Antigens Induced By The Mouse Leukemia Viruses

Pasternak, G

doi:10.1016/s0065-230x(08)60328-0

Cited by 37 publications

(13 citation statements)

References 101 publications

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“…Most experimentally induced leukaemias express neoantigens detectable serologically or by in vivo transplantation procedures (Pasternak, 1969). In the present study only 2 of 5 transplanted leukaemias provided any evidence of immunogenicity, and this was weak.…”

Section: Discussioncontrasting

confidence: 54%

Cell surface antigen expression on chemically induced murine leukaemias

Birch¹,

Moore²,

Craig³

1975

Br J Cancer

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The immunogenicity of murine leukaemias induced by chemical carcinogens or irradiation in C57Bl or (C57Bl times DBA2) F1 hybrid mice has been studied in vivo by transplantation and in vitro by indirect membrane immunofluorescence (IF) using syngeneic immune or allogeneic immune antisera. Two of 5 leukaemias tested for immunogenicity by assessment of the capacity of syngeneic mice specifically immunized with irradiated (3 Krad) cells to reject small challenge inocula (10(3)-10(4) cells) displayed weak neoantigenicity while 3 were non-immunogenic by this criterion. Antibodies directed against cell-surface antigens of the immunizing cells of 7 leukaemias were not detectable by immunofluorescence tests using sera from the respective immunized mice. H-2 histocompatibility antigens readily identified on normal lymphoid cells using reference Balb/c anti-C57Bl (H-2d anti-H-2b) alloantisera could neither be detected on the majority of transplanted leukaemias nor on 9 primary leukaemias in C57Bl mice induced by N-butyl-N-nitrosourea (BNU). Two of the transplanted leukaemias showed greatly diminished capacity for absorption of alloantibody compared with normal spleen cells. Transplantation to H-2 different recipients, in which the leukaemic cells were invariably rejected, generated a strong humoral antibody response, which was demonstrable against normal lymphoid cells. Failure to demonstrate significant antibody binding by indirect immunofluroescence tests with immune sera, or by absorption, is presented as evidency that H-2 antigen expression is substantially modified on BNU induced leukaemia cells. These findings have implications for the detection of tumour neoantigens on chemically induced leukaemias.

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Section: Discussioncontrasting

confidence: 54%

Cell surface antigen expression on chemically induced murine leukaemias

Birch¹,

Moore²,

Craig³

1975

Br J Cancer

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“…In this way, tumors which are weakly or non-antigenie, can become strongly antigenie by virus infeetion. This has been observed in tnouse and rat tutnors infected with sendai, hetpes, polyoma, SV 40, tnouse leuketnia (Pasternak 1969, Kobayashi 1970 and sareotna (Basombrio 1972) viruses. A stumbling block in tumor immunology is tbat many tutnors may not be immunogenie.…”

Section: Antigetis Of Virtts-lttduced Tumorsmentioning

confidence: 80%

“…At every step in stud-ies of tumor virology, imtnunological methods are used to recognize virus presence and in many cases these new antigens are the only experimental marker for the presence of a virus. Habel (1961) and Sjogren et al (1961) first reported that mice immunized with polyoina virus became resistant to grafts of polyoma-induced tumors and this type of resistance was confirmed for other oncogenic viruses (Pasternak 1969, Klein 1966. It was soon observed that, iti contrast with fhe chemically-induced tumors, all tumors independently induced by a particular oncogenic virus cross-reacted among them.…”

Section: Antigetis Of Virtts-lttduced Tumorsmentioning

confidence: 94%

The immunology of cancer

Basombrío

1973

J Oral Pathology Medicine

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“…Sci. USA 69 (1972) tumor cells induced by the same virus (for reviews see [59][60][61][62]. In the EBV system it is puzzling, however, that membrane antigen is also a component of the viral envelope (63,64).…”

Section: Irradiation Of Bl and Nasopharyngeal Carcinoma In Vivo Hasmentioning

confidence: 99%

Herpesviruses and oncogenesis

Klein¹

1974

Nature

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Antigens Induced By The Mouse Leukemia Viruses

Cited by 37 publications

References 101 publications

Cell surface antigen expression on chemically induced murine leukaemias

Cell surface antigen expression on chemically induced murine leukaemias

The immunology of cancer

Herpesviruses and oncogenesis

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