Antigenically shielded universal red blood cells by polydopamine-based cell surface engineering

Wang, Ben; Wang, Guangchuan; Zhao, Baowei; Chen, Jiajun; Zhang, Xueyun; Tang, Ruikang

doi:10.1039/c4sc01120a

Cited by 73 publications

(66 citation statements)

References 26 publications

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“…Furthermore, surface modification can change the surface properties and create additional functionalities of the underlying material. Due to the advantages mentioned above, PDA has entered the scene of materials science in recent years, with applications that go beyond surface coatings, 8,9 into the fields of solar energy, 10 water purification, 11 shape memory polymer, 12 microrobots, 13 biomedicine, 14–16 and nanotechnology. 9,17 …”

Section: Introductionmentioning

confidence: 99%

Polydopamine and eumelanin molecular structures investigated with ab initio calculations

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Polydopamine and eumelanin molecular structures investigated with ab initio calculations

et al. 2017

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“…There are several reasons for its popularity: it is easy to prepare through dopamine (DA) self‐polymerization under slightly basic aqueous conditions, it adheres to virtually any solid material, it can be functionalized further after formation, it redox‐active and biocompatible . These properties lead to a broad spectrum of applications including surface coatings, solar energy conversion, water purification, microrobots, or nanomedicine …”

Section: Introductionmentioning

confidence: 99%

“…[5] These properties lead to ab road spectrumo fa pplications including surface coatings, [6,7] solar energy conversion, [8] water purification, [9] microrobots, [10] or nanomedicine. [11] It also meets severalc urrent environmental and economic requirements in the field of catalysis. [12] PDA is an environmentally benign material, its preparation is facile and does not require excess of hazardous reagents and it is nontoxic, bench-stable, and cheap.…”

Section: Introductionmentioning

confidence: 99%

Palladium on Polydopamine: Its True Potential in Catalytic Transfer Hydrogenations and Heck Coupling Reactions

et al. 2017

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The application of Pd–polydopamine and magnetic Fe3O4@Pd–polydopamine catalysts in catalytic transfer hydrogenation reactions and the Heck arylation is reported. The reduction of a wide range of aromatic nitro‐compounds bearing both electron‐donating and ‐withdrawing substituents to the corresponding anilines could be efficiently performed, although the reduction of carbonyl compounds was found to be less general. In the latter case, only aromatic ketones could be reduced to the corresponding alcohols, whereas aldehyde substrates were unaffected, which may be owing to their reaction with the catalyst support leading to catalyst deactivation. By using magnetic Fe3O4@Pd–polydopamine system, facilitated catalyst recovery and reuse for five consecutive cycles without considerable loss of activity in nitro‐group reduction. The efficiency of the catalyst in Heck reactions was comparable to that in transfer hydrogenation, however, no catalytic activity was observed upon reuse in this case, likely as a result of metal leaching. We also explored tandem Heck reaction/catalytic transfer hydrogenation sequences, however, the two reactions showed limited compatibility under the applied conditions.

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“…[18] Additionally, we and others have previously shown that the PD layer was mechanically durable and permselective when individual cells were coated with PD. [19] To determine the cytocompatibility of the PD coating in the current system, we obtained the colony-forming unit (CFU) for the three yeast-laden bead samples: the asprepared beads and the AL-PD and AL-CTRL beads. After bead degradation with citric acid (50 mm), serially diluted cell suspensions were spread on a synthetically defined tryptophan dropout (SD/-Trp) plate, and the cells were incubated at 30 8C for 48 hours.…”

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confidence: 99%

Cytoprotective Alginate/Polydopamine Core/Shell Microcapsules in Microbial Encapsulation

et al. 2014

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Chemical encapsulation of microbes in threedimensional polymeric microcapsules promises various applications, such as cell therapy and biosensors, and provides a basic platform for studying microbial communications. However, the cytoprotection of microbes in the microcapsules against external aggressors has been a major challenge in the field of microbial microencapsulation, because ionotropic hydrogels widely used for microencapsulation swell uncontrollably, and are physicochemically labile. Herein, we developed a simple polydopamine coating for obtaining cytoprotective capability of the alginate capsule that encapsulated Saccharomyces cerevisiae. The resulting alginate/ polydopamine core/shell capsule was mechanically tough, prevented gel swelling and cell leakage, and increased resistance against enzymatic attack and UV-C irradiation. We believe that this multifunctional core/shell structure will provide a practical tool for manipulating microorganisms inside the microcapsules.

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Antigenically shielded universal red blood cells by polydopamine-based cell surface engineering

Abstract: A strategy of surface engineering by using polydopamine was developed to shelter antigens on red blood cells and prevent coagulation reactions.

Cited by 73 publications

References 26 publications

Polydopamine and eumelanin molecular structures investigated with ab initio calculations

Polydopamine and eumelanin molecular structures investigated with ab initio calculations

Palladium on Polydopamine: Its True Potential in Catalytic Transfer Hydrogenations and Heck Coupling Reactions

Cytoprotective Alginate/Polydopamine Core/Shell Microcapsules in Microbial Encapsulation

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