Antigenicity of envelop and non-structural proteins of dengue serotypes and their potentiality to elicit specific antibody

Venkatachalam, Ramesh; Vijayakumar, Sekar

doi:10.1016/s2222-1808(15)60855-6

Cited by 2 publications

(3 citation statements)

References 16 publications

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“…The extramembrane location of these proteins makes them good candidates for vaccine development. The proteins E, prM, NS1 and NS3 have been identified by VaxiJen as probable antigens [96], and several B-and T-cell epitopes have been predicted [96][97][98]. The nonstructural protein NS5 is the most conserved DENV protein making it a good vaccine target [99].…”

Section: Prediction Of Viral Immunogensmentioning

confidence: 99%

See 1 more Smart Citation

Immunogenicity Prediction by VaxiJen: A Ten Year Overview

Zaharieva¹,

Димитров²,

Flower³

et al. 2017

J Proteomics Bioinform

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Section: Prediction Of Viral Immunogensmentioning

confidence: 99%

“…The nonstructural protein NS5 is the most conserved DENV protein making it a good vaccine target [99]. It has low intrinsic antigenicity but contains several potent and promiscuous T-and B-cell epitopes [98,99].…”

Section: Prediction Of Viral Immunogensmentioning

confidence: 99%

Immunogenicity Prediction by VaxiJen: A Ten Year Overview

Zaharieva¹,

Димитров²,

Flower³

et al. 2017

J Proteomics Bioinform

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“…The structural protein of the virus X The journal homepage www.jpacr.ub.ac.id p-ISSN : 2302 -4690 | e-ISSN : 2541 -0733 102 such as envelope (E) glycoprotein of the virus membranes is the most exposed structure as principal target of neutralizing antibodies and has affects host cell receptor binding [12], [13], [14]. The glycosylation of E protein pattern differs according to DENV serotype.…”

Section: Introductionmentioning

confidence: 99%

Polytope Prediction for Dengue Vaccine Candidate Based on Conserved Envelope Glycoprotein of Four Serotypes of Dengue Virus and Its Antigenicity

Himmah

Fitriyah

Ardyati

et al. 2016

J. Pure App. Chem. Res.

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Dengue fever reported endemic in tropical and sub-tropical country. Dengue fever caused by dengue virus, has Envelope protein that often used for vaccine development to prevent the virus infection. Vaccine development to prevent four serotype dengue virus infection still unavailable. This study aims to design polytope from four conserved epitopes of dengue virus envelope glycoprotein to prevent infection of heterotypic dengue virus and predict its antigenic challenge by molecular docking. We investigate molecular modeling of polytope, immunoinformatics analysis of polytope, protein structure of antibodies, molecular docking and protein-protein docking assessment. The polytope categorized as a stabil protein with index 29.72, has molecular weight 6,139 kDa, has three exposed antigenic determinants region and has estimated half-life is: 3.5 hours (mammalian reticulocytes, in vitro),10 min (yeast, in vivo), and >10 hours (Escherichia coli, in vivo). The Polytope binds with four broadly neutralizing antibodies of B7, C8, A11, and C10 (bnAbs) which estimated that four bnAbs can recognize four serotypes of dengue virus. The designed polytope has prospect to produce in Escherichia coli and can be applied as vaccine of heterotypic dengue virus serotype. Polytope is potentially able to generate humoral and cellular immunity.

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Antigenicity of envelop and non-structural proteins of dengue serotypes and their potentiality to elicit specific antibody

Cited by 2 publications

References 16 publications

Immunogenicity Prediction by VaxiJen: A Ten Year Overview

Immunogenicity Prediction by VaxiJen: A Ten Year Overview

Polytope Prediction for Dengue Vaccine Candidate Based on Conserved Envelope Glycoprotein of Four Serotypes of Dengue Virus and Its Antigenicity

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