“…Ventricular septa1 defects, aortic arch anomalies, and double outlet right ventricle were the most common cardiovascular malformations observed. These results were similar to our previous finding using adult rat heart antiserum, and suggest that AFHS alone is not teratogenic, but when combined with a sub-teratogenic dose of AKS it becomes teratogenic and organ specific.There have been several reports on induction of cardiovascular malformations by administering anti-heart sera to pregnant rats or mice, but the malformation rate has been generally low (Barrow and Taylor, 1971;Nora et al, 1974;Miyata et al, 1984).However, when direct impairment of fetal organs is considered, administration of antiserum to fetal tissue itself may produce severe anomalies. In the present experiments, pregnant rats were administered anti-fetal-heart serum alone or in combination with a sub-teratogenic dose of antikidney serum in order to compare the results of the administration of rabbit anti-adult-rat-heart serum (AAHS).…”