Antigenicity of Pooled Human Malignant and Normal Tissues by Cyto-Immunological Technique: II. Nature of Tumor Antigen

Tissue Polypeptide Antigen in Normal and Neoplastic Urinary Bladder

“…It is a tumorrelated protein antigen originally obtained from carcinoma tumors [1,2], It could be considered an epithelial tissue marker and/or a differentiation mark er [3]. TPA detection in scrum and urine samples has been widely performed in cancer patients [4,6].…”

Systematic Antigenic Change in Human Carcinoma Tissues by Hemagglutination Techniques

“…Whether the previously demonstrated cytotoxity inhibition antigen of lipoprotein type [Bjorklund et al, 1958] is identical with the hem agglutination antigen cannot be stated with certainty at this time.…”

A Common Tumour Specific Antigen

“…Firstly, the lymphocyte donors have had tumours quite differently sited and histologically different from those serving as sources of antigen; secondly, the effect of the common tumour antigen (indirectly) on the macrophages seems to be maximal (Carnegie et al, 1973) and response to further antigens would produce no extra slowing. The results obtained by Bjorklund over several years (see inter alia Bjorklund and Bjorklund, 1957;Bjorklund, 1961Bjorklund, , 1968 which have very recently come to our notice, suggest that other methods of detection of a common antigen are practicable, though failure to detect such an antigen has led to the current belief that it cannot exist.…”