Antihistaminic Agents Containing a Thiophene Nucleus

Kyrides, L. P.; Meyer, F.; Zienty, Ferdinand B.; Harvey, Jeremy N.; Bannister, Loren W.

doi:10.1021/ja01158a026

Cited by 13 publications

(3 citation statements)

References 1 publication

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 it can be seen that 3DEA1P and 1-(2HE)PRLD have similar vapour pressures and are less volatile than 3DMA1P, while the vapour pressure of 3DMA1P is only slightly lower than that of DEEA reported by Hartono et al [23]. Compared to the literature, the measured temperature of T = 433.7 K at 99.8 kPa for 3DMA1P was close to the boiling temperature of T = (436-437) K at atmospheric pressure reported by Kyrides et al [54] and Kaluszyner and Galun [43], while the values reported by Belabbaci et al [33] was lower than reported in this work. Belabbaci et al [33] reported values in the range of 0.007-2.3 kPa at temperatures between 283.15 K and 373.10 K. Furthermore, it is reasonable that the vapour pressure of 3DMA1P is higher than that of 3DEA1P.…”

Section: Vapour Pressure Of Pure Aminessupporting

confidence: 75%

Vapour-liquid equilibrium study of tertiary amines, single and in blend with 3-(methylamino)propylamine, for post-combustion CO2 capture

Bernhardsen

Trollebø

Perinu

et al. 2019

The Journal of Chemical Thermodynamics

View full text Add to dashboard Cite

This work studies the potential of using the tertiary amines 3-dimethylamino-1-propanol (3DMA1P), 3-diethylamino-1-propanol (3DEA1P) and 1-(2hydroxyethyl)pyrrolidine (1-(2HE)PRLD) as an alternative to 2-(diethylamino)ethanol (DEEA) in the blend with 3-(methylamino)propylamine (MAPA). Vapour pressure of the three tertiary amines and vapour-liquid equilibrium (VLE) of the binary mixtures 3DMA1P/H2O, 3DEA1P/H2O and 1-(2HE)PRLD/H2O at T = (353, 363 and 373) K were measured in a modified Swietoslawski ebulliometer. The vapour pressure of the pure amines was fitted to the Antoine equation , and the P-T-x-y data were fitted to NRTL equations. VLE of the CO2 loaded blended amines were measured in the temperature range of T = 313 to 393 K, and speciation data of equilibrated samples at different CO2 loadings were obtained by NMR spectroscopy. The study showed that the tertiary amines 3DMA1P, 3DEA1P and 1-(2HE)PRLD in the binary amine/ H2O system were less volatile than DEEA in aqueous solution. The CO2 loaded blended amines showed comparable VLE behaviour, as well as speciation, and obtained a cyclic capacity higher than that of 30 wt% MEA but similar to most of the blended amines studied in the literature. The overall results indicated that the tertiary amines studied in this work can be used as an alternative to DEEA.

show abstract

Section: Vapour Pressure Of Pure Aminessupporting

confidence: 75%

Vapour-liquid equilibrium study of tertiary amines, single and in blend with 3-(methylamino)propylamine, for post-combustion CO2 capture

Bernhardsen

Trollebø

Perinu

et al. 2019

The Journal of Chemical Thermodynamics

View full text Add to dashboard Cite

show abstract

“…7 The melting point of 254-256°for the resulting f>-bromobenzoic acid agrees with the reported value. 8 5-Amino-2-bromobenzotrifluoride.6-Although this compound was formed in the experiment described above, larger amounts were obtained when two moles of m-aminobenzotrifluoride was treated with one mole of bromine. The properties of this substance are as follows: b.p.…”

Section: Methodsmentioning

confidence: 97%

“…Generally, under these conditions, the compounds either are only isomerized or else form resins. 8 In the other cases where dimerization in solution did occur and the structures of the products were investigated (methyl benzalpyruvate,4 benzalacetophenone5 and benzal-^-methyl-acetophenone5) the dimers were also found to be of the truxinic type. On the other hand, the photodimer obtained from an acetic acid solution of 2cinnamylidene-2-phenylacetonitrile6 was a truxillic type compound.…”

