Antihypercholesterolemic and Antioxidant Effects of  Blumea balsamifera L. Leaf Extracts to Maintain Luteinizing Hormone Secretion in Rats Induced by High-Cholesterol Diets

Widhiantara, I Gede; Permatasari, Anak Agung Ayu Putri; Rosiana, I Wayan; Wiradana, Putu Angga; Widiastini, Luh Putu; Jawi, I Made

doi:10.18585/inabj.v13i4.1694

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…The blood was collected in a microtube and centrifuged at 4000 rpm for 10 min at room temperature; the plasma was separated and then put in a microtube of 1 mL and stored in a cooler at -70°C in the dark. The MDA serum was measured using the thiobarbituric acid reactive test method (TBARS) (Sun and Zigman, 1978) and SOD level based on with SOD Assay Kit (Catalog No: ESOD-100, Bioassay System) (Widhiantara et al, 2021).…”

Section: Mda and Sod Level Analysismentioning

confidence: 99%

“…The increase in ROS production can degrade polyunsaturated fatty acids (PUFA) and form malondialdehyde (MDA) (Ayala et al, 2014;Kurutas, 2016). The MDA level increases in Wistar rats under hypercholesterolemic conditions (Aryanugraha et al, 2012;Valko et al, 2007;Wahjuni, 2014;Widhiantara et al, 2021). MDA is the final product of the lipid peroxidation process and can cause free compounds or bonds to tissues (Aryanugraha et al, 2012;Michalski et al, 2008;Yui et al, 2021;Yulianti et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Lissachatina fulica chitosan on the antioxidant and lipid profile of hypercholesterolemic male Wistar rats

Umarudin¹,

Widyarti²,

Warsito³

et al. 2022

J Pharm Pharmacogn Res

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Context: The increase in reactive oxygen species production in hypercholesterolemia can degrade polyunsaturated fatty acids and form malondialdehyde (MDA). There is a need for a natural alternative treatment, such as Lissachatina fulica chitosan. Aims: To analyze the potential of Lissachatina fulica chitosan in increasing the superoxide dismutase (SOD) level, reducing lipid profile, and MDA level of male Wistar rats with hypercholesterolemia model. Methods: The male Wistar rats were divided into six groups (n = 4): P0 (normal control); P1-P5 fed a high-fat diet for four weeks. P1 were treated with fed with a high-fat diet; P2 were treated with ezetimibe of 0.18 mg/200 g BW; P3, P4, and P5 Groups; fed with a high-fat diet and Lissachatina fulica chitosan of 100 mg, 200 mg, and 300 mg/200g BW, respectively. The lipid profile was conducted in rat blood samples by using the CHOP-PAP method, the MDA analysis using the TBARS test, and SOD assay analysis using a kit. Results: The results reveal that the treatment Lissachatina fulica chitosan (300 mg/200 g BW) was significantly effective (p<0.05) to decrease in total cholesterol level (96.7 ± 1.9 mg/dL), triglyceride (75.6 ± 1.6 mg/dL), LDL (29.8 ± 2.5 mg/dL), and MDA (1.2 ± 0.1 nmol/mL) as well as a significant increase (p<0.05) in HDL level (75.0 ± 1.7 mg/dL) and SOD (74.6 ± 2.1 unit/mL). Conclusions: Lissachatina fulica chitosan can reduce total cholesterol, triglyceride, LDL, and MDA, and increase HDL and SOD levels.

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Section: Mda and Sod Level Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Lissachatina fulica chitosan on the antioxidant and lipid profile of hypercholesterolemic male Wistar rats

Umarudin¹,

Widyarti²,

Warsito³

et al. 2022

J Pharm Pharmacogn Res

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“…Estrogen helps to relax blood arteries, lower the risk of atherosclerosis and cardiovascular disease in postmenopausal women (Iorga et al, 2017). Testosterone influences muscular growth and adiposity, as well as emotional and cognitive behavior in adult males (Widhiantara et al, 2021). The issue of alcoholism in pubertal humans is largely understudied.…”

