Antihyperglycemic Potential ofGrewia asiaticaFruit Extract against Streptozotocin-Induced Hyperglycemia in Rats: Anti-Inflammatory and Antioxidant Mechanisms

Abstract

Diabetes mellitus is regarded as a serious chronic disease that carries a high risk for considerable complications. In folk medicine, the edible Grewia asiatica fruit is used in a number of pathological conditions. This study aimed to investigate the possible curative effect of G. asiatica fruit ethanolic extract against streptozotocin- (STZ-) induced hyperglycemia in rats. Furthermore, mechanism of antihyperglycemic action is investigated. Hyperglycemic rats are either treated with 100 or 200 mg/kg/day G. asiatica fruits extract. Serum glucose, liver glycogen, malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), interleukin- (IL-) 1β, and tumor necrosis factor- (TNF-) α are measured. G. asiatica fruits extract reduces blood glucose and pancreatic MDA levels. It increases liver glycogen and pancreatic GSH contents and SOD enzyme activity. Furthermore, Grewia asiatica fruits extract decreases serum IL-1β and TNF-α. The treatment also protects against STZ-induced pathological changes in the pancreas. The results of this study indicated that G. asiatica fruit extract exerts antihyperglycemic activity against STZ-induced hyperglycemia. The improvement in the pancreatic β-cells and antioxidant and anti-inflammatory effects of G. asiatica fruit extract may explain the antihyperglycemic effect.

Anticancer and anti-inflammatory perspectives of Pakistan’s indigenous berry Grewia asiatica Linn (Phalsa)

“…G. asiatica has been cited as a good source of phenolic acids, flavonoids and a small amount of tannins. However, more promising results have been delivered from the present study compared with earlier studies where G. asiatica methanolic extracts were found to deliver 144 mg GAE/g total phenolics, 4.61 mg QE/g total flavonoids and 4.9 mg/kg anthocyanins [33,34].…”

A 3-year follow-up study of β-cell function in patients with early-onset type 2 diabetes

“…First, chronic hyperglycemia has been shown to inhibit β-cell response, which has been demonstrated both in vitro and in vivo (30). Exposure of β-cells to sustained levels of hyperglycemia may deplete the insulin secretory granules from the β-cell, leaving less insulin available for release in response to further hyperglycemia (31). Lowering of glucose levels allows more complete granulation of β-cells and thus improved acute insulin responses (32).…”

Analysis and Characterization of Anthocyanin from Phalsa (Grewia asiatica)

“…Incontrovertible evidence has been documented that G. asiatica fruit has an antioxidative and antiradical capacity, 14 particularly its peel, mush and seed. In this regard, assessed the antioxidant activity of G. asiatica leaves extract while Rymbai, H et al 8 evaluated its greater antiradical potential up to 95.87% in Swiss albino mice.…”