Antígenos variantes de superfície de hemácias infectadas por Plasmodium falciparum na Amazônia brasileira: aderência a receptores do endotélio vascular (CD36 e ICAM-1) e reconhecimento por anticorpos.
Abstract:Malaria is one of the major parasitic endemic diseases in Brazil with 460,000 clinically notified cases in 2007. The relative rarity of severe malaria in Brazil suggests that the local Plasmodium falciparum isolates are less virulent than African and Asian parasites. P. falciparum virulence is mainly due to its ability to adhere to the vascular endothelium receptors through variant surface antigens (VSA) exported to the infected red blood cell membrane. This work investigated adherence patterns to CD36 and ICA… Show more
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