activities (anti-inflammatory, anticancer, antitumor, hepatoprotective, anti-ulcer, cholagogic, immunosuppressive, spasmolytic, antimicrobial, antiparasitic, antifeedant, CNS depressant, antioxidant, etc.) of these compounds, including structure-activity relationships, are also discussed.

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Section: Otherssupporting

confidence: 94%

Secondary Metabolites of Plants from the Genus Saussurea: Chemistry and Biological Activity

Wang

Dong

et al. 2010

Chemistry & Biodiversity

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“…Also, DhL could act as a ''cell stabilizer'' by inhibiting the degranulation of cells containing monoamines (Penissi et al, 1998). An anti-inflammatory effect has previously been observed in other sesquiterpene lactones (Hall et al, 1979). Recently, several Asteraceae (Artemisia ludoviciana subsp.…”

Section: Discussionmentioning

confidence: 88%

“…Sesquiterpene lactones suppressed T-cell delayed hypersensitivity with both methylated bovine albumin and chicken egg albumin. T-lymphocyte production seemed to be depressed with helenalin having the best effects (Hall et al, 1979). It is also possible that DhL may act by the above-mentioned mechanisms, but the effect of DhL on inhibition of neutrophil infiltration and T-cell delayed hypersensitivity has yet to be determined.…”

Section: Discussionmentioning

confidence: 99%

Intrarectal Dehydroleucodine Suppresses Trinitrobenzene Sulfonic Acid–Induced Colitis in Rats, A Model for Inflammatory Bowel Disease

Wendel¹,

María²,

Domínguez³

et al. 2007

Pharmaceutical Biology

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Dehydroleucodine (DhL), isolated from Artemisia douglasiana Besser (Asteraceae), prevents damage in acetic acid-induced colitis in rats. The trinitrobenzene sulfonic acid (TNBS)-induced model of chronic inflammation of the rat colon was used to determine the efficacy of DhL, at dose of 40 mg=kg, administered in enema form. All rats were sacrificed on day 7 and the colon excised, weighed, and rated macroscopically. Sections of colon were processed for light microscopy. Macroscopic scoring showed a decrease (p < 0.001) in the degree of damage in the DhL group compared with the group of rats treated with TNBS. Colon mass decreased (p < 0.05) in the DhL group compared with the TNBS group. Treatment with DhL resulted in a reduction in the incidence of diarrhea. Light-microscopic examination revealed preservation of mucosal architecture in the DhL-treated rats. DhL had an effective healing capacity at both macroscopic and microscopic levels. We conclude that DhL decreases injury and=or promotes healing in this model.

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“…Sesquiterpene lactones were demonstrated to possess anti-inflammatory properties in vivo (Hall et al, 1979), and they inhibit neutrophil migration and chemotaxis in vitro (Hall et al, 1980). The mechanisms by which sesquiterpene lactones inhibit inflammatory processes are not completely understood, but recent data demonstrated that these compounds are potent inhibitors of the proinflammatory transcription factor NF-jB (Hehner et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and Anti-inflammatory Activities and Acute Toxicity ofAchillea nobilis. subsp.neilreichii. Extract in Mice and Rats

Karabay-Yavasoglu¹,

Karamenderes

Baykan

et al. 2007

Pharmaceutical Biology

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The ethanol extract of Achillea nobilis L. subsp. neilreichii (Kerner) Formanék (Asteraceae) flower heads was investigated for its antinociceptive and anti-inflammatory activities and for acute toxicity in mice and rats. While the extract exhibited an antinociceptive effect during the late phase of the formalin test (100, 200, and 400 mg=kg, i.p.) and an anti-inflammatory effect in the paw edema test (100 and 200 mg=kg, i.p.), it did not exert any significant antinociceptive effect in the tail-flick test. Furthermore, administration of 400 mg=kg extract increased the latency to hot-plate test at 60 and 90 min. No significant change was detected in sensory motor performance. The acute LC 50 value of the extract was 4456 mg=kg (i.p.) in mice. The current results demonstrate that an ethanol extract of A. nobilis L. subsp. neilreichii exerts anti-inflammatory activity.

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Antihyperlipidemic activity of sesquiterpene lactones and related compounds

Cited by 54 publications

References 30 publications

Secondary Metabolites of Plants from the Genus Saussurea: Chemistry and Biological Activity

Secondary Metabolites of Plants from the Genus Saussurea: Chemistry and Biological Activity

Intrarectal Dehydroleucodine Suppresses Trinitrobenzene Sulfonic Acid–Induced Colitis in Rats, A Model for Inflammatory Bowel Disease

Antinociceptive and Anti-inflammatory Activities and Acute Toxicity ofAchillea nobilis. subsp.neilreichii. Extract in Mice and Rats

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