Antigenotoxic and antimutagenic effects of Myrciaria dubia juice in mice submitted to ethanol 28-day treatment

Silva, Francisco Carlos da; Picada, Jaqueline Nascimento; Romão, Natália Faria; Sobral, Fabiana de Oliveira Solla; Lemos, Daniela Lucas da Silva; Schons, Sandro de Vargas; Mello, Taciane Letícia de; Silva, Waldiene Melo; Oliveira, Rafaela da Silva; Lucas, Cláudia Perboni; Pereira, Patrı́cia; Chaves, Vítor Clasen; Reginatto, Flávio Henrique; Ferraz, Alexandre de Barros Falcão

doi:10.1080/15287394.2019.1671279

Cited by 11 publications

(4 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was observed that the extract reduced up to 37 % of the chromosomal breaks, suggesting its antimutagenic potential [15] . These antimutagenic and antigenotoxic effects observed in the species may be related to the presence of compounds such as phenols and anthocyanins, which stimulate DNA repair pathways and have an antioxidant nature [14,16] …”

Section: Introductionmentioning

confidence: 98%

“…The seeds of M. dubia are rich in phenolic compounds such as rosmarinic acid, ellagic acid, quercetin, trans‐ resveratrol, [15] gallic acid, cyanidin‐3‐ O ‐glucoside, malvidin‐3,5‐diglucoside, [25] chlorogenic acid, p‐ coumaric acid, ferulic acid, rutin, [26] syringic acid and caffeic acid [27] . Thus, in samples of its fruits, several compounds such as quercetin, myricetin, ellagic acid, caffeic acid, gallic acid, ferulic acid, p‐ coumaric acid, [21] ascorbic and dehydroascorbic acid [24] and anthocyanins such as cyanidin‐3‐ O ‐glucoside and delphinidin‐3‐ O ‐glucoside [16] have already been identified. Extracts from the fruits of Myrciaria vexator have flavonoids, tannins, and ascorbic acid in their composition, in addition to an important content of iron, calcium, and phosphorus [45] ( Figure 2).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Myrciaria Genus: Bioactive Compounds and Biological Activities

Pereira

Charret

Machado

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

The Myrtaceae family is of angiosperms, imposing its size and economic, cultural, and scientific importance. The genus Myrciaria, belonging to this family, has 33 species currently accepted, many of which are research targets aimed at elucidating their bioactive compounds and biological activities. Most species of the Myrciaria genus have terpenes in their composition, mainly mono and sesquiterpenes, and phenolic compounds such as tannins, phenolic acids, and flavonoids. Other secondary metabolites are also observed, such as alkaloids, steroids, coumarins, saponins, and naphthoquinones. These bioactive compounds are closely related to these species′ most diverse biological activities: antioxidant, anti‐inflammatory, analgesic, antiproliferative, antimicrobial, antiparasitic, insecticide, metabolic, protective, and nutraceutical. This work aims to provide a review of secondary metabolites and medicinal properties related to the genus Myrciaria, thus stimulating further studies on the species of this genus.

show abstract

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Myrciaria Genus: Bioactive Compounds and Biological Activities

Pereira

Charret

Machado

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…13,14 A recent work links the presence of ascorbic acid and anthocyanins to the antigenotoxic and antimutagenic effects of M. dubia fruits, which protect DNA against damage induced by ethanol. 15 These features point to a great promise in the research for new medical drugs based on synthetic or natural molecules with antioxidant, antinociceptive, and antiedematogenic effect. 16,17 Based on these evidences, the aim of the present study is to evaluate the antinociceptive and anti-inflammatory potential of M. dubia fruits.…”

Section: Introductionmentioning

confidence: 99%

Myrciaria dubia Juice (camu-camu) Exhibits Analgesic and Antiedematogenic Activities in Mice

