Antihistamine Treatment of Acute Nephritis

Effect of an Antihistamine (Chlorprophenpyridamine Maleate) on Experimental Nephrotoxic Nephritis in Rats

“…The experiences reported in the English literature on the clinical and experimental use of anti-histamines in nephritis have been limited and conflicting. Mepyramine maleate (Anthisan) used in two groups of patients produced slight benefit in one group (4) and no change in the other group (5). Experimentally, tripelennaminc hydrochloride (Pyribenzamine) has been shown to delay the onset of albuminuria, but not to alter the histologic findings in nephro-toxic nephritis (6).…”