Antihyperglycaemic and aldose reductase inhibitory potential of Acacia catechu hard wood and Tectona grandis leaves

Bhatia, Vikram; Srivastava, Swayam Prakash; Srivastava, Rohit; Mishra, Akansha; Narender, Tadigoppula; Maurya, Rakesh; Srivastava, Arvind K.

doi:10.1007/s00044-010-9473-4

Cited by 12 publications

(9 citation statements)

References 22 publications

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“…The antihyperglycemic activity of an A. catechu ethanolic bark extract has also been demonstrated in alloxaninduced diabetic rats (Jarald et al, 2009). Bhatia et al (2011) have also shown that an ethanol extract of A. catechu hardwood exhibits antihyperglycemic activity in streptozotocin-induced diabetic rats at a dose of 250 mg/kg. Furthermore, the extract showed marked inhibition of aldose reductase enzyme activity in the eye lens of normal rats.…”

Section: Animal Studiesmentioning

confidence: 91%

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Antioxidant, Anti‐inflammatory, and Chemoprotective Properties of Acacia catechu Heartwood Extracts

Stohs

Bagchi

2015

Phytotherapy Research

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Aqueous extracts of Acacia catechu heartwood are rich source of catechin and epicatechin (gallic acid derivatives), with smaller amounts of flavonoids. Extracts have also been prepared with ethyl acetate, ethanol, and methanol, and the properties of these extracts have been studied and are reviewed. Potent antioxidant activity has been well established in both in vitro and in vivo studies. This antioxidant activity is believed to be responsible for the anti-inflammatory, tissue protectant, antineoplastic, and analgesic activities that have been demonstrated and clearly established in animal and cell culture systems. Furthermore, antihyperglycemic, antidiarrheal, antinociceptive, and antipyretic activities have been demonstrated in animal studies. No adverse effects have been observed in animal or human studies or in cell culture systems. In spite of the fact that Acacia products have been used for many years and the general safety of catechins and epicatechins is well documented, few human studies have ever been conducted on the efficacy or safety of A. catechu heartwood extracts. Several studies have shown that a two-ingredient combination product containing A. catechu extract exhibited no adverse effects when administered daily for up to 12 weeks while exhibiting significant anti-inflammatory activity in subjects with osteoarthritis of the knee. There is a need for additional human clinical studies with regard to efficacy and safety.

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Section: Animal Studiesmentioning

confidence: 91%

“…Bhatia et al () have also shown that an ethanol extract of A. catechu hardwood exhibits antihyperglycemic activity in streptozotocin‐induced diabetic rats at a dose of 250 mg/kg. Furthermore, the extract showed marked inhibition of aldose reductase enzyme activity in the eye lens of normal rats.…”

Section: Animal Studiesmentioning

confidence: 96%

Antioxidant, Anti‐inflammatory, and Chemoprotective Properties of Acacia catechu Heartwood Extracts

Stohs

Bagchi

2015

Phytotherapy Research

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“…Future extension of these studies is the driving force behind the search for phytochemical and synthetic compounds such as flavonoids, chalcones, polyhydroquinolines, propiophenone derivatives, deoxyandrographolides, and thiazolidin-4-one derivatives. All of these have shown protective effects in mouse models of diabetes mellitus [285][286][287][288][289][290][291][292][293][294][295][296][297] and can be further tested and potentially utilized in the treatment of diverse forms of cancer cell progression and metastasis.…”