Silva

Souza

Bassoli

et al. 2021

Journal of Medicinal Food

Self Cite

View full text Add to dashboard Cite

The Myrciaria dubia (Myrtaceae) fruit is traditionally used to treat malnutrition due to its high levels of vitamin C and phenolic compounds. Because of its composition, this plant is very promising in the research of novel natural treatment for pain disorders. This study analyzed the phytochemical profile of M. dubia juice and assessed its antinociceptive and antiedematogenic potential. The phytochemical profile was determined through high-performance liquid chromatography (HPLC), the oral antinociceptive effect of M. dubia 50% juice (Md50) was evaluated by formalin, hot plate and Complete Freund's Adjuvant tests and the antiedematogenic activity by paw edema. HPLC revealed the presence of ascorbic acid, rutin, and ellagic acid as major compounds. Md50 showed an antinociceptive effect in the acute and chronic phases of the formalin test. In the hot plate test, Md50 also induced an antinociceptive effect of 0.5 up to 6 h, showing antinociceptive and antiedematogenic potential without changing the spontaneous locomotion of animals. All protocols were submitted and approved by the Ethics Committee for use of Animals of the Lutheran University of Brazil (protocol No. 2013-30P).

show abstract

“…Moreover, the bioactive compounds can minimize the risk of incidence of some chronic diseases because they demonstrate antigenotoxic and anti-inflammatory properties (Fidelis et al 2020;Silva et al 2019), neuroprotective effects (Azevêdo et al 2015), antihyperglycemic and antihypertensive activity (Fidelis et al 2020;Fujita et al 2015), chromosome damage prevention (Carmo et al 2019), antimalaria potential, and schistosomicidal activity (Carmo et al 2020). As a consequence of such benefits, the demand for this species has increased significantly, leading to the need for the development of cultivation practices-in particular, more efficient propagation methods for multiplication, conservation, and regeneration of this species.…”

mentioning

confidence: 99%

Somatic Embryogenesis of Myrciaria dubia (Kunth.) McVaugh

Chagas¹,

Crane

Chagas

et al. 2023

horts

View full text Add to dashboard Cite

Myrciaria dubia (caçari or camu-camu) is a species with great relevance because of its high levels of bioactive compounds and antioxidant activity. The species is propagated mainly by seed, which leads to high genetic diversity. Producing plants that maintain their characteristics on a large scale at a low cost is a challenge for fruit species, especially in the Myrtaceae family. Therefore, this study aimed at assessing the effects of different plant growth regulators at various concentrations for the induction of somatic embryogenesis from caçari nodal segments and leaf disk explants. Two independent experiments were performed using nodal segments and leaf disks from plants grown in the greenhouse. In the first experiment, the combined effect of auxin and cytokinin at different concentrations was evaluated: 2,4-dichlorophenoxyacetic acid at 0, 1, 2, and 4 mg⋅L–1; and benzylaminopurine at 0, 0.25, 0.5, and 1 mg⋅L–1). In the second experiment, the application of different plant growth regulators (benzylaminopurine, kinetin, thidiazuron, and isopentenyl adenine) and their concentrations (0, 2, 4, and 6 mg⋅L–1) were evaluated. In both experiments, the basic culture medium was woody plant medium. Callus formation via nodal segments and leaf disks occurred in the first 30 d from cultivation and proved to be responsive to induction by 2,4-dichlorophenoxyacetic acid and benzylaminopurine. Auxin proved to be essential for somatic embryogenesis induction in nodal segments using 1 and 4 mg⋅L–1 of 2,4-dichlorophenoxyacetic acid alone. The results of this experiment will help advancing protocols for regeneration of somatic embryos and elucidating the physiological, molecular, and genetic mechanisms involved in the process of somatic embryogenesis for M. dubia. The development of an efficient protocol for in vitro clonal propagation of this species also lays the groundwork for further optimization of the system for genetic transformation.

show abstract

Antigenotoxic and antimutagenic effects of Myrciaria dubia juice in mice submitted to ethanol 28-day treatment

Cited by 11 publications

References 53 publications

Myrciaria Genus: Bioactive Compounds and Biological Activities

Myrciaria Genus: Bioactive Compounds and Biological Activities

Myrciaria dubia Juice (camu-camu) Exhibits Analgesic and Antiedematogenic Activities in Mice

Somatic Embryogenesis of Myrciaria dubia (Kunth.) McVaugh

Contact Info

Product

Resources

About