Antigenic Variation of Avian Influenza A(H5N6) Viruses, Guangdong Province, China, 2