Antihyperglycemic and antihyperlipidemic activities of wild musk melon (Cucumis melo var. agrestis) in streptozotocin-nicotinamide induced diabetic rats

Gopalasatheeskumar, K; Ariharasivakumar, Ganesan; Kalaichelvan, V. K.; Sengottuvel, T; Devan, V. Sanish; Srividhya, V.

doi:10.1016/j.chmed.2020.02.005

Cited by 11 publications

(6 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the 21st day, the blood glucose levels were significantly declined in Metformin (65 mg/kg, p.o) and HABEA (200 and 400 mg/kg, p.o) treated rats. The increased in serum glucose levels due to diabetes induced by STZ [18]. The decreased of blood glucose level maybe the reason of anti-hyperglycemic effect of HABEA.…”

Section: Resultsmentioning

confidence: 97%

Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

Abarnadevika¹,

Kavitha²,

Gopalasatheeskumar³

2022

jrp

View full text Add to dashboard Cite

Worldwide diabetes and diabetic neuropathy is the highly prevalent healthcare problem. Herbal based therapy is an alternative and safe management of this problem. Adenanthera pavonina is an important medicinal plant having many of the medicinal values. This research aimed to evaluate the antihyperglycemic and neuroprotective activity of bark of Adenanthera pavonina. Hydro alcohol (50% methanol) was used as the solvent for extraction. Streptozotocin (55 mg/kg, i.p) induced diabetic rats were used for the evaluation of antihyperglycemic and neuroprotective activity. Diabetic rats were treated with hydro alcoholic bark extract of Adenanthera pavonina (HABEA) for 21 days. After treatment period blood glucose levels, SGOT, SGPT, Glutamate and Lipid peroxidase levels were decreased significantly in HABEA (200 and 400 mg/kg, p.o) treated rats. However, body weight, Serotonin, GABA, total protein and reduced glutathione levels were increased. And also behavioral parameter such as pain behavior (Hot Plate Method and Tail Immersion Method) and locomotor behavior (actophotometer) were significantly improved in HABEA (200 and 400 mg/kg, p.o) treated rats. These are the findings confirms that, the HABEA has significant antihyperglycemic and neuroprotective activity. Alkaloids, glycosides, flavonoids, saponin, phenolics and phytosterol present in the bark of Adenanthera pavonina may be the reason for its antihyperglycemic and neuroprotective activity. Further, this research will useful for the isolation of active principles from HABEA and determining its molecular mechanisms.

show abstract

Section: Resultsmentioning

confidence: 97%

Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

Abarnadevika¹,

Kavitha²,

Gopalasatheeskumar³

2022

jrp

View full text Add to dashboard Cite

show abstract

“…These results support the hypothesis that hyperglycemia in diabetes is linked with oxidative stress, the formation of ROS, or the shortage of antioxidant defensive systems [ 23 ]. Furthermore, the considerable reduction in enzymatic and nonenzymatic antioxidants in diabetic rats could be related to an increase in ROS production, as well as the presence of H 2 O 2 and other hydrogen radicals [ 4 , 21 , 24 , 25 ]. Because glutathione is an important nonenzymatic antioxidant involved in maintaining cellular integrity, its depletion signals the advancement of cellular damage caused by free radicals.…”

Section: Discussionmentioning

confidence: 99%

“…Also, the elevation in serum total bilirubin may arise from reduced liver uptake, conjugation, or increased bilirubin generation from hemolysis. Protein is vulnerable to free radical damage, and its reduction could be caused by a change in protein metabolism [ 24 ]. Furthermore, diabetic rats showed vascular congestion, mononuclear cellular infiltration, and distorted cellular structure, indicating liver injury [ 21 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Actinidia deliciosa against Streptozotocin-Induced Oxidative Stress, Apoptosis, and Inflammations in Rats

