Antihepatoxic constituents ofGarcinia kola seeds

Iwu, Maurice M.

doi:10.1007/bf02007729

Cited by 143 publications

(95 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Extraction of Kolaviron was achieved by the procedure previously described by Iwu (1985) [5], and modified by Braide (1991) [18]. Briefly, Garcinia kola seeds were peeled and air dried in the laboratory (25)(26)(27)(28) 0 C) and ground into powdered form.…”

Section: Extraction Of Kolavironmentioning

confidence: 99%

See 1 more Smart Citation

Neuroprotective Effects of Kolaviron, a Biflavonoid Complex of <i>Garcinia kola</i>, on Rats Hippocampus against Methamphetamine-Induced Neurotoxicity

Ijomone¹,

Nwoha²,

Olaibi³

et al. 2012

Macedonian Journal of Medical Sciences

View full text Add to dashboard Cite

Aim: To investigate the protective effects of kolaviron on brain weight and behavioural performance and the histology of the hippocampus of adult Wistar rats following methamphetamine challenge. Materials and Methods:Twenty four adult Wistar rats weighing between 150-200 g, randomly assigned into four groups of six each (Groups A, B, C, D) were used for this research. Group A served as control, while groups B and C were given single dose methamphetamine (10 mg/kg) intraperitoneally after group C was pre-treated with kolaviron (200 mg/kg) for 7 days and group D received cornoil (vehicle for kolaviron) only.Results: High level of methamphetamine-induced stereotypic movement was observed, and the onset was delayed by kolaviron administration. Animals administered methamphetamine only, showed significantly poor behavioural performance on the water maze after treatment when compared to the other groups (P<0.05). Histological analysis revealed neuronal destruction of the pyramidal layer of the hippocampus following methamphetamine administration. Kolaviron to some extent prevented destruction of pyramidal cells of the hippocampus in pre-treated rats. Conclusion:The present findings show the neuro-destructive effects of methamphetamine on hippocampal neurons and its ability to negatively affect behaviour and that kolaviron could prevent such behavioural deficit and also afford some protection to the hippocampus.

show abstract

Section: Extraction Of Kolavironmentioning

confidence: 99%

“…Studies have also reported the use of this plant for the treatment of jaundice, high fever, purgative and as chewing stick. The plant also found usefulness in the treatment of stomach ache and gastritis [5,6]. The phytochemical compounds isolated from G. kola include oleoresin, tannins, saponins, alkaloids, cardiac glycosides.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Kolaviron, a Biflavonoid Complex of <i>Garcinia kola</i>, on Rats Hippocampus against Methamphetamine-Induced Neurotoxicity

Ijomone¹,

Nwoha²,

Olaibi³

et al. 2012

Macedonian Journal of Medical Sciences

View full text Add to dashboard Cite

show abstract

“…Extraction of Kolaviron was achieved by the procedure previously described by Iwu (1985) and modified by Braide (1991). The outer cover of Garcinia kola seeds were peeled, sliced and air-dried in the laboratory (25-28 ºC) and grounded into powdered form.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Antioxidant Effects of Kolaviron and Vitamin C Interventions on Testicular Structures Following Nevirapine Administration in Sprague-Dawley Rats

