Antihepatotoxic and immunostimulant properties of iridoid glycosides of <i>Scrophularia koelzii</i>

Garg, H. S.; Bhandari, S. P. S.; Tripathi, Shashank; Patnaik, G. K.; Puri, Anju; Saxena, Richa

doi:10.1002/ptr.2650080407

Cited by 38 publications

(24 citation statements)

References 11 publications

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“…These results were supported by histological studies. Iridoid glycosides from many plants are known for their antihepatotoxic and antioxidant effect (Garg et al, 1994), respectively. They are considered to be the active principles of many medicinal plants (Ghisalberti, 1998;Dinda et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and hepatoprotective effect of swertiamarin from Enicostemma axillare against d-galactosamine induced acute liver damage in rats

Jaishree

Badami

2010

Journal of Ethnopharmacology

136

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Section: Discussionmentioning

confidence: 99%

Antioxidant and hepatoprotective effect of swertiamarin from Enicostemma axillare against d-galactosamine induced acute liver damage in rats

Jaishree

Badami

2010

Journal of Ethnopharmacology

136

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“…While both compounds 232 and 233 showed a negative dose-dependent response, stimulating HDF growth at lower concentration (highest at 0.78 mg/ml). Scopolioside A was also found to possess immunostimulant property 119) and compound 232 anti-inflammatory activity. 120) Hence the use of the extract of S. nodosa containing these compounds for wound healing treatment as folk medicine is justified.…”

Section: )mentioning

confidence: 99%

Naturally Occurring Secoiridoids and Bioactivity of Naturally Occurring Iridoids and Secoiridoids. A Review, Part 2

Debnath²,

2007

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This is a second part of a review 1) and is mainly a compilation of new secoiridoids reported in the literature during 1994-2005 as well as a high-light of biological and pharmacological activity of iridoids and secoiridoids published during 1998--2005. The earlier first part of review 1) included new naturally occurring iridoids (glycosides, aglycones, derivatives and dimers) reported during 1994-2005. Secoiridoids are monoterpenoids based on the 7,8-secocyclopenta[c]-pyranoid skeleton and represented by 1a. They are possibly derived in plants from iridoid, loganin 1b by oxidative cleavage with redox enzyme to 1c and then undergo various secondary modifications of the basic skeleton namely, epoxidation, oxidation, hydroxylation and esterification of the generated hydroxyl groups leading a group of compounds which constitute the class. The main aim of this review is for rapid identification of isolated secoiridoids by comparison of spectral data as well as to draw attention of the natural product chemists for evaluation of biological and pharmacological activity of the isolated iridoids and secoiridoids in order to justify the use of medicinal plants containing these metabolites in folk medicines. In certain plants, the isolated metabolites showed biological activities other than the use of the concerned plants in traditional system of medicine. The high-light of pharmacological activity may possibly draw the attention of the synthetic chemists for design of new drugs using known iridoids as raw materials.A number of review articles on plant secoiridoids are available. Listings of naturally occurring secoiridoids together with spectroscopic data and plant source (review of El-Naggar and Beal covering the literature through January, 1980 2) and of Boros and Stermitz covering the literature through December, 1989 3) ), and without spectroscopic data (review of Hazimi and Alkhathlan covering through December, 1993 4) ) are available. The reviews on biological activity of plant iridoids, namely of Sticher, covering the works reported up to 1976, 5) of Ghisalberti and of Mandal et al. covering the literature up to a part of 1997 6,7) are also available. Secoiridoids are listed in Table 1 in a fashion similar to that of the Boros and Stermitz review.3) All the new secoiridoids are arranged in four groups. Group 1 contains simple secoiridoids; whereas group 2 contains terpene-conjugated secoiridoids; group 3 contains aromatic conjugated secoiridoids and group 4 contains bis-, tris-and tetrakis-secoiridoids. The oxidation state of C-10 and C-11 guides the arrangement of compounds in each group except group 4. The available data for each compound were listed in the following order: name; structure; molecular formula; calculated molecular weight as per atomic weight of most abundant isotopic atoms of C, H, O, etc.; melting point (°C); optical rotation, [a] D (with concentration and solvent); UV (solvent, l max in nm, log e); IR (medium, n max in cm C-NMR data to the first decimal point. Assignments with the s...

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“…The iridoids are groups of natural molecules with a monoterpene cyclic ring, found in a wide variety of plants (Tietze, 1983). The previous phytochemical studies reported that iridoid glucoside possesses a number of activities such as antitumoral, hypotensive, sedative and hepatoprotective activities (Garg et al, 1994;Ghisalberti, 1998). The in vitro effects of SPC have been reported earlier while the limited in vivo effects have been studied.…”

Section: Introductionmentioning

confidence: 97%

Specioside ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans

Asthana

Yadav

Pant

et al. 2015

Comparative Biochemistry and Physiology Part C: Toxicology &

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Antihepatotoxic and immunostimulant properties of iridoid glycosides of Scrophularia koelzii

Cited by 38 publications

References 11 publications

Antioxidant and hepatoprotective effect of swertiamarin from Enicostemma axillare against d-galactosamine induced acute liver damage in rats

Antioxidant and hepatoprotective effect of swertiamarin from Enicostemma axillare against d-galactosamine induced acute liver damage in rats

Naturally Occurring Secoiridoids and Bioactivity of Naturally Occurring Iridoids and Secoiridoids. A Review, Part 2

Specioside ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans

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