El‐Demerdash

Talaat

El‐Sayed

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The present research intended to assess the possible protective and hypoglycemic effect of Actinidia deliciosa fruit aqueous extract (ADAE) in diabetic rats. The scavenging antioxidant capabilities of ADAE were evaluated using GC-MS analysis. In addition, rats were divided into four groups: control, ADAE, streptozotocin-induced DM (STZ), and STZ-treated rats + ADAE in an in vivo investigation. GC-MS analysis of ADAE was shown to include major components with high total phenolic contents and high DPPH scavenging activity. In diabetic rats, significant elevation in blood glucose level, lipid peroxidation, bilirubin, and lactate dehydrogenase activity as well as a change in lipid profile was observed, while insulin, body and liver weights, enzymatic and nonenzymatic antioxidants, liver function biomarkers, and protein content were significantly decreased. Furthermore, changes in the expression of the peroxisome proliferator-activated receptor (PPAR-γ), apoptotic, and inflammation-related genes were found. In addition, histological differences in rat liver tissue architecture were discovered, corroborating the biochemical modifications. However, consuming ADAE alone reduced lipid peroxidation and improved antioxidant status. Furthermore, diabetic rats given ADAE showed significant reductions in oxidative stress indicators and biochemical parameters, as well as improved tissue structure, when compared to the diabetic rats’ group. Also, ADAE supplementation protects diabetic rats’ hepatic tissue by upregulating PPAR-γ and downregulating apoptotic and inflammatory-related gene expression. In conclusion, A. deliciosa has beneficial protective effects so, it might be used as a complementary therapy in diabetes mellitus.

show abstract

“…Other parameters include cellular oxidation/reduction imbalance and depression in enzymatic and nonenzymatic antioxidants, which are so important in the defense against free radicals generated in diabetes and are used as indicators of oxidative stress. The significant decrease in enzymatic and nonenzymatic antioxidants in diabetic rats might be because of the noted excess generation of ROS by STZ [ 17 , 23 , 24 ]. Glutathione plays a crucial key role in cellular defense versus xenobiotic toxicity because of its thiol group besides its action as a substrate for GPx and GST antioxidant enzymes [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Actinidia deliciosa Mitigates Oxidative Stress and Changes in Pancreatic α-, β-, and δ-Cells and Immunohistochemical and Histological Architecture in Diabetic Rats

El‐Demerdash

Talaat

Ghanem

2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The present study evaluated the antioxidant capacity and antidiabetic effect of Actinidia deliciosa in diabetic rats. Rats were grouped as follows: control, Actinidia deliciosa aqueous extract (ADAE, 1 g/kg, daily and orally), streptozotocin (STZ, 50 mg/kg BW, single intraperitoneal dose), and STZ plus ADAE, respectively. Twenty-eight components were detected by GC-MS analysis with high phenolic contents and high DPPH scavenging activity. In vivo results revealed that rats treated with STZ showed a highly significant elevation in blood glucose and a decrease in insulin hormone levels. Thiobarbituric acid-reactive substances and hydrogen peroxide levels were elevated, while bodyweight, enzymatic, and nonenzymatic antioxidants were significantly decreased. Furthermore, histopathological and immunohistochemical insulin expression, besides ultrastructure microscopic variations (β-cells, α-cells, and δ-cells), were seen in pancreas sections supporting the obtained biochemical changes. Otherwise, rats supplemented with ADAE alone showed an improved antioxidant status and declined lipid peroxidation. Moreover, diabetic rats augmented with ADAE showed significant modulation in oxidative stress markers and different pancreatic tissue investigations compared to diabetic ones. Conclusively, ADAE has a potent antioxidant and hypoglycemic influence that may be utilized as a health-promoting complementary therapy in diabetes mellitus.

show abstract

Antihyperglycemic and antihyperlipidemic activities of wild musk melon (Cucumis melo var. agrestis) in streptozotocin-nicotinamide induced diabetic rats

Cited by 11 publications

References 43 publications

Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

Hepatoprotective Effect of Actinidia deliciosa against Streptozotocin-Induced Oxidative Stress, Apoptosis, and Inflammations in Rats

Actinidia deliciosa Mitigates Oxidative Stress and Changes in Pancreatic α-, β-, and δ-Cells and Immunohistochemical and Histological Architecture in Diabetic Rats

Contact Info

Product

Resources

About