Section: Mallinckrodtmentioning

confidence: 98%

Notes

1953

J. Am. Chem. Soc.

View full text Add to dashboard Cite

NOTES 3013After separating and drying the crude product, it was dissolved in benzene-60' naphtha solution and decolorized twice with Norite. and the solution evauorated to dnmess an equivalent amount of roll sulfur was carried out using the above procedure giving 0.3 g. of XVII identical with that obtained from XV. in vacuo. The residue was recrystallized from absolute Anal. alcohol-acetone solution to give 0.2 g. of XVII, m.p. 115.2-11.5 80 for C22~ls02: C, a . 0 7 ; H, 5.73. Found: c, 84.24; H, 6.02. _--.-. b. From XI1.-Dehydrogenation of 0.7 g. of XI1 with MISSOULA, MONTANA Synthesis of Phenanthrenes. VI. 5-Hydroxy-8-(5) The experimental verification of this prediction is currently in progress. (6) J. W. Cornforth and R. Robinson, J . Ckem. Soc.. 1855 (1949). 204" (capillary). The analytical sample prepared by furthe: recrystallization from benzene melted at 200.1-200.7 (hot stage). Anal. Calcd. for C~~H Z O O~: C, 77.55; H , 8.68. Found: C, 77.45; H, 8.70. The ultraviolet spectral curve of I1 in ethanol had two maxima, one at 295 m p (log E 3.55), the other at ca. 225 mp could not be determhed accurately with our instrument.An attempt to purify I1 by dissolving in aqueous alkali led to the formation of a brown tar from which a yellow solid could be isolated. An oxidation of I1 (0.93 g.) according to the procedure of Smith and Irwins yielded 0.51 g. (55%) of crude quitlone, m.p. 53-58'.Sublimation produced golden yellow crystals which melted a t 60-62". This quinone was extremely sensitive to air oxidation and darkened rapidly on standin . The ultraviolet spectral curve had maxima at 250 mp bog e 3.85) and 295 mp (log E 3.45) 5 ,&Diacetoxy4a-methyl-1,2,3,4,4a ,9,10,10a-octahyd~ophenanthrene.-A mixture of I1 (0.6 g.), acetic anhydride (2.7 g.) and pyridine ( 5 ml.) was allowed to stand a t room temperature for 40 hours. The reaction mixture was poured into ice-water containing hydrochloric acid (5 nil.) and the product extracted with ether. Evaporation of the ether left a crystalline product (0.5 g., 61%) which melted a t 87-93". The analytical sample was prepared by alternate recrystallization from methanol and ethyl ether-petroleum ether, m.p. 93.594.2'.Anal. Calcd. for C,sH?rOa: C, 72.13; H , 7.65. Found: C, 72.09; H, 7.73.Hydrogenation of II. A.-A solution of I1 (2.1 9.) in dioxane (50 ml.) was hydrogenated for four hours at 2800 p . s i . and 170-185" using palladium-on-strontium carbonate (2.1 8.) as a catalyst. The catalyst was filtered from the solution and the solvents removed to leave a brown solid residue. Recrystallization of this substance from benzene yielded three crops of unchanged hydroquinone I1 (0.57 g.) in various stages of purity. The filtrate from these cry\tallizations was separated by chromatographic fractionation to yield two major components: (1) quinone, m.p. 52-87' formed by air oxidation of I1 during processing and (2) an isomer bf 5,8dihydroxy-4a-methylperhydrophenanthrene, IVa (0.12 g.) which melted at 193.5-195" after recrystallization from acetone.Anal. Calcd. for CI6H26O1: C, 7...

show abstract

Aminopyridines

and¹,

Starker²

1962

Chemistry of Heterocyclic Compounds: A Series of Monographs

View full text Add to dashboard Cite

Antihistaminic Agents Containing a Thiophene Nucleus

Cited by 13 publications

References 1 publication

Vapour-liquid equilibrium study of tertiary amines, single and in blend with 3-(methylamino)propylamine, for post-combustion CO2 capture

Vapour-liquid equilibrium study of tertiary amines, single and in blend with 3-(methylamino)propylamine, for post-combustion CO2 capture

Notes

Aminopyridines

Contact Info

Product

Resources

About