Antihistamine blockade of alcohol-induced flushing in orientals.

Prevalence of self‐reported hypersensitivity symptoms following intake of alcoholic drinks

“…Flushing in Asians correlates with increased levels of acetaldehyde following alcohol intake [56]. Pre-treatment with antihistamines reduces flushing in patients with alcohol-induced flushing undergoing an ethanol challenge, emphasizing a key role of histamine in these reactions [57].…”

ALDH2 Status, Alcohol Expectancies, and Alcohol Response: Preliminary Evidence for a Mediation Model

“…Each participant completed two laboratory sessions (approximately 5 hr each), which were identical in format except for the alcohol dose administered. All participants were given verbal and written instructions to refrain from alcohol use for 24 hr before each session, to refrain from cigarette smoking for 2 hr before each session, and to refrain from other drug use, including aspirin, antihistamines, and nonsteroidal antiinflammatory agents, which can alter the alcohol flush reaction (Miller et al, 1988;Truitt et al, 1987), for 48 hr before each test session.…”

Histaminergic Modulation of Body Temperature and Energy Expenditure

“…Similarly, combined H1R and H2R antagonists diminish the alcohol-induced flushing in individuals of Oriental origin [55].…”