Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats

Singh, Jyotsna; Kakkar, Poonam

doi:10.1016/j.jep.2009.02.038

Cited by 160 publications

(89 citation statements)

References 30 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The decreased activity of endogenous antioxidant enzymes (SOD and CAT) also causes initiation and propagation of LPO. An increased oxidative stress leads to the rise in LPO level and it is associated with an elevation in BGL (Singh & Kakkar 2009;Kharbanda et al 2014). Decreased MDA level in EFSD (200, 400 and 800 mg/kg b.wt) treated groups show the reversal of LPO level that supports the antioxidant activity of EFSD in STZ À NA-induced diabetic rats.…”

Section: Discussionsupporting

confidence: 59%

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Gopinath

Muthusamy

Chellappan

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant activities of ethanol extract of S. densiflorum (EFSD) fruits in streptozotocin (STZ) and nicotinamide (NA)-induced diabetic rats. Materials and methods Acute oral toxicity and oral glucose tolerance were assessed in normal rats. The antidiabetic, antihyperlipidaemic and antioxidant activities were investigated in STZ À NAinduced diabetic rats. Diabetic rats were orally administered with glibenclamide (10 mg/kg b.wt), EFSD (200, 400 and 800 mg/kg b.wt) for 28 d. Further, changes in the blood glucose level (BGL), biochemical parameters, antioxidants were observed and histology of pancreas was performed.Results No toxicity and lethality were observed. Results of the following parameters are represented by treated versus disease control (STZ + NA) groups. BGL (161.33 ± 22.8 versus 476.17 ± 56.58 mg/dl), glycosylated haemoglobin (5.285 ± 0.19 versus 8.05 ± 0.55%), urea (40.32 ± 1.96 versus 75.37 ± 2.91 mg/dl), uric acid (1.2 ± 0.07 versus 2.16 ± 0.05 mg/dl), total cholesterol (89.3 ± 5.14 versus 139.7 ± 5.95 mg/dl) and triglycerides (79.65 ± 2.52 versus 108.9 ± 3.61 mg/dl) were significantly decreased, whereas haemoglobin (11.75 ± 0.73 versus 7.95 ± 0.42 g/dl), high-density lipoprotein cholesterol (14.2 ± 1.11 versus 6.97 ± 0.84 mg/dl), total protein (45%) and liver glycogen (87%) were significantly increased in EFSD-treated diabetic group. Significant changes were observed in the enzymatic and non-enzymatic antioxidants in EFSDtreated groups (p50.001). Histopathological examination showed the regeneration of b-cells in Islets of Langerhans. Conclusion This study confirms the antidiabetic, antihyperlipidaemic and antioxidant activities of S. densiflorum fruits. ARTICLE HISTORY

show abstract

Section: Discussionsupporting

confidence: 59%

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Gopinath

Muthusamy

Chellappan

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…1), one of the main constituents of Coptidis rhizoma and Cortex phellodendri, is an isoquinoline alkaloid with multiple pharmacological activities. BBR has exhibited hypoglycemic, hypolipidemic, anti-oxidation, antitumor and anti-aldose reductase effect, which presents wide clinical values and perspectives in treating diabetes and its complications [13][14][15][16][17][18]. Our previous studies demonstrated that BBR could efficiently ameliorate hyperglycaemia in streptozotocin-induced diabetic rats [19,20].…”

Section: Blood Glucose Liver Glycogen and Glucokinase Activitymentioning

confidence: 99%

Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway

Xie

Lan

et al. 2011

Endocr J

View full text Add to dashboard Cite

“…Previous studies reported its use as an immunomodulatory as well as an anti-inflammatory agent (Gupta et al, 2008). The root extract of the plant, containing berberine (1), palmatine (2) and berbamine (3), exhibited antihyperglycemic and antioxidant activities (Singh & Kakkar, 2009). Chemical structures of the major bioactive alkaloids of B. aristata roots are depicted in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Antiplasmodial activity of aqueous extract ofBerberis aristataroots againstPlasmodium berghei-infected BALB/c mice

Chandel

Bagai

Semwal

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: The rising problem of resistance to present antimalarial drugs stresses the need to look for newer antiplasmodial components with effective modes of action. The roots of Berberis aristata DC. (Berberidaceae) are used in the traditional medicine for malaria in various parts of India. Objective: The objective of this study was to evaluate antiplasmodial activity of B. aristata roots extract for the validation of its traditional medicinal use. Material and methods: Aqueous root extract of Berberis aristata (AREBA) was screened for its in vitro as well as in vivo antiplasmodial activity against lethal rodent malaria parasite Plasmodium berghei NK65. In vitro activity was evaluated against schizont maturation of P. berghei using various concentrations ranging from 1 to 100 mg/mL. For in vivo studies, AREBA at the doses of 150, 250, 350, and 650 mg/kg/d was administered to P. berghei infected BALB/c mice orally for 4 consecutive days (D0-D3). Results: AREBA showed in vitro antiplasmodial activity with an IC 50 value of 40 mg/mL. In vivo studies demonstrated a variable dose-dependent chemosuppression with higher efficacy at lower doses. At a dose of 350 mg/kg/d, the suppressive and preventive activities were found to be 67.1% and 53.9%, respectively, followed by enhancing mean survival period up to 12.8 d for the curative assay versus 7.5 d for the untreated mice. Discussion and conclusion: These results provide relevant scientific evidences for the traditional medicinal use of this plant as malaria remedy and further advocates the isolation and characterization of active antiplasmodial principle from this plant.

show abstract

Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats

Cited by 160 publications

References 30 publications

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway

Antiplasmodial activity of aqueous extract ofBerberis aristataroots againstPlasmodium berghei-infected BALB/c mice

Contact Info

Product

Resources

About