Antigenicity and immunogenicity of the C-terminal peptide of human thyroglobulin

A novel pathogenic peptide of thyroglobulin (2208–2227) induces autoreactive T‐cell and B‐cell responses in both high and low responder mouse strains

“…Rather it suggested strongly that p2208 is accessible on the surface of the quarternary structure of Tg by specific IgG antibodies. Similar findings have also been described for other pathogenic Tg peptides used as immunogens by other research teams . Such antibodies can be useful tools in mapping the antigenic topography of B‐cell epitopes on Tg and in the construction of diagnostic kits for the detection of Tg in serum.…”

“…Similar findings have also been described for other pathogenic Tg peptides used as immunogens by other research teams. 9,16,18,37,38 Such antibodies can be useful tools in mapping the antigenic topography of B-cell epitopes on Tg and in the construction of diagnostic kits for the detection of Tg in serum.…”

Fine epitope mapping within the pathogenic thyroglobulin peptide 2340–2359: minimal epitopes retaining antigenicity across various MHC haplotypes are not necessarily immunogenic

“…Over the last 20 years, Tg T‐cell epitopes have been mapped and used as model antigens in the study of immunoregulation of EAT. Mapping efforts used mostly HR strains (particularly H2k ), and among the 35 Tg peptides examined, 25 peptides were administered in HR strains, 6–14 six peptides in LR strains 10 and three peptides in both HR and LR strains 15,16 . The outcome of these studies was the mapping of 14 Tg peptides that induce EAT in HR strains, 7–9,11,14–17 whereas no Tg peptide was found to cause thyroiditis exclusively in LR mice.…”

“…Over the last 20 years, Tg T-cell epitopes have been mapped and used as model antigens in the study of immunoregulation of EAT. Mapping efforts used mostly HR strains (particularly H2k), and among the 35 Tg peptides examined, 25 peptides were administered in HR strains, [6][7][8][9][10][11][12][13][14] six peptides in LR strains 10 and three peptides Aikaterini Hatzioannou, 1 Maria Alevizaki, 2 George Carayanniotis 3 and Peggy Lymberi 1…”

Μελέτη Παθογενετικών Μηχανισμών Της Πειραματικής Αυτοάνοσης Θυρεοειδίτιδας

“…Δληζρχεηαη επνκέλσο ε άπνςε φηη ηα αληηζψκαηα παίδνπλ δεπηεξεχνληα ξφιν ζηελ ΔΑΣ(99). Σα εηδηθά αληηζψκαηα γηα ηέζζεξα απφ ηα παξαπάλσ πεπηίδηα [I-p117, P40, TgP1(2495-2511), hT42553] είραλ ηελ ηθαλφηεηα λα αλαγλσξίδνπλ θαη νιφθιεξν ην κφξην ηεο Tg(99,223,232,244). Σα εηδηθά παζνγνληθά πεπηίδηα ηεο Tg πνπ αλαθέξζεθαλ ζην Κεθάιαην Η 7.…”