Antihepatotoxic activity of ferolactone, a new furanocoumarin from Feronia limonia

A phytochemical investigation on the stems and leaves of Clausena lenis led to the isolation of a new furanocoumarin, clauselenisin A (1), together with five known analogues (2-6). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All known compounds (2-6) were isolated from C. lenis for the first time. All isolated compounds were evaluated for their their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-6 showed significant antiproliferative effects with IC values ranging from 0.36 to 16.48 μM.

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Furanocoumarins with potential antiproliferative activities from Clausena lenis

Liu

Wen

et al. 2018

Natural Product Research

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Antihepatotoxic activity of ferolactone, a new furanocoumarin from Feronia limonia

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Furanocoumarins with potential antiproliferative activities from Clausena lenis

Furanocoumarins with potential antiproliferative activities from Clausena lenis

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