AntiHIV, antibacterial and antifungal activities of some novel 1,4-disubstituted-1,2,4-triazolo[4,3-a] quinazolin-5(4h)-ones

Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies

“…Thus, anthranilic acid was treated with benzoyl chloride in the presence of pyridine to undergo cyclization forming 2-phenyl-4H-benzo [d] [1,3]oxazin-4-one (1), which on condensation with hydrazine hydrate yielded 3-amino-2-phenylquinazolin-4(3H)-one (2). The syntheses of the compounds 1 and 2 have been reported by earlier authors [15].…”

“…Different quinazoline derivatives have been reported for their antibacterial, antifungal, anti-HIV [2,3], anthelmintic [4], CNS depressant [5] and antitubercular [6] activities. Antitumor activities are also reported for 2,3-dihydro-2-aryl-4-quinazolinones [7,8].…”

Synthesis and Characterization of a New Cationic Surfactant Derived from 5-Chloro-1H-indole-2,3-dione In Aqueous Systems

“…The compound has an indole ring structure common to many pharmaceutical products. Its derivatives have exhibited activities such as antibacterial [4], antiinflammatory [5], analgesic [6], anti-viral [7], antifungal [8], anti-tubercular [9], anti-depressant [10] and anticorrosive [11]. The presence of several reaction centers in isatin and its derivatives makes them capable of participating in a large number of reactions [12].The keto group at position 2 and in particular at position 3 can be added to the C-O bond and condensation reactions [13].Through the primary amine group, compounds of the 5-Chloroisatin series are able to penetrate N-alkylation and thereafterquaternization by trimethylamine as an example in the case of the synthesis of the novel surfactants ofindole [14].Generally, the structure of a surfactant is said to be amphiphilic, it is defined by the joint presence of a hydrophilic part and a hydrophobic part, depending on the nature of the hydrophilic part, cationic, anionic or zwitterionic surfactants may be found or nonionic surfactants [15][16][17][18].…”

Synthesis and characterization of quinazoline derivatives: search for hybrid molecule as diuretic and antihypertensive agents

“…Interestingly, all the above-mentionerd compounds possess similar or closely related to quinazoline moiety. Quinazoline derivatives, which belong to the N-containing heterocyclic compounds, have universal concerns due to their wide and distinct biological activities such as diuretic [5][6][7] , antihypertensive 8 , antihistaminic 9,10 analgesic and anti-inflammatory 11,12 anticancer 13 and anti-HIV 14 activities. On the other hand, sulphonamide exhibits acidity in the molecule; these acidic protons enable the formation of the corresponding water-soluble sodium salt and also prevent the carbonic acid from acquiring deprotonated state due to the Zn(II) ion within the enzyme active site which causes diuresis 15,16 .…”