Antihistamines and their role as antipruritics

O’Donoghue, Michael; Tharp, Michael D.

doi:10.1111/j.1529-8019.2005.00034.x

Cited by 57 publications

(25 citation statements)

References 40 publications

(73 reference statements)

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“…The limited efficacy of antihistamines in most pruritic conditions 20,21 highlights the importance of histamine-independent mechanisms of itch. Mrgprs are among the most important mediators of histamine-independent itch.…”

Section: Discussionmentioning

confidence: 99%

Substance P activates Mas-related G protein–coupled receptors to induce itch

Azimi

Reddy

Pereira

et al. 2017

Journal of Allergy and Clinical Immunology

131

114

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Background Substance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing evidence that SP functions through Mas-related G protein–coupled receptors (Mrgprs) in addition to its conventional receptor, neurokinin-1. Objective Because Mrgprs mediate some aspects of inflammation that had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to determine whether itch induced by SP can also be mediated by Mrgprs. Methods Genetic and pharmacologic approaches were used to evaluate the contribution of Mrgprs to SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons from mice. Results SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons was dependent on Mrgprs rather than NK-1R. Conclusion We deduce that SP activates MrgprA1 on sensory neurons rather than NK-1R to induce itch.

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Section: Discussionmentioning

confidence: 99%

Substance P activates Mas-related G protein–coupled receptors to induce itch

Azimi

Reddy

Pereira

et al. 2017

Journal of Allergy and Clinical Immunology

131

114

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“…Antihistamines: First-generation antihistamines (hydroxyzine, diphenhydramine) and second-generation antihistamines (cetirizine, fexofenadine, loratadine) have been shown in randomized, controlled trials to have antipruritic effects [140]. Second-generation antihistamines are useful in the treatment of histamine-mediated pruritic conditions, such as chronic urticaria [141].…”

Section: Systemic Treatmentsmentioning

confidence: 99%

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

2015

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Chronic itch in the elderly is a common problem, with a significant impact on quality of life and sleep in elderly patients. Chronic itch may be attributable to several causes, including dry skin, immunosenescence and neural degeneration. Itch may also be caused by skin diseases, such as seborrhoeic dermatitis and stasis dermatitis; systemic conditions, such as end-stage renal disease and diabetes; and psychogenic conditions, such as depression and anxiety. The use of polypharmacy may also cause itch, with or without a rash. Specifically, thiazides and calcium channel blockers have been known to cause itch in elderly patients. Management should be tailored according to the underlying dermatological or systemic aetiology of itch. Topical treatment is the mainstay of therapy, providing special emphasis on skin hydration and barrier repair. In addition, topical and oral medications that target the nervous system and reduce neuronal hypersensitization, such as gabapentin and selective antidepressants, have a role in treating patients with severe chronic itch. Furthermore, management must account for changes in metabolism and pharmacokinetics of drugs in the aging population in order to prevent the occurrence of adverse effects.

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“…Pruritus following burns is a common and stressful complication after burn injury . The reported incidence of severe itching is as high as 87% in adult and 100% in pediatric burns patients . The pathophysiology of postburn pruritus is not well understood.…”

mentioning

confidence: 99%

Increased activity of TRPV3 in keratinocytes in hypertrophic burn scars with postburn pruritus

Kim

Cho

Park

et al. 2016

Wound Repair Regeneration

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Postburn pruritus is a common distressing sequela of burn wounds. Empirical antipruritic treatment often fails to have a satisfactory outcome, as the mechanism of it has not been fully elucidated. The aim of this study was to evaluate the manifestation of transient receptor potential vanilloid 3 (TRPV3), transient receptor potential ankyrin 1 (TRPA1), and other related receptors in postburn pruritus. Sixty-five burn patients with (n = 40) or without (n = 25) pruritus were investigated, including skin biopsies. Keratinocytes and fibroblasts from skin biopsy samples were separated. Real time-PCR showed that mRNA of TRPV3 was significantly increased in keratinocytes from pruritic burn scars than in keratinocytes from nonpruritic burn scars. With TRPV3 activation, intracellular Ca concentrations were more significantly increased in keratinocytes from pruritic burn scars than in those from nonpruritic ones. Additionally, mRNA and protein levels of protease-activated receptor 2 (PAR2) and neurokinin-1 receptor (NK1R) were also significantly increased in pruritic burn scars. In conclusion, it was confirmed that TRPV3, PAR2, and NK1R were highly expressed in pruritic burn scars. These results may help determine a novel mechanism for postburn pruritus.

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Antihistamines and their role as antipruritics

Cited by 57 publications

References 40 publications

Substance P activates Mas-related G protein–coupled receptors to induce itch

Substance P activates Mas-related G protein–coupled receptors to induce itch

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

Increased activity of TRPV3 in keratinocytes in hypertrophic burn scars with postburn pruritus

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