Antihyperglycemic effect of aqueous and ethanolic extracts of Gongronema latifolium leaves on glucose and glycogen metabolism in livers of normal and streptozotocin-induced diabetic rats

Rauwolfia vomitoria and Gongronema latifolium extracts influences cerebellar cortex

“…The use of such plant as Rauwolfia vomitoria and Gongronema latifolium has been on the increase due to their known medicinal values. R. vomitoria and G. latifolium show promises as antioxidants, anti-diabetics and analgesics among others [7][8][9][10][11].…”

“…Its leaf is extensively used, and is reported to contain alkaloids, saponins, tannins, flavonoids and glycosides [28]. GL is reported to have hypoglycemic, antibacterial, antioxidant, anti-inflammatory, anti-ulcer, analgesic, antidiabetic, anti-pyretic and cardio-protective properties [8,[28][29][30][31][32][33][34]. These useful properties endeared the choice for its combination with RV.…”

Effects of <i> Gongronema latifolium </i> on blood lipids, lipoproteins and glucose values in adult Nigerians

“…17 This observed hypoglycemic potency of G. latifolium has been suggested to be mediated through the activation of hexokinase, phosphofructokinase, glucose-6-phosphate dehydrogenase and inhibition of glucokinase in the liver. 18 When these enzymes are activated, glycolysis and glycogenesis proceed faster resulting in lowering of blood glucose.…”

Comparative Proximate Composition and Hypoglycemic Properties of Three Medicinal Plants (Verononia amygdalina, Azadirachta indica and Moringa oleifera).

“…[40,[69][70] The leaves of Gymnema sylvestre (Gumer) [71] and the fruits of T. catappa Linn [50] induced β-cell regeneration in simultaneous with β-cell stimulation and suppression of gluconeogenic enzymes [72] that corroborates the plausible mode of action of V. amygdalina, A. indica and M. oleifera extracts. From another perspective, Ugochukwu and Babady, [73] reported that the long-term hypoglycemic property of Gongronema latifolium extract was mediated by activation of hepatic hexokinase, phosphofructokinase, glucose-6-phosphate dehydrogenase in diabetic rats. In furtherance to these findings, Ngozi et al, [74] posited that the glycemic control mechanism of G. latifolium could be linked to the capability of the extract to increase cellular ratio of reduced glutathione to oxidized glutathione (GSH/GSSG).…”