Antihyperglycemic Activity of Banana (Musa nana Lour.) Peel and Its Active Ingredients in Alloxan-Induced Diabetic Mice

Abstract

Abstract. Previous studies have found that banana flowers, leaves, pseudostems, roots, infructescence stalks, and peels (M. paradisiacal (Linn.)) have antihyperglycemic effect. The banana peel (Musa nana Lour.) might have the antihyperglycemic activity, its antihyperglycemic activity and active ingredients remain to be elucidated. In this paper, fresh banana peel was sequential extraction using solvents with decreasing polarity. Then, the ethyl acetate and petroleum ether extracts (EBP and PBP) were chosen to evaluate the antihyperglycemic activity in alloxan-induced diabetic mice. And the antihyperglycemic activity guided fractionation of compounds. The EBP displayed potent antihyperglycemic activity. lupenone and -sitosterol were separated from EBP. Animal experiments results indicated that lupenone could effective reduce blood glucose of diabetic mice. The banana peel and its ingredient lupenone showed promising antihyperglycemic activity. The banana peel could be utilized as a natural source of antihyperglycemic food, health care or drug and lupenone has potential to develop as an antihyperglycemic drug.

Antihyperglycemic Effects and Mode of Actions of Musa paradisiaca Leaf and Fruit Peel Hydroethanolic Extracts in Nicotinamide/Streptozotocin‐Induced Diabetic Rats

“…Oral treatment of diabetic rats, in the current study, with hydroethanolic extracts of M. paradisiaca leaves and fruit peels significantly ameliorated serum glucose level. e observed decrease in the elevated glucose levels is in accordance with studies of Hongmei et al [46] who reported that the banana peel and its ingredient lupenone showed promising antihyperglycemic activity.…”

Major triterpenes, cycloeucalenone and 31‐norcyclolaudenone as inhibitors against both α‐glucosidase and α‐amylase in banana peel

“…More interestingly, based on the comparison of IC 50 values, lupenone has a marginally stronger (less than two times) α-glucosidase inhibitory activity than lupeol, while CE-one showed a significantly stronger inhibitory activity (more than 10 times) than CE-ol. It has been reported that lupenone in banana peel is a candidate possessing potent antidiabetic activity in alloxan-induced diabetic mice (Wu et al, 2015). However, our bioassay-guided fractionation did not identify lupenone in banana peel extract as an inhibitor of α-glucosidase and α-amylase.…”

Maximising recovery of phenolic compounds and antioxidant properties from banana peel using microwave assisted extraction and water

“…The peel has been utilised in traditional medicine for the treatment of a range of ailments including burns, anaemia, diarrhoea, ulcers, inflammation, and excessive menstruation (Kumar et al 2012). Recent studies have reported various pharmacological properties of banana peel, such as inhibition against wide range of bacteria and fungi, reducing blood sugar, cholesterol and also inhibiting the development of some cancer cells (Pereira and Maraschin 2015;Sirajudin et al 2014;Wu et al 2015). In addition, banana peel exhibits strong antioxidant capacity (Singh et al 2016).…”