Antihistaminic drug olopatadine downmodulates CCL17/TARC production by keratinocytes and Langerhans cells

Effects of Bepotastine and Fexofenadine on Histamine-Induced Flare, Wheal and Itch

“…Histamine is released from skin mast cells to produce flare and wheal with pruritus by acting on blood vessels and sensory nerves [1,2] and to modulate inflammatory conditions by acting on keratinocytes and other cells [3,4,5,6,7,8,9]. Oral antihistamines are the first-line treatment for urticaria, and their efficacy, speed and duration of action, as well as side effects, such as sleepiness and sedation, depend upon the propensity of each drug [1,2].…”

Antihistaminic drug olopatadine downmodulates T cell chemotaxis toward CCL17 in patients with atopic dermatitis

“…4 Furthermore, OLP downmodulates CCL17/TARC production by LCs as well as keratinocytes (KCs), as OLP at a concentration of 10 À6 or 10 À5 mol/L suppresses the IFN-g/TNF-aaugmented production of CCL17 from HaCaT cells and the mRNA expression of CCL17 and CCL22 in mature bone marrow DCs, a mimicry of pure LCs. 5 More recently, OLP was reported to decrease tissue IL-31 and thymic stromal lymphopoietin levels in an atopic dermatitis (AD) mouse model. 6,7 An in vivo study also showed decreased serum levels of CCL17 and CCL22 in AD patients after treatment with OLP.…”

Assessment of antihistamines in the treatment of skin allergies

“…( Table 3). Interestingly, it has been reported that antihistamines have favorable pharmacological properties on these aspects in vitro [2, [29][30][31][32][33][34][39][40][41][42][43][44][45][46]. Keratinocytes are considered an immunocompetent cell type for the production of cytokines or other biological substances.…”