Antigens of the major histocompatibility complex in patients with chronic discoid lupus erythematosus

Knop, J.; Bonsmann, Gisela; Kind, Peter; Doxiadis, Ilias; Vögeler, U.; Doxiadis, G.; Goerz, G.; Grosse‐Wilde, H.

doi:10.1111/j.1365-2133.1990.tb06258.x

Cited by 32 publications

(13 citation statements)

References 25 publications

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“…An association with HLA-B7, B8, Cw7, DR2, DR3 and DQw1 has been described, along with an increased risk of developing the disease in certain gene combinations, such as HLA-Cw7, DR3, DQw1 and HLA B7, HLA-Cw7 and DR3 [13]. …”

Section: Discussionmentioning

confidence: 99%

Association between Discoid Lupus erythematosus and Cigarette Smoking

Miot¹,

Miot²,

Haddad

2005

Dermatology

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Background: Discoid lupus erythematosus (DLE) is a chronic cutaneous disease affecting photoexposed areas and has also been associated with cigarette smoking. Objective: To evaluate the association between smoking and DLE. Methods: A case-control study was performed involving 57 cases diagnosed with DLE and 215 healthy controls. Results: A higher smoking prevalence was noted in DLE cases (84.2%) than controls (33.5%), and the odds ratio adjusted for gender, age and ultraviolet index in the city of origin was 14.4 (95% confidence interval 6.2–33.8; multiple logistic regression, p < 0.01). The cumulative smoking exposure was not related to premature DLE development. At the beginning of the disease, smokers had more extensive involvement than nonsmokers; compromise of the upper arms was statistically related to smoking. Conclusion: Cigarette smoking was statistically associated with DLE development. Other studies are needed in order to evaluate the effects of smoking cessation on the course of disease.

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Section: Discussionmentioning

confidence: 99%

Association between Discoid Lupus erythematosus and Cigarette Smoking

Miot¹,

Miot²,

Haddad

2005

Dermatology

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“…The class II MHC genes, HLA‐DRB1 and HLA‐DQ, have been associated in autoantibody production. These genes are extremely polymorphic, and allelic variants from these loci have been associated with CDLE in white European patients 9,10 …”

Section: Introductionmentioning

confidence: 99%

Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients

et al. 2007

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“…In CDLE, an association between HLA‐Cw6 and CDLE has not been documented in the Japanese population, and the HLA‐A33‐B44‐DRB1*1302 haplotype showed a positive association. Reports from European countries suggest that combinations were found in 17.2% of HLA‐Cw7, DR3, DQw1 and HLA‐B7, Cw7 and DR3 were found in 17.2% of CDLE and in 2.3% of the controls, 11 and the association of CCLE with certain HLA class II alleles points to an involvement of HLA‐DQ and/or ‐DR molecules (HLA‐DRB1*1601‐DQA*0102) in the pathogenesis of CDLE, 12 which is different from the present Japanese result.…”

Section: Genetic Basis Of Japanese Patients With Cutaneous Lementioning

confidence: 99%

Race Differences in Immunogenetic Features and Photosensitivity of Cutaneous Lupus Erythematosus from the Aspect of Japanese Studies

Furukawa

Yamamoto

Kanazawa

et al. 2009

Annals of the New York Academy of Sciences

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Skin lesions of collagen diseases are influenced by environmental triggers, such as UV light, and are variable in cutaneous lupus erythematosus (LE), such as systemic LE (SLE), chronic discoid LE (CDLE), subacute cutaneous LE (SCLE), and LE tumidus (LET). Although there are a few conflicting reports on photosensitivity in collagen diseases, many Japanese dermatologists feel there are photosensitivity differences in LE between Asians and Caucasians with SCLE and LET. To address this issue, we have carried out genetic studies of Japanese SLE and CDLE patients and reviewed the race differences in photosensitivity of cutaneous LE from Japanese studies. Human leukocyte antigen (HLA) studies in Japanese patients revealed that HLA-DRB1*1501 association was with CDLE and SLE. The association between HLA-Cw6 and CDLE was first reported in a Japanese population, and a HLA-A33-B44-DRB1*1302 haplotype showed a positive association in CDLE. However, these results are not compatible with those from Caucasian subjects. There are no significant associations among HLA studies, photosensitivity, and anti-Ro/SS-A antibodies in Japanese CLE patients. Photosensitivity will be a key factor to dissolve multifactorial complexes of LE etiopathogenesis. An axis of photosensitivity, anti-Ro/SS-A antibodies, and apoptosis via tumor necrosis factor-alpha is the best marker to verify the contribution of genetics in CLE patients. The incidence and degree of photosensitivity of SCLE and LET are much lower in Japanese than in Caucasians. This discrepancy may lead to investigations of CLE pathogenesis through global collaborations.

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Antigens of the major histocompatibility complex in patients with chronic discoid lupus erythematosus

Cited by 32 publications

References 25 publications

Association between Discoid Lupus erythematosus and Cigarette Smoking

Association between Discoid Lupus erythematosus and Cigarette Smoking

Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients

Race Differences in Immunogenetic Features and Photosensitivity of Cutaneous Lupus Erythematosus from the Aspect of Japanese Studies

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