Antihyperglycaemic, Antihyperlipidaemic and Antihypertensive Effect of a Polyherbal Formulation in Alloxan-Induced Diabetic Rats

Abstract

Polyherbal formulation (POL-4) is popularly used by traditional practitioners to treat diabetes in district Badin, Sindh, Pakistan. This study validates the folk claim of POL-4 in diabetes and associated dysfunctions (hyperlipidaemia, endothelial dysfunction, hypertension) using OGTT and alloxan-challenged diabetic assays. Administration of POL-4 extract (300 mg/kg bw) markedly (p < 0.01) lowered blood glucose levels compared to only glucose loaded (2 g/kg bw) rats. In alloxan (135 mg/kg bw) fed rats, chronic (21 days) administration of POL-4 powder (3% and 6% w/w in diet) significantly (p < 0.001) prevented the rise in systolic blood pressure, heart rate, serum blood glucose and lipid parameters, while improved serum high density lipoprotein-cholesterol and endothelium-dependent aortic acetylcholine-mediated relaxation. POL-4 administration showed no signs of toxicity or lethality in mice at 1-5 g/kg bw doses. These findings attest antihyperglycaemic, antihyperlipidaemic, endothelium modulatory and antihypertensive effects of POL-4, thus providing evidence to the folk use of POL-4 in diabetes and related complications. Rezumat În districtul Badin, Sindh, Pakistan, pentru tratamentul diabetului, este utilizată tradițional o formulare ce conține părți aeriene provenite de la mai multe plante (POL-4). Acest studiu validează folosirea POL-4 în diabet și disfuncții asociate (hiperlipidemie, disfuncție endotelială, hipertensiune), pe un model de diabet zaharat indus cu aloxan. Administrarea extractului POL-4 (300 mg/kgc) a scăzut semnificativ (p < 0,01) nivelul glicemiei față de lotul control tratat cu glucoză (2 g/kgc). La șobolanii tratați cu aloxan (135 mg/kgc), administrarea cronică (21 zile) a POL-4 (3% și 6% m/m în dietă) a prevenit creșterea tensiunii arteriale sistolice, a ritmului cardiac, modificarea parametrilor serici glicemici și lipidici. POL-4 la dozele de 1-5 g/kgc nu a prezentat semne de toxicitate la șoareci.

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