Section: Perspective and Future Directionsmentioning

confidence: 99%

Cancer Biology and Prevention in Diabetes

Srivastava

Goodwin

2020

Cells

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The available evidence suggests a complex relationship between diabetes and cancer. Epidemiological data suggest a positive correlation, however, in certain types of cancer, a more complex picture emerges, such as in some site-specific cancers being specific to type I diabetes but not to type II diabetes. Reports share common and differential mechanisms which affect the relationship between diabetes and cancer. We discuss the use of antidiabetic drugs in a wide range of cancer therapy and cancer therapeutics in the development of hyperglycemia, especially antineoplastic drugs which often induce hyperglycemia by targeting insulin/IGF-1 signaling. Similarly, dipeptidyl peptidase 4 (DPP-4), a well-known target in type II diabetes mellitus, has differential effects on cancer types. Past studies suggest a protective role of DPP-4 inhibitors, but recent studies show that DPP-4 inhibition induces cancer metastasis. Moreover, molecular pathological mechanisms of cancer in diabetes are currently largely unclear. The cancer-causing mechanisms in diabetes have been shown to be complex, including excessive ROS-formation, destruction of essential biomolecules, chronic inflammation, and impaired healing phenomena, collectively leading to carcinogenesis in diabetic conditions. Diabetes-associated epithelial-to-mesenchymal transition (EMT) and endothelial-to-mesenchymal transition (EndMT) contribute to cancer-associated fibroblast (CAF) formation in tumors, allowing the epithelium and endothelium to enable tumor cell extravasation. In this review, we discuss the risk of cancer associated with anti-diabetic therapies, including DPP-4 inhibitors and SGLT2 inhibitors, and the role of catechol-o-methyltransferase (COMT), AMPK, and cell-specific glucocorticoid receptors in cancer biology. We explore possible mechanistic links between diabetes and cancer biology and discuss new therapeutic approaches.

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“…Bhatia et al 55 reported that oral administration of ethanolic extract of A. catechu hard wood at 250 mg/kg elicits significant antihyperglycemic…”

Section: Pharmacological Activities Of Some Anti-diabetic Plantsmentioning

confidence: 99%

Review on Plants for Management of Diabetes in India: An Ethno- Botanical and Pharmacological Perspective

Dixit¹,

Tiwari²

2020

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The diagnosis of early diabetes includes Glycosylated Haemoglobin (HbA1C), Glucose Tolerance Test (GTT), Fasting Plasma Glucose (FPG), Postprandial Plasma Glucose (PPG) test 16 . GTT helps to diagnose gestational diabetes, pre-diabetes, insulin resistance or reactive hypoglycemia. FPG & PPG level reflect the state of recent glycemia, whereas HbA1c level reflects chronic glycaemia. As per American Diabetes Association (ADA), HbA1c should be less than 7% ABSTRACT Background: Diabetes mellitus is a prevalent chronic disease, which is recognized as a common threat to health in the last decade, especially in Asia. It is a lifestyle disease which may cause a number of complications in the body of humans like cardiac failure and dysfunctioning of urinary tract. Materials and Methods: The data is obtained from various search tools and electronic databases like, scientific literature, Google scholar, Google, Pubmed, Web of science and Scopus. Results: Major therapy for diabetes is insulin, oralantidiabetic drugs, and herbal treatment. However, insulin and oral anti-diabetic drugs come with a number of side effects and cannot be afforded by people with below poverty line. The herbal medicines have performed a satisfactory clinical practice for the management of diabetes mellitus. Moreover, pharmacological & phytochemical screening of medicinal plants has also witnessed the hypoglycaemic effects of these plants in treating diabetes mellitus. Majority of the modern drugs like metformin, atropine, digitalis, etc. are also originated from plants. Conclusion: The current paper presents a review of medicinal plants used for diabetes management in India. The therapeutic potential, ethnobotanical use, and their pharmacological evaluations are highlighted for harnessing the anti-diabetic potential of these plants by the Indian healthcare system.

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Antihyperglycaemic and aldose reductase inhibitory potential of Acacia catechu hard wood and Tectona grandis leaves

Cited by 12 publications

References 22 publications

Antioxidant, Anti‐inflammatory, and Chemoprotective Properties of Acacia catechu Heartwood Extracts

Antioxidant, Anti‐inflammatory, and Chemoprotective Properties of Acacia catechu Heartwood Extracts

Cancer Biology and Prevention in Diabetes

Review on Plants for Management of Diabetes in India: An Ethno- Botanical and Pharmacological Perspective

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