Antigenic Variation of Recently Isolated A2 Influenza Viruses

Weinberger, H. L.; Buescher, Edward L.; McCown, Jack M.; Gauld, John R.

doi:10.3181/00379727-114-28693

Cited by 11 publications

(5 citation statements)

References 1 publication

(2 reference statements)

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“…Antiserums prepared against the A2/65 virus strain, however, were poor inhibitors of older A2 viruses. Weinberger and co-workers have reported similar results with their 1963 isolates (3,4). The significance of minor antigenic differences between the A2 strains is uncertain, but it is worthwhile to note the distinc tiveness of the A2/65 virus.…”

Section: Discussionsupporting

confidence: 65%

“…2 All preinoculation serum samples showed hemagglutination-inhibition titers of^8 and neutralization titers of 4; these titers were the lowest serum dilutions tested. 3 Not done. 4 Nonspecific inhibitor, which could not be removed by heat, potassium periodate, or treatment with receptordestroying enzyme.…”

Section: Resultsmentioning

confidence: 99%

“…The 1964 serums were taken in October, during the pre-epidemic period; the 1965 serums were taken in March, immediately after the epidemic 2. Patient had received 1 dose of multivalent influenza vaccine in October 1964 3. Not done.…”

mentioning

confidence: 99%

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Biological and Antigenic Characteristics of an A2 Influenza Virus Isolated in 1965: New Haven Study

Walder¹,

Hsiung²

1967

Public Health Reports (1896-1970)

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Section: Discussionsupporting

confidence: 65%

Section: Resultsmentioning

confidence: 99%

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Biological and Antigenic Characteristics of an A2 Influenza Virus Isolated in 1965: New Haven Study

Walder¹,

Hsiung²

1967

Public Health Reports (1896-1970)

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“…During the acute phase, influenza virus (A/Thai/303/68) was isolated from six of these eight individuals. Complementfixing (CF) and HI antibodies were measured in microtiter plates (Limbro Chemical, New Haven, Conn.) utilizing periodate or DEAE to remove nonspecific inhibitors (26). Neutralizing antibody was measured in primary rhesus monkey kidney cell cultures (26).…”

Section: Methodsmentioning

confidence: 99%

Method for Extracting Viral Hemagglutination-Inhibiting Antibodies from the Nonspecific Inhibitors of Serum

Altemeier¹,

Mundon²,

Top³

et al. 1970

Applied Microbiology

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Various methods are used to remove nonspecific inhibitors from sera before titering viral hemagglutination-inhibiting antibodies. These methods have several undesirable features; some are tedious and time-consuming, some remove antibody along with nonspecific inhibitors, and different techniques are usually required to remove the nonspecific inhibitors for different viruses. This communication describes a single method that uses diethylaminoethyl-Sephadex to extract the immunoglobulin G antibodies for several viruses from nonspecific inhibitors. The procedure is fast, simple to perform, and removed the nonspecific inhibitors for influenza, Western equine encephalitis, dengue-2, and rubella viruses.

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“…The first antigenic changes were noted in 1961 (Isaacs, Hart & Law, 1962) followed by reports of further differences in 1962-3 by Morris et al (1963) and Weinberger, Buescher, McCown & Gauld (1963) and in 1964 by Pereira et al (1964). The antigenic composition remained relatively stable from 1964 until 1967, when a strain was isolated in Tokyo differing recognizably from those which had circulated during the previous 3 years.…”

Section: Influenza A2 Epidemicsmentioning

confidence: 97%