Antihyperglycemic and Antihyperlipidemic Effects of Methanolic Extract of Holarrhena antidysenterica Bark in Alloxan Induced Diabetes Mellitus in Rats

Bandawane, D. D.; Bibave, K.H.; Jaydeokar, A.V.; Patil, UK; Hivrale, M.G.

doi:10.5567/pharmacologia.2013.95.106

Cited by 11 publications

(9 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our finding of antihyperglycemic activity of methanolic extract of H. pubescens bark is supported and are similar to findings documented by Bandawane et al, [20] and Bibave et al, [19]. Bandawane et al, documented that methanolic extract of H. pubescens bark (200, 400 mg/kg) significantly (p<0.01) reduced the increase in blood glucose levels at 60, 90, and 120 min in glucose loaded rats when compared with diabetic control rats [20].…”

Section: Discussionsupporting

confidence: 93%

“…Bandawane et al, documented that methanolic extract of H. pubescens bark (200, 400 mg/kg) significantly (p<0.01) reduced the increase in blood glucose levels at 60, 90, and 120 min in glucose loaded rats when compared with diabetic control rats [20]. Similar findings of antihyperglycemic effect were documented by Bibave et al, with aqueous and methanolic extract of H. pubescens bark on normal rats.…”

Section: Discussionsupporting

confidence: 62%

See 1 more Smart Citation

Evaluation of Antioxidative and Antidiabetic Activity of Bark of Holarrhena Pubescens Wall

Bhusal

Jamarkattel

Shrestha

et al. 2014

JCDR

View full text Add to dashboard Cite

Objective: The objectives of the study are to screen out various phytochemicals and to evaluate the antioxidant and antidiabetic potential of the stem bark of Holarrhena pubescens Wall (Holarrhena antidysenterica). Materials and Methods:The antioxidant activity was determined by the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity where ascorbic acid was taken as positive control. The antioxidant property was later exploited and the methanolic extract of plant was tested for antihyperglycemic activity in glucose overloaded hyperglycemic mice. The extract was tested for its hypoglycemic activity at two-dose levels, 250 and 500 mg/kg respectively where Glipizide 5 mg/kg was taken as standard reference drug. All results are presented as mean ± SD (Standard Deviation). Significant differences between experimental groups were determined by Student's t-test. Results:The methanolic and water extract showed strong antioxidant activity with inhibition of more than 90% DPPH free radicals at the concentration of 100µg/mL. The hypoglycemic activity of methanolic extract on glucose tolerance test were significant (p <0.05) for the effects of 500 mg/kg after 120 min of treatment and (p <0.01) for 250 mg/kg of extract after half hour of treatment compared to control.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 62%

Evaluation of Antioxidative and Antidiabetic Activity of Bark of Holarrhena Pubescens Wall

Bhusal

Jamarkattel

Shrestha

et al. 2014

JCDR

View full text Add to dashboard Cite

show abstract

“…In a similar study on diabetic rats, decreased levels of serum cholesterol, uric acid, aspartate transaminase, triglycerides, creatinine and blood glucose were observed. Another study also demonstrated that a hydro-methanolic seed extract of H. pubescens causes inhibition of α glucosidase (a gut exoenzyme that releases glucose from di- and oligo-saccharides and aryl glucosides in the diet, thereby increasing absorption of glucose from the intestine) [ 110 ]. An ethanol extract of its seeds also prevented weight loss in diabetic rats and corrected biochemical parameters.…”

Section: Pharmacologymentioning

confidence: 99%

Metabolic Diversity and Therapeutic Potential of Holarrhena pubescens: An Important Ethnomedicinal Plant

et al. 2020

View full text Add to dashboard Cite

Holarrhena pubescens is an important medicinal plant of the Apocynaceae family that is widely distributed over the Indian subcontinent. The plant is extensively used in Ayurveda and other traditional medicinal systems without obvious adverse effects. Beside notable progress in the biological and phytochemical evaluation of this plant over the past few years, comprehensive reviews of H. pubescens are limited in scope. It has economic importance due to the extensive use of seeds as an antidiabetic. Furthermore, the plant is extensively reported in traditional uses among the natives of Asia and Africa, while scientifical validation for various ailments has not been studied either in vitro or in vivo. This review aims to summarize information on the pharmacology, traditional uses, active constituents, safety and toxicity of H. pubescens. Chemical analysis of H. pubescens extracts revealed the presence of several bioactive compounds, such as conessine, isoconnessine, conessimine, conimine, conessidine, conkurchicine, holarrhimine, conarrhimine, mokluangin A-D and antidysentericine. Overall, this review covers the ethnopharmacology, phytochemical composition, and pharmacological potential of H. pubescens, with a critical discussion of its toxicity, biological activities (in vitro and in vivo), the mechanism of action, as well as suggestions for further basic and clinical research.

show abstract

“…Presence of flavonoides, phenolic compounds present in bark were found to be responsible for antioxidant and antidiabetic activity 34 . Bark extract showed improvement in liver glycogen and glucose uptake 35 .…”

Section: Kutaja [Holarrhena Antidysenterica (Linn)wall]mentioning

confidence: 99%

Anti diabetic potential of some selected traditionally used Medicinal Plants in Western Ghats of India w.s.r to Prameha

Rashmi¹

2017

IJAHM

View full text Add to dashboard Cite

Traditional remedies are gaining worldwide acceptability. In the developing country like India safe, efficient and economic indigenous remedies are gaining popularity among the urban and rural areas. Diabetes is one of the major lifestyle disease which remains without a promising management solution in conventional medicine. In Ayurveda, this disease can be largely equated to a disease process called Prameha. The Western Ghats consists of unusual flora of Sahyadri hills representing dense and diversified vegetation. The people here are largely dependent on the available natural resources for food and medicine at primary level in treatment of diabetes. Not much work has been done so far for exploration of anti diabetic activity of these medicinal plants in correlation with its mode of action in perspective of Ayurveda texts and modern literature collectively. So the paper will highlight the anti diabetic potential of some selected medicinal plants used here for diabetic treatment through available Ayurveda literature and recent researches done so far.

show abstract

Antihyperglycemic and Antihyperlipidemic Effects of Methanolic Extract of Holarrhena antidysenterica Bark in Alloxan Induced Diabetes Mellitus in Rats

Cited by 11 publications

References 11 publications

Evaluation of Antioxidative and Antidiabetic Activity of Bark of Holarrhena Pubescens Wall

Evaluation of Antioxidative and Antidiabetic Activity of Bark of Holarrhena Pubescens Wall

Metabolic Diversity and Therapeutic Potential of Holarrhena pubescens: An Important Ethnomedicinal Plant

Anti diabetic potential of some selected traditionally used Medicinal Plants in Western Ghats of India w.s.r to Prameha

Contact Info

Product

Resources

About