Antihyperglycemic, antioxidant activities of tucumã oil ( Astrocaryum vulgare ) in alloxan-induced diabetic mice, and identification of fatty acid profile by gas chromatograph: New natural source to treat hyperglycemia

Baldissera, Matheus D.; Souza, Carine F.; Grando, Thirssa H.; Cossetin, Luciana F.; Sagrillo, Michele Rorato; Nascimento, Kátia; Silva, Aleksandro S. Da; Machado, Alencar Kolinski; Cruz, Ivana Beatrice Mânica da; Stefani, Lenita M.; Klein, Bruna; Wagner, Róger; Monteiro, Sílvia González

doi:10.1016/j.cbi.2017.04.001

Cited by 26 publications

(15 citation statements)

References 45 publications

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“…A. vulgare (tucumã oil) was extracted from pulp fruit gathered in the Amazon forest (Amazonia, Brazil) using the cold pressing method and purchased from Amazon Oil Industry. Tucumã oil was characterized by gas chromatography, and the main compound identified was the oleic/elaidic fatty acid (368.70 mg/g of oil), as recently published by Baldissera et al ().…”

Section: Methodsmentioning

confidence: 69%

“…Experimental diabetes was induced in overnight fasted (12 hr fasted) mice by a single intraperitoneal injection of alloxan monohydrate (75 mg/kg) diluted into sterile cold saline solution (0.9%), as previously reported by Baldissera et al (). Age‐matched control mice received an equivalent amount of saline solution.…”

Section: Methodsmentioning

confidence: 99%

“…Glucose levels were measured with a portable glucometer (Advantage, Boehringer Mannheim, MO). Only animals with fasting glycemia above 250 mg/dL were considered diabetic and used in this study (Baldissera et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…The potent antioxidant activity of tucumã is well reported in the literature (Bonnafous, Viton, & Maraval, ), as well as its anti‐inflammatory properties (Bony et al, ). Based on these findings, tucumã has become an attractive therapeutic agent to treat a variety of pathologies, including diabetes (Baldissera et al, ). The mechanisms underlying the benefits of tucumã oil are not totally elucidated, but have been related to its antioxidant activity which protects tissues, such as liver, against a variety of damages that could be caused by oxidative stress (Bonnafous et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…The mechanisms underlying the benefits of tucumã oil are not totally elucidated, but have been related to its antioxidant activity which protects tissues, such as liver, against a variety of damages that could be caused by oxidative stress (Bonnafous et al, ). Furthermore, the anti‐diabetic effect of tucumã oil has been verified by ameliorating the antioxidant status in pancreatic tissues (Baldissera et al, ). However, its hepatoprotective effects, if any, in diabetic‐induced mice are not known.…”

Section: Introductionmentioning

confidence: 99%

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Tucumã oil (Astrocaryum vulgare) ameliorates hepatic antioxidant defense system in alloxan-induced diabetic mice

et al. 2017

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The aim of this study was to investigate whether treatment with Astrocaryum vulgare oil (tucumã oil), a hypoglycemic natural compound, was able to reduce hepatic oxidative stress of diabetic mice. An increase in lipid peroxidation and decrease in catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) activities, as well as glutathione reductase (GSH) levels were observed in diabetic/water group. Treatment with tucumã oil prevented lipid peroxidation and inhibition of CAT and SOD activities in diabetic mice. The tucumã oil treatment may provide effective protection against lipid oxidative damage in the liver tissue of diabetic mice, since it improved the enzymatic antioxidant defense system. Therefore, the tucumã oil can be an important coadjutant in the treatment of diabetes, contributing to the prevention and reduction of oxidative damage. Practical applicationsRecently, it was demonstrated that tucumã oil exerts potent antihyperglycemic effect in alloxaninduced diabetic mice. The oil improved the pancreatic oxidant/antioxidant status, playing an essential role in the hypoglycemic effect. The results showed that tucumã oil can reduce oxidative stress in liver tissue, and consequently, prevent the hepatic alterations caused by high glucose levels. K E Y W O R D Santioxidant, catalase, glucose, lipid peroxidation, liver

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Section: Methodsmentioning

confidence: 69%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tucumã oil (Astrocaryum vulgare) ameliorates hepatic antioxidant defense system in alloxan-induced diabetic mice

et al. 2017

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Current Scenario and Recent Advancements from Tucumã Pulp Oil and Kernel Fat Processing

Ferreira

Mota

Mariano

et al. 2022

Euro J Lipid Sci & Tech

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According to the Food and Agricultural Policy Research Institute, the demand for edible oils and fats is growing. Tucumã is a native Amazonian fruit with high lipids content in the pulp and kernel. The pulp oil has a high content of unsaturated fatty acids and carotenoids, mainly 𝜷-carotene, a pro-vitamin A. Kernel fat has high oxidative stability as it is rich in saturated fatty acids, with a predominance of lauric acid. Tucumã pulp oil and kernel fat can formulate functional fats due to their physicochemical, nutritional, and sensory properties. This paper aims to provide an overview of intellectual property and academic production about tucumã oil and fat. The increase in scientific production from 2001 to 2020 indicates that the research institutes have expanded interest in tucumã fruit. However, intellectual property using tucumã oil and fat for industrial applications is still modest. Using the selected keyword combinations, nineteen and ten papers related to pulp oil and kernel fat are met, respectively. The United States leads the patents publications related to tucumã fruit, oil, and fat (45%). Most patents are directed to the cosmetic and pharmaceutical sectors (59%), demonstrating the necessity for studies focused on applications in the food industry. Practical Applications: Tucumã pulp oil and kernel fat can be used to formulate functional fats due to their physicochemical, nutritional, and sensory properties. The tucumã pulp oil has a high content of unsaturated fatty acids and carotenoids, mainly 𝜷-carotene, a pro-vitamin A. The tucumã kernel fat presents high oxidative stability as it is rich in saturated fatty acids, with a predominance of lauric acid. Most patents are directed to the cosmetic and pharmaceutical sectors, which demonstrate the need for studies focused on the food industry. The small number of patents favors promising partnerships between companies and scientific institutions for the transfer of academic knowledge of new technologies applied in the food industry.

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Bioactive Compounds of Tucuma (Astrocaryum aculeatum G. Mey.)

Cruz¹,

Barbisan²,

Ribeiro³

2019

Reference Series in Phytochemistry

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Antihyperglycemic, antioxidant activities of tucumã oil ( Astrocaryum vulgare ) in alloxan-induced diabetic mice, and identification of fatty acid profile by gas chromatograph: New natural source to treat hyperglycemia

Cited by 26 publications

References 45 publications

Tucumã oil (Astrocaryum vulgare) ameliorates hepatic antioxidant defense system in alloxan-induced diabetic mice

Tucumã oil (Astrocaryum vulgare) ameliorates hepatic antioxidant defense system in alloxan-induced diabetic mice

Current Scenario and Recent Advancements from Tucumã Pulp Oil and Kernel Fat Processing

Bioactive Compounds of Tucuma (Astrocaryum aculeatum G. Mey.)

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