Antihyperglycemic, antioxidant and hypolipidemic effect of Punica granatum L flower extract in streptozotocin induced diabetic rats

Bhaskar, Anusha; Kumar, Amit

doi:10.1016/s2221-1691(12)60491-2

Cited by 21 publications

(10 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Punica granatum flower extract is reported to possess antihyperglycemic (Bhaskar et al, 2012;Jafri et al, 2000) and renal protective activity (Singh et al, 2011). Therapeutically beneficial chemical constituents similar to that of flower extract have been reported from P. granatum leaves such as ellagitannins, gallic acid, anthocyanins, piperidine alkaloids, flavonoids namely luteolin, apigenin, and quercetin (Garachh et al, 2012;Lansky et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Flavonoid rich fraction ofPunica granatumimproves early diabetic nephropathy by ameliorating proteinuria and disturbed glucose homeostasis in experimental animals

Ankita

Deepti

Nilam

2014

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Different parts of Punica granatum Linn. (Punicaceae) are traditionally used as renal protective agents in the Indian system of medicine. However, there is paucity of information regarding its role in diabetic nephropathy. Objective: The present study investigates the nephroprotective potential of flavonoid-rich fraction of P. granatum leaves in streptozotocin (STZ)-induced early diabetic nephropathy in experimental animals. Materials and methods: Experimental diabetic nephropathy was induced in Wistar rats by single intraperitonial injection of STZ (65 mg/kg) dissolved in ice cold citrophosphate buffer (pH 4.3). After induction rats were divided into five groups (6 normal; 24 diabetic) and administered with glibenclamide (5 mg/kg) and three dose levels of flavonoid-rich fraction of P. granatum leaves (PGFF), i.e. 50, 100, and 200 mg/kg body weight/day for 28 d. Fasting blood glucose, lipid profile, serum albumin, serum total protein, serum creatinine, blood urea nitrogen (BUN) glycosylated hemoglobin, and biomarkers of kidney oxidative stress were assessed at the end of the treatment period. Urine was analyzed for the measurement of total protein, albumin, and creatinine clearance. Kidney sections were subjected to histopathological study. Results: Daily oral administration of variable dose levels of PGFF for 28 d normalized various biochemical, metabolic, and histopathological changes in the diabetic rats. PGFF significantly (p50.01 and p50.05) improved the glycemic status and renal function in diabetic rats as compared with diabetic control rats. Discussion and conclusion: The results of our study thus prove the protective effect of PGFF in early diabetic nephropathy by ameliorating proteinuria and disturbed glucose homeostasis in experimental animals.

show abstract

Section: Introductionmentioning

confidence: 99%

Flavonoid rich fraction ofPunica granatumimproves early diabetic nephropathy by ameliorating proteinuria and disturbed glucose homeostasis in experimental animals

Ankita

Deepti

Nilam

2014

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…It is known that HDL participates in the transport of cholesterol from peripheral tissues to the liver, thus inhibiting the genesis of atherosclerosis. [27] Treatment with CC seed extract (300 mg/ kg) and insulin for 28 days was sufficient to produce a significant decrease in serum TC and TG levels, suggesting that the polyphenolic components of CC have a hypolipidemic effect. The marked elevation in the level of HDL suggests a cardioprotective effect of CC treatment.…”

Section: |Discussionmentioning

confidence: 92%

Modulation of aquaporins expressions and its impact on alleviating diabetic complications in rats: role of Citrullus colocynthis

Ismail¹,

Nassan²,

Alkhedaide³

et al. 2016

Natl J Physiol Pharm Pharmacol

View full text Add to dashboard Cite

Background: Aquaporins (AQPs) belong to a class of small, integral membrane proteins that enable water transfer across the plasma membranes of cells as a reaction to osmotic gradients. There are 13 known types of AQPs in humans (AQP0 to AQP12), which are expressed in various organs such as the kidney, brain, liver, lungs, and salivary glands. In patient with diabetes mellitus, a reduction in salivary secretion is noted in concurrence with low salivary AQP5 levels. The Citrullus colocynthis (CC) extracts were reported to have beneficial effects on glucose homeostasis and body weight maintenance, in either alloxan-or streptozotocin (STZ)-induced diabetic rats through exerting insulinotropic effect. Aims and Objective: To check the changes in AQPs expression and to understand the antidiabetic effect of CC as a medicinal herb in STZ-induced diabetic rats. Materials and Methods: Forty-two male Wistar rats were assigned equally into six groups. The first and second groups were kept as control groups: the first remained without treatment, but the second received CC orally. Diabetes was induced by a single intraperitoneal (i.p) injection of STZ (60 mg/kg b.w.) in the remaining four groups. Three diabetic groups were treated with insulin or CC or both together for 4 weeks. The remaining diabetic group was left untreated as control diabetic group. Blood and organs were taken for biochemical, gene expression, and immunohistochemistry examinations. Result: Diabetic rats displayed increases in blood glucose, lipid profile, liver, and kidney parameters, which were restored significantly to normal with insulin or CC or both. At molecular level, diabetic rats showed significant downregulation in mRNA expressions of antioxidant enzymes, insulin receptor substrate 1 and 2, pyruvate kinase, GLUT-2 in liver and of AQP1, AQP5, AQP7, and AQP8 expressions in kidney, salivary gland, and pancreas, respectively, and normalized significantly by insulin or CC or in combination administrations. Expressions of phosphoenol pyruvate carboxykinase in liver and of AQP2 and AQP3 in kidney were upregulated in diabetic rats and returned to normal completely by insulin alone or CC or their combination. Values were statistically significant at p o 0.05. Immunohistochemical examinations revealed a downregulation of insulin and GLUT-2 in pancreas and upregulation of AQP2 in kidney of diabetic rats, but treatments with CC augmented insulin effect and restored their expression to normal levels. Conclusion: Current results concluded that AQPs could be a promising target for drug development. Moreover,

show abstract

“…Plant extract: Secretagogue to release insulin, induces hypoglycemia (in control rats) (powdered seeds), induced-hypoglycemia (normal rabbits) initiating release of insulin from pancreatic beta cells [53,57] Jamun [58][59][60] Anar/Gulnar Punica granatum (Gulnar/Flower) Flower extracts antioxidant, anti-hyperglycemic effect with reduction in glycosylated hemoglobin levels (STZ-induced DM. in rats) [61] Pomegranate flower has dual PPAR-α/-γ activator properties which is a major regulator of lipid and glucose metabolism and is a natural PPAR α and γ agonist. [62] Inhibition of carbohydrate digestive enzymes (a-amylase and a-glucosidase) and their phenolic content may contribute to the anti-hyperglycemic effects of pomegranate flower and peel support its claim in diabetes in Unani and Chinese Medicine [63] Bel…”

Section: Acacia Arabicamentioning

confidence: 99%

Unani Formulations for Management of Diabetes: An Overview

Hamiduddin¹

2018

IJGP

View full text Add to dashboard Cite

Diabetes is a leading cause of death. In India, total number of diabetic patients is expected to be 79.4 million in 2030. It is a multifactorial disease leading to several complications. Traditional medicines are being looked up once again for its treatment; the WHO also recommended its further investigation. In this review, these drug its pharmacological activity and its formulation in Greco-Arab or Unani Medicine in India is explored. Singledrug used in formulation with reported anti-diabetic and related beneficial property are Gymnema sylvestre, Azadirachta indica, Aloe vera, Momordica charantia, Acacia arabica, Eugenia jambolana, Trigonella foenum graecum, Punica granatum, etc. Phytomedicine used in Unani medicine presents an exciting opportunity for the development of new types of therapeutics for diabetes mellitus with a holistic approach, which includes various photochemical groups such as alkaloids, terpenes, and phenolics. Beside hypoglycemic activity, these drugs also have antioxidants, bitter and other activity related to disturbance in carbohydrate metabolism. They are used in the form of decoctions, infusions, tablets, pills, and powder such as Qurse Dhayabitus, Qurse Tabasheer, Safoof Gilo, Qurse Marwareed, Qurse Gulnar, Dawaul Misk Talkh, Sharbate Afsanteen, Roghane Qusht, and Ma-Usshaeer and common marketed formulation is Dolabi tablets, Qurs Kushta baiza murgh, Qurs Kushta Zamarrud, Qurs Ziabetus, Safoof Ziabtes, Diab-eaze, etc. There is the tremendous scope of Unani single and compound formulations in the comprehensive management of diabetes particularly Type-2 diabetes; it can also be utilized as an adjuvant with the conventional drug due to its diverse and related beneficial pharmacological activity in diabetes.

show abstract

Antihyperglycemic, antioxidant and hypolipidemic effect of Punica granatum L flower extract in streptozotocin induced diabetic rats

Cited by 21 publications

References 18 publications

Flavonoid rich fraction ofPunica granatumimproves early diabetic nephropathy by ameliorating proteinuria and disturbed glucose homeostasis in experimental animals

Flavonoid rich fraction ofPunica granatumimproves early diabetic nephropathy by ameliorating proteinuria and disturbed glucose homeostasis in experimental animals

Modulation of aquaporins expressions and its impact on alleviating diabetic complications in rats: role of Citrullus colocynthis

Unani Formulations for Management of Diabetes: An Overview

Contact Info

Product

Resources

About