Antihistamines prescribed off-label among paediatric patients at a tertiary care hospital setting in Malaysia

Tan, Rou Wei; Shah, Noraida Mohamed

doi:10.1007/s11096-016-0364-8

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Despite numerous available pharmaceutical products, the Food and Drug Administration (FDA) has only approved a quarter of them for use in children. However, due to a lack of pediatric medicine needs, licensed drugs for adults are being used off-label (5)(6)(7)(8). Drug management in pediatric patients is complex and insecure because limited information is available to validate stability, bioavailability, pharmacokinetics, pharmacodynamics, dosage precision, tolerance, and rebuilding ability (5,6).…”

Section: Introductionmentioning

confidence: 99%

Modified Omission of Prescriptions and Inappropriate Prescriptions (POPI) Criteria to Assess the Quality of Prescriptions to Pediatric Patients

Naserifar,

Arab Yousefiabadi,

Vahdati-Mashhadian

et al. 2023

Iran J Pediatr

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Background: In pediatrics, many drugs are used without marketing authorization. Recommendations are often based on clinical experience. Therefore, the risk of inappropriate prescription (IP) is high. It is necessary to have a tool for pediatric IP detection. Objectives: This study was performed to develop and validate a Pediatrics: Omission of Prescriptions and Inappropriate Prescriptions (POPI) screening tool to facilitate its use in pediatric practice in Iran. Methods: Using forward- and backward-translation procedures, an efficient and effective tool was provided in the current study and clinical settings. The two-round Delphi technique established content validity. The criteria were then piloted in a cross-sectional study in the pediatric patients of Khorasan Razavi and East Azerbaijan in Iran. Results: A total of 104 explicit criteria (79 IPs and 25 omissions) were obtained and submitted to an 18-member expert panel (including 8 pharmacists, 2 clinical pharmacists, and 8 pediatricians working in a hospital or the community). Then, 98 out of the 104 criteria submitted to the experts were selected after two Delphi rounds (75 IPs and 23 omissions). The content validity and reliability of the tool were obtained by expert assessment (Cronbach’s alpha for the entire criteria: 0.60). At least, the rate of one inappropriate prescribed medication was 69% in Mashhad, almost twice that of Tabriz (35%). Conclusions: The modified POPI criteria comprise the first screening tool to assess rational prescriptions for pediatric patients in hospital and outpatient settings. Clinical validation and reliability studies are needed and planned by the authors to evaluate the usability and reliability of this tool.

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Section: Introductionmentioning

confidence: 99%

Modified Omission of Prescriptions and Inappropriate Prescriptions (POPI) Criteria to Assess the Quality of Prescriptions to Pediatric Patients

Naserifar,

Arab Yousefiabadi,

Vahdati-Mashhadian

et al. 2023

Iran J Pediatr

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Attitudes, knowledge and views on off-label prescribing in children among healthcare professionals in Malaysia

2019

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Risk Minimization Measures in Off-Label Drug Use: A Survey of Community Pharmacists in Malaysia

Fatokun

2020

CDS

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Background: While off-label drug use is common and sometimes necessary, it also presents considerable risks. Therefore, measures intended to prevent or reduce the potential exposure to off-label risks have been recommended. However, little is known about community pharmacists’ beliefs regarding these measures in Malaysia. Objectives: This study examined community pharmacists’ beliefs towards risk minimization measures in off-label drug use in Malaysia and assessed the relationship between perceived risk of off-label drug use and beliefs towards risk minimization measures. Method: A cross-sectional survey was conducted among 154 pharmacists practicing in randomly selected community pharmacies in Kuala Lumpur and the State of Selangor, Malaysia. Results: Majority agreed or strongly agreed that adverse drug events from off-label drug should be reported to the regulatory authority (90.9%) and off-label drug should only be used when the benefit outweighs potential risks (88.3%). Less than half (48.1%) agreed or strongly agreed that written informed consent should be obtained before dispensing off-label drugs and a majority (63.7%) agreed or strongly agreed that the informed consent process will be burdensome to healthcare professionals. Beliefs towards risk minimization measures were significantly associated with perceived risk of off-label drug use regarding efficacy (p = 0. 033), safety (p = 0.001), adverse drug rection (p = 0.001), medication errors (p = 0.002). Conclusion: The community pharmacists have positive beliefs towards most of the risk minimization measures. However, beliefs towards written informed consent requirement are not encouraging. Enhancing risk perception may help influence positive beliefs towards risk minimization measures.

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Antihistamines prescribed off-label among paediatric patients at a tertiary care hospital setting in Malaysia

Cited by 3 publications

References 36 publications

Modified Omission of Prescriptions and Inappropriate Prescriptions (POPI) Criteria to Assess the Quality of Prescriptions to Pediatric Patients

Modified Omission of Prescriptions and Inappropriate Prescriptions (POPI) Criteria to Assess the Quality of Prescriptions to Pediatric Patients

Attitudes, knowledge and views on off-label prescribing in children among healthcare professionals in Malaysia

Risk Minimization Measures in Off-Label Drug Use: A Survey of Community Pharmacists in Malaysia

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