Section: Pre-clinical Evidence Of Reproductive Disorders In Humanmentioning

confidence: 99%

“…Heavy drinking generally causes an increase in oxidative stress, chronic inflammation, and intestinal dysbiosis (Louevt and Mathurin, 2015;Widhiantara et al, 2021). Alcohol metabolism, on the other hand, produces a considerable number of reactive oxygen species (ROS) (Mackus et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The Detrimental Effects of Alcohol Consumption on Infertility of Humans and Laboratory Animals: A Review

Nyandra¹,

Widhiantara²,

Wiradana³

2022

WVJ

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In recent decades, the decline in human fertility has become a major concern. However, unhealthy lifestyle practices, such as the use of addictive substances that contribute to infertility persist in society. Therefore, the current study reviewed the literature addressing the effects of alcohol consumption patterns on male and female fertility. Although alcohol intake is socially accepted, its detrimental influence on male and female fertility rates has been regularly observed in recent years. The findings have revealed that abstinence from chronic alcohol intake did not recover the testes from the negative effects of alcohol. Heavy drinking, defined as 8 or more glasses per week for a woman or 15 or more drinks per week for a man might impair female reproductive function. In conclusion, the implementation of an in vivo evidence strategy ranging from animal studies to preclinical ones has indicated that alcohol intake may be related to negative effects on reproductive parameters in both males and females. The present review deserves to be highlighted since it is significant for those who lead an unhealthy lifestyle, such as those who use alcohol.

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“…The antimicrobial capabilities of this herbal plant are attributed to its capacity to create many secondary metabolites with rather complicated structures that have antibacterial and antioxidant characteristics (Chassagne et al, 2021). Oxidative stress, which is defined by the appearance of an imbalance between the development of reactive species and antioxidant defence activity, may intensify in the presence of numerous degenerative disorders and infectious diseases that are caused mostly by microbes (Widhiantara et al, 2021). Antioxidants derived from Cyperus rotundus plant extracts, for examples, have a synergistic impact on ampicillin-resistant S aureus via the disintegration of peptidoglycan and cytoplasmic membranes (Angiolella et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

An overview of the role of Zingiber officinale as an antimicrobial resistance (AMR) solution and a source of antioxidants

et al. 2023

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In this review, we describe the known mechanisms of antimicrobial resistance which was increasing in this era, due to the misuse of antimicrobial agents such as antibiotics, or genetic and phenotypic mechanisms. In this review, the concerns, especially addressed by designated researchers in their study and WHO in their observations and reports, regarding the types or strains of bacteria with antimicrobial resistances were described. In addition, the predicted mechanisms that promote the development and occurrence of antimicrobial resistances, such as bacterial biofilm formation, horizontal gene transfer, genetic mutations, free DNA which contains antimicrobial resistance genes, plasmids transfer through transformation or conjugation from bacterial cell to cell were well described. In addition, we also tried to describe the use of Z. officinale. The antimicrobial capabilities of this herbal plant are attributed to its capacity to create many secondary metabolites with rather complicated structures that have antibacterial and antioxidant characteristics. Z. officinale had been used for many kinds of diseases treatment traditionally. And along the way, the advance techniques of research in chemistry and biology fields had found out the composition and bioactive compound. In this review, the common online databases such as PubMed, Semantic Scholar, Crossref, Medline, Scopus, and Web of Science (WoS) were utilized to conduct literature searches. According to recent progress of antimicrobial cases observed, the efforts to strengthen the surveillance, general health systems, tightened the antimicrobial medicine distribution rules, and education for public are indeed needed.

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Antihypercholesterolemic and Antioxidant Effects of Blumea balsamifera L. Leaf Extracts to Maintain Luteinizing Hormone Secretion in Rats Induced by High-Cholesterol Diets

Cited by 8 publications

References 21 publications

Effect of Lissachatina fulica chitosan on the antioxidant and lipid profile of hypercholesterolemic male Wistar rats

Effect of Lissachatina fulica chitosan on the antioxidant and lipid profile of hypercholesterolemic male Wistar rats

The Detrimental Effects of Alcohol Consumption on Infertility of Humans and Laboratory Animals: A Review

An overview of the role of Zingiber officinale as an antimicrobial resistance (AMR) solution and a source of antioxidants

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