Antihyperglycemic and Hypolipidemic Potential of Kepok Banana Peel in Diabetic Rats

Indriawati, Ratna; Atiyah, FU

doi:10.1088/1755-1315/985/1/012040

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Banana stems have a high glycemic index, are rich in fiber and antioxidants, and have a hypoglycemic effect. 17 This study was conducted to determine the effectiveness of the Kepok banana stem (Musa paradisiaca Var. Balbisiana colla) against diabetes mellitus therapy by observing malondialdehyde (MDA) levels in diabetes mellitus rats.…”

Section: Discussionmentioning

confidence: 99%

The use of Kepok Banana Stem (Musa paradisiaca) in diabetes rats does not reduce Malondialdehyde (MDA) levels

2022

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Introduction: The prevalence of diabetes mellitus (DM) is still high and is expected to continue to increase. An increase follows this increase in the number of side events, so innovation is needed in DM therapy. DM induces oxidative stress so antioxidants can be an alternative therapy for DM. One source of antioxidants whose use is still limited is the banana plant, especially the banana stem. This study aimed to determine the effectiveness of kepok banana stem extract (Musa paradisiaca Var. Balbisiana colla) on MDA levels in diabetic rats. Methodology/Approach: The study used a post-test-only control group design on 24 male rats (Rattus novergicus) Sprague Dawley strain with a bodyweight of 150-250 grams and ± eight weeks old. Rats were divided into four groups, namely the metformin treatment for positive control, distilled water for the negative control, and stem banana extract dose of 200 mg/kg BW and 250 mg/kg BW as treatment group of mice induced diabetes using STZ-NA and given treatment according to the group for 14 days. MDA level measurement using the TBARS method on rat liver. Data were analyzed using the One Way ANOVA comparison test. Results: MDA levels in the positive control group, negative control, treatment 1 (200 mg), and treatment 2 (250 mg) were 0.9790 + 0.52 mg/dl, 0.7533 + 0.58 mg/dl, 1.2510 + 0.52 mg/dl, 1.5175 + 0.53 mg /dl. There was no statistically significant difference in MDA levels between groups (p=0.182), but there was a decrease in blood glucose levels in the group treatment. The highest decrease in blood glucose levels was in the dose treatment group, 250 mg/kg BW. Conclusion:The treatment of kepok banana stem extract (Musa paradisiaca Var. Balbisinia colla) for 14 days at 200mg/kg BW and 250mg/kg BW increased malondialdehyde (MDA) levels, although not statistically significant.

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Section: Discussionmentioning

confidence: 99%

The use of Kepok Banana Stem (Musa paradisiaca) in diabetes rats does not reduce Malondialdehyde (MDA) levels

2022

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Fruit waste: a current perspective for the sustainable production of pharmacological, nutraceutical, and bioactive resources

Sha,

Modak,

Sarkar

et al. 2023

Front. Microbiol.

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Fruits are crucial components of a balanced diet and a good source of natural antioxidants, that have proven efficacy in various chronic illnesses. Various kinds of waste generated from fruit industries are considered a global concern. By utilizing this fruit waste, the international goal of “zero waste” can be achieved by sustainable utilization of these waste materials as a rich source of secondary metabolites. Moreover, to overcome this waste burden, research have focused on recovering the bioactive compounds from fruit industries and obtaining a new strategy to combat certain chronic diseases. The separation of high-value substances from fruit waste, including phytochemicals, dietary fibers, and polysaccharides which can then be used as functional ingredients for long-term health benefits. Several novel extraction technologies like ultrasound-assisted extraction (UAE), pressurized liquid extraction (PLE), and supercritical fluid extraction (SFE) could provide an alternative approach for successful extraction of the valuable bioactives from the fruit waste for their utilization as nutraceuticals, therapeutics, and value-added products. Most of these waste-derived secondary metabolites comprise polyphenols, which have been reported to have anti-inflammatory, insulin resistance-treating, cardiovascular disease-maintaining, probiotics-enhancing, or even anti-microbial and anti-viral capabilities. This review summarizes the current knowledge of fruit waste by-products in pharmacological, biological, and probiotic applications and highlights several methods for identifying efficacious bioactive compounds from fruit wastes.

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Antioxidants Activity Assessment and Utilization of Banana Peels to Attenuate the Diabetes Mellitus

Zahid

Tufail

Imran³

et al. 2022

PBMJ

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Diabetes is the primary metabolic disorder listed among the top 10 death-causing diseases. The complete cure of diabetes is impossible, but the prevention and maintenance of glucose levels can reduce the diabetes severity. Objectives: To utilize the banana peel extracts to evaluate their antioxidant attributes and capability to attenuate diabetes. Methods: The antioxidant properties were assessed by measuring the DPPH, total phenolic contents (TPC), and total flavonoid contents (TFC) in ethanol, methanol, and acetone solutions. Moreover, the renal functional tests (Serum creatinine, serum urea, and BUN) and liver function tests (ALT, ASP, Serum Albumin, and total proteins) were also conducted during the 21 days experimental study in diabetes-induced (via Streptozotocin: 350 mg/kg) male Albino Wister rats. Results: The results indicated that the DPPH, TPC, and TFC contents were higher in methanol solution, i.e., 74.20±0.98%, 54.78±0.69mg GAE/g, and 39.48±0.37mg GAE/g respectively. Moreover, the results indicated that the unripe, ripe, and overripe significantly reduced liver and renal function parameters in diabetic rats. Conclusions: Banana peels have prominent potential to prevent diabetes-linked variables due to their higher antioxidant activity.

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Antihyperglycemic and Hypolipidemic Potential of Kepok Banana Peel in Diabetic Rats

Cited by 3 publications

References 23 publications

The use of Kepok Banana Stem (Musa paradisiaca) in diabetes rats does not reduce Malondialdehyde (MDA) levels

The use of Kepok Banana Stem (Musa paradisiaca) in diabetes rats does not reduce Malondialdehyde (MDA) levels

Fruit waste: a current perspective for the sustainable production of pharmacological, nutraceutical, and bioactive resources

Antioxidants Activity Assessment and Utilization of Banana Peels to Attenuate the Diabetes Mellitus

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