et al. 2016

View full text Add to dashboard Cite

SUMMARY:Testicular toxicity has been implicated in highly active anti-retroviral therapy (HAART) treatment. Hence there is need to identify an effective antioxidant product that can alleviate testicular necrosis due to HAART administration. Forty eight adult male Sprague-Dawley rats were used in this study. The animals were divided into eight (8) groups: A-H (n= 6). Group A animals received normal saline as the control; Group B was given Nevirapine (Nv); Group C was given Kolaviron (Kv); Group D was given vitamin C; Group E was given Nv and Kv; Group F was given Nv and Vitamin C; Group G was given Nv for 56 d and Kv for 28 d serving as a withdrawal group; Group H was given corn oil. Nv, Kv and Vit. C were given at 1.54, 200 and 250 (mg·kg)/bw respectively while all administrations were through oral gavage. The body weights were taken every other day. Thereafter, they were anaesthetized with halothane. The testes were excised, weighed, fixed in Bouin's fluid and stained with H&E while the epididymes removed for semen fluid analyses. The results showed a significant (P<0.05) decrease in sperm motility in group E (Nevirapine + kolaviron) when compared with group F (Nevirapine + Vitamin C) while Sperm count was not significantly different (P>0.05) across the groups. The testicular histoarchitectural studies revealed indistinct spermatogonia, necrotic interstititial endocrine cells in the altered interstitial space, fragmented spermatids, atrophy of mature spermatocytes, degenerated germ cells, obliterated seminiferous tubules lumen, undifferentiated spermatogonia and cellular debris in the somniferous tubules lumen of nevirapine administered group but normal across the other groups. In the testis, there were no significant reduction in SOD, Catalase and GPx activities but a significant decrease in GST activity (P<0.001) when group E was compared with group F. In conclusion, vitamin C presents a better remediation in nevirapine induced spermiotoxicity compared to kolaviron in Sprague-Dawley rats.

show abstract

“…The seed has also been shown to be useful as bronchodilator and antimicrobial in the treatment of bronchitis, throat troubles, heart diseases and urinary tract infections (Irvine, 1961;Iwu, 1985Iwu, , 1986Iwu, , 1993Iwu, Igboko, Elekwa & Tempesta, 1990). Ebana, Madunagu, Ekpe and Otung (1991) investigated the antimicrobial, antibacterial and antiviral properties while Iwu (1999) stated that Garcinia kola seed can be used as adaptogen and anti-inflammatory agent as well as in the cure of flu and influenza.…”

Section: Introductionmentioning

confidence: 99%

“…7, No. 2;2015 antioxidant properties (Ejele, 2010;Ejele & Akujobi 2011;Ejele, Nwaeze & Alinnor 2012a, Arekemase, et. al, 2012Daramola, Adegoke & Osonyinlusi,, 2012;A.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Chemical Properties of Chromatographic Fractions of Acidic Metabolites from Garcinia Kola Seed Extract

Uka

Okoroiwu

Onu

et al. 2015

IJC

View full text Add to dashboard Cite

Acidic metabolites were precipitated from ethanolic extract of Garcinia kola seed and fractionated by column chromatography to obtain three fractions AM1, AM2, and AM3. Chemical test on the acidic metabolites and the fractions showed they were mainly flavonoids. In vitro antibacterial screening of the fractions showed they possessed antibacterial activity. They inhibited the growth of five human test bacterial isolates: Coliform bacilli, Escherichia coli, Salmonella spp., Staphylococcus aureus and Streptococcus spp. Their inhibition zone diameters ranged from 8 mm to 26 mm. The standard control antibiotic Ciprofloxacin gave inhibition zone diameters ranging from 18 mm to 20 mm, at the same concentration of 100 mg/ml for the same test bacteria. It was concluded that with appropriate standardization, the three fractions from the acidic metabolites of ethanolic extract of seed of Garcinia kola could effectively complement the existing antibiotics with beneficial health effect.

show abstract

Antihepatoxic constituents ofGarcinia kola seeds

Abstract: Kolaviron, a fraction of defatted methanolic extract and biflavanones of Garcinia kola seeds significantly antagonized the lethal poisoning of mice with phalloidin. Garcinia biflavanones GB1, GB2 and kolaflavanone were isolated as the active constituents.

Cited by 143 publications

References 7 publications

Neuroprotective Effects of Kolaviron, a Biflavonoid Complex of <i>Garcinia kola</i>, on Rats Hippocampus against Methamphetamine-Induced Neurotoxicity

Neuroprotective Effects of Kolaviron, a Biflavonoid Complex of <i>Garcinia kola</i>, on Rats Hippocampus against Methamphetamine-Induced Neurotoxicity

Comparison of Antioxidant Effects of Kolaviron and Vitamin C Interventions on Testicular Structures Following Nevirapine Administration in Sprague-Dawley Rats

Antibacterial and Chemical Properties of Chromatographic Fractions of Acidic Metabolites from Garcinia Kola Seed Extract

Contact Info

Product

Resources

About