Antihyperglycemic Effect ofGinkgo bilobaExtract in Streptozotocin-Induced Diabetes in Rats

Abstract

The Ginkgo biloba extract (GBE) has been reported to have a wide range of health benefits in traditional Chinese medicine. The aim of this study was to evaluate the antihyperglycemic effects of GBE on streptozotocin- (STZ-) induced diabetes in rats. Diabetes was induced in male Wistar rats by the administration of STZ (60 mg/kg b.w.) intraperitoneally. GBE (100, 200, and 300 mg/kg b.w.) was administered orally once a day for a period of 30 days. Body weight and blood glucose levels were determined in different experimental days. Serum lipid profile and antioxidant enzymes in hepatic and pancreatic tissue were measured at the end of the experimental period. Significant decreases in body weight and antioxidant ability and increases in blood glucose, lipid profile, and lipid peroxidation were observed in STZ-induced diabetic rats. The administration of GBE and glibenclamide daily for 30 days in STZ-induced diabetic rats reversed the above parameters significantly. GBE possesses antihyperglycemic, antioxidant, and antihyperlipidemia activities in STZ-induced chronic diabetic rats, which promisingly support the use of GBE as a food supplement or an adjunct treatment for diabetics.

Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed

“…Garcinia kola is seen to prevent these changes and thus restore the body weight of the diabetic treated rats. This finding is similar to previous studies (15)(16)(17)(18) involving the use of glibenclamide in the treatment of diabetes. Daye et al, (16) reported that glibenclamide suppressed the decrease in the body weight and while the suppression of weight loss in our study was achieved using Garcinia kola extract.…”

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

“…The body weight in diabetic rats was significantly decreased compared to normal rat, as shown in previous study (Almeida et al, 2012). The diabetic rat group showed a consistent higher blood glucose level as expected (Cheng et al, 2013), while aqueous extract of H. sabdariffa (HSE) was shown to successfully reduce the blood glucose level significantly probably due to polyphenols are well known as hypoglycaemic agents (Ojulari et al, 2014; Rosemary et al, 2014). …”

Olive and ginkgo extracts as potential cataract therapy with differential inhibitory activity on aldose reductase

“…Recently, OLE has been reported for its potential hypoglycemic activity following chronic systemic administration in overweight middle-aged men who are at risk of developing the metabolic syndrome as well as in experimental animals (10,26). Likewise, GLE has been shown to possess anti-hyperglycemic activity in streptozotocin (STZ)-induced diabetic rats (27). These anti-diabetic effects are mediated via preservation of insulin positive β-cells and restoration of the glucose metabolic enzyme activities (28,29).…”