Antihistamine use in children

Fitzsimons, Róisín; Poel, Lauri‐Ann Van der; Thornhill, William; Toit, George Du; Shah, Neil; Brough, Helen A.

doi:10.1136/archdischild-2013-304446

Cited by 79 publications

(67 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Following this recommendation, 7 pediatric patients (mean age: 9.2 ± 2.3 years; M:F = 3: 4) with CSU between 3 months and 2 years, were started with cetirizine 2.5 or 5 mg twice a day, according to the licensed children’s dose (2–6 years 2.5 mg twice daily; 6–12 years 5 mg twice daily [2]). The patients were reviewed at weekly intervals for 4 weeks.…”

Section: Patientsmentioning

confidence: 99%

Antihistamines: Recommended Dosage – Divergence between Clinical Practice and Guideline Recommendations

Manti¹,

Salpietro²,

Cuppari³

2018

Int Arch Allergy Immunol

View full text Add to dashboard Cite

The updosing of second-generation antihistamines for chronic urticaria is based on inconsistent findings. Herein, we report data on the treatment of children with chronic spontaneous urticaria (CSU) unresponsive to single doses of second-generation H(1)-antihistamines in whom an increase in antihistamine was performed without improvement and with a high prevalence of adverse events. Thus, it appears that well-controlled, well-designed clinical trials are needed to clarify which nonsedating antihistamines should be used, in what dose, and for how long in patients not responding to the standard treatment, despite the improvement in health care that guidelines help to incorporate. Furthermore, a critical use of such guidelines should be done to improve the knowledge in CSU, especially in the pediatric population.

show abstract

Section: Patientsmentioning

confidence: 99%

Antihistamines: Recommended Dosage – Divergence between Clinical Practice and Guideline Recommendations

Manti¹,

Salpietro²,

Cuppari³

2018

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…That is, age of licensed use, frequency and dosing, clinical effects and possible side effects 43. Moreover, based on the lack of evidence of efficacy and the safety problem of the first-generation H 1 -antihistamines, Schad and Skoner44 stated that the paediatric use of first-generation antihistamines should even be restricted to two uncommon situations.…”

Section: Discussionmentioning

confidence: 99%

Are antihistamines effective in children? A review of the evidence

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Moreover, not all formulations of these drugs are acceptable for children. An ideal oral antihistamine of the second generation dedicated to paediatric patients should meet the following criteria [59][60][61]:…”

Section: Antihistamines In Paediatric Patients and Patients With Asthmamentioning

confidence: 99%

The role and choice criteria of antihistamines in allergy management – Expert opinion

Kuna

Jurkiewicz

Czarnecka‐Operacz

et al. 2017

Alergologia Polska - Polish Journal of Allergology

View full text Add to dashboard Cite

A b s t r a c tAllergic diseases are the most common chronic conditions lasting throughout the patient's life. They not only cause significant deterioration in the quality of life of patients but also lead to significant absenteeism and reduced productivity, resulting in very high costs for society. Effective and safe treatment of allergic diseases is therefore one of the main challenges for public health and should be carried out by all the specialists in family medicine, internists and paediatricians in collaboration with allergists, otorhinolaryngologists and dermatologists. Antihistamines are most commonly used in the treatment of allergies. Several dozen drugs are available on the pharmaceutical market, and their generic forms are advertised widely as very effective drugs for the treatment of allergic diseases. What is the truth? What are the data from clinical trials and observational studies? Are all drugs equally effective and safe for the patient? According to a panel of experts representing various fields of medicine, inappropriate treatment of allergies can be very risky for patients, and seemingly equally acting medications may differ greatly. Therefore, a panel of experts gathered the latest data from the entire scientific literature and analysed the latest standards and recommendations prepared by scientific societies. This paper provides a summary of these studies and highlights the importance for the patient of the proper choice of drug to treat his allergies.Key words: antihistamines, bilastin, allergic rhinitis, urticaria, allergy. Which antihistamines should be chosen according to current standards and recommendations?In the last few decades the incidence of allergic diseases has grown to epidemic status. According to the current data, more than 600 million people suffer from allergic rhinitis worldwide, approximately 25% of them in Europe. In the ECAP trial (Epidemiology of Allergic Diseases in Poland) as many as 30% of respondents reported allergic rhinitis, less than 7% mentioned urticaria, but over 40% of patients had positive skin tests with common inhaled allergens (e.g. plant pollen, dust mites, mould and animal hair). Despite this huge number of patients, these data are frequently underestimated, since allergic diseases are generally believed to be trivial and non-hazardous. However, it has already been proven that allergic rhinitis, asthma and urticaria are associated with a significant socioeconomic burden all over the world -regardless of region, development level and financial status. The total cost of allergic diseases brings both reduced quality of life and also direct costs of drugs and health services as well as indirect social costs such as the absence from work; it also decreases productivity and concentration and generates learning disorders and

show abstract

Antihistamine use in children

Cited by 79 publications

References 43 publications

Antihistamines: Recommended Dosage – Divergence between Clinical Practice and Guideline Recommendations

Antihistamines: Recommended Dosage – Divergence between Clinical Practice and Guideline Recommendations

Are antihistamines effective in children? A review of the evidence

The role and choice criteria of antihistamines in allergy management – Expert opinion

Contact Info

Product

Resources

About