Antihyperlipidemic activity of alcoholic leaf extract of Solanum surattense in streptozotocin-diabetic rats

Sridevi, M; Kalaiarasi, Panneerselvam; Pugalendi, Kodukkur Viswanathan

doi:10.1016/s2221-1691(11)60171-8

Cited by 22 publications

(12 citation statements)

References 34 publications

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“…It is traditionally used for treatment of fever, asthma, cough, toothache, sexual diseases and to promote female fertility [7, 12]. Moreover, ample of biological screenings of S. surattense revealed that it had a significant anti-fungal [13], anti-plasmodial [14], anti-hyperlipidemic [15] and anti-diabetic [16] efficacies. In addition, while S. surattense seeds aqueous extract has been shown to deplete the oxidative stress of cauda epididymal spermatozoa [17], its e thanol extract is recently shown to have diuretic activity [18] in albino rats.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of Solanum surattense leaf extract against chemical- induced oxidative and apoptotic injury in rats

Parvez

Al‐Dosari

Arbab

et al. 2019

BMC Complement Altern Med

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Background Of over 35 Saudi plants traditionally used to treat liver disorders, majority still lack scientific validations. We therefore, evaluated the anti-oxidative, anti-apoptotic and hepatoprotective potential of Solanum surattense leaves total ethanol-extract (SSEE). Methods The cytoprotective (4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide/ MTT assay) and anti-apoptotic (caspase-3/7) potential of SSEE (25–200 μg/mL) were assessed in cultured HepG2 cells against dichlorofluorescein (DCFH)-induced toxicity. The hepatoprotective salutation of SSEE (100 and 200 mg/kg.bw/day) in carbon tetrachloride (CCl 4 )-intoxicated rats was evaluated by serum biochemistry and histopathology. The anti-oxidative activity of SSEE (31.25–500 μg/mL) was tested by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging and linoleic acid bleaching assays. Also, SSEE was subjected to qualitative phytochemical analysis, and standardized by validated high-performance liquid chromatography (HPTLC). Results SSEE at doses 50, 100 and 200 μg/mL showed HepG2 cell proliferative and protective potential by about 61.0, 67.2 and 95%, respectively through inhibition of caspase-3/7 against DCFH-toxicity. In CCl 4 -injured rats, SSEE (200 mg/kg) significantly ( P < 0.001) normalized serum transaminases, alkaline phosphatase, bilirubin, cholesterol, triglycerides, and total protein, including tissue malondialdehyde and nonprotein sulfhydryls levels, supported by the liver histopathology. SSEE further showed strong in vitro anti-oxidative and anti-lipid peroxidative activities, evidenced by the presence of alkaloids, flavonoids, tannins, sterols and saponins. Identification of β-sitosterol (3.46 μg/mg) strongly supported the anti-oxidative and hepatoprotective salutation of SSEE. Conclusion Our findings suggest the therapeutic potential of S. surattense against chemical-induced oxidative stress and liver damage. However, isolation of the active principles and elucidation of mechanism of action remain to be addressed.

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Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of Solanum surattense leaf extract against chemical- induced oxidative and apoptotic injury in rats

Parvez

Al‐Dosari

Arbab

et al. 2019

BMC Complement Altern Med

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“…The fruit of Solanum surattense has hypoglycemic potential activity in diabetic rats (62). Sridevi et al, (63) have been studied the effect of S. surattense in diabetic rats brought back the rate of increase in blood glucose and decrease in insulin level to normal. The scientific investigation revealed the hypoglycemic potential in diabetic rats (41).…”

Section: Anti-diabetic Activitymentioning

confidence: 99%

A review on the pharmaceutical activity of Solanum surattense

Kumar¹

2021

GSC Adv. Res. Rev.

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The traditional medicinal plants are believed to be an impotent source of phytochemicals with potential therapeutic effects, and caring for different diseases. The plant Solanum surattense has active phytochemicals like saponins, alkaloid, phenols, solamargine, solasurine, solasonine, gum, ascorbic acid, sterols, torvoside K, torvoside L, khasianine, glycosides, flavonoids, aculeatiside A, solamargine, glycoalkaloid, steroidal compound, steroidal alkaloids, polyphenol (caffeic acid), coumarins (esculentin and aesculin), steroids (carpesterol, campesterol, daucosterol, stigmasterol, cycloortanol, and cholesterol), triterpinins, and sapogenin. This medicinal plant is widespread in pharmaceutics and still presents a large source of active phytochemicals with different activity such as antimicrobial, anti-larvicidal, anthelmintic, antimalarial, antioxidant, antidiabetic, anti-asthmatic, and anti-cancerous. This review of the literature revealed new researches on the phytochemicals of S. surattense that how the active phytochemicals are performed different activities on the molecular level in vital aspects.

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“…Sparrow grass/ Satavari Scientific name: Asparagus racemosus Family: Asparagaceae Part Used: root digitonin and tomatine bind to the cholesterol and increase its precipitation in vitro and inhibit the cholesterol absorption without bile acid absorption in vivo [53] 36 Kantakari Scientific name: Solanum surattense Family: Solanaceae Part Used: leaves Leaves extract decreased in the cholesterogenesis and reduced fatty acid synthesis, and this may be also due to the enhancement of the glucose utilization [54] 37. Tamarind…”

Section: E-and Z-guggulsterone Isomers Of the Guggalmentioning

confidence: 99%

Natural remedies for hyperlipidemia: A review

Dasgupta¹,

Bandyopadhyay²,

Sarkar³

et al. 2021

J Pharmacogn Phytochem

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Hyperlipidemia is a popular disorder and a state of body where there is elevated level of triglyceride above 200mg/dl, LDL above 160mg/dl, Total cholesterol above 200mg/dl and HDL below40mg/dl. Now it can be found on every other person, when LDL increases it travels through our blood vessels and tends to accumulate in the vessels the accumulation is not for lipids only it consists of calcium and fibrous plaque, and this scenario leads to atherosclerosis. Atherosclerosis causes narrowing of blood vessels, leads to lesser blood flow to the heart results in angina pectoris and gradually heart attack. There are many marketed medicines fighting against this, but they have adverse effects like muscle toxicity. Here, are some natural remedies which we come across everyday are fighting these situations which are very easily available in nature, and we can take it in our regular diet.

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Antihyperlipidemic activity of alcoholic leaf extract of Solanum surattense in streptozotocin-diabetic rats

Cited by 22 publications

References 34 publications

Hepatoprotective effect of Solanum surattense leaf extract against chemical- induced oxidative and apoptotic injury in rats

Hepatoprotective effect of Solanum surattense leaf extract against chemical- induced oxidative and apoptotic injury in rats

A review on the pharmaceutical activity of Solanum surattense

Natural remedies for hyperlipidemia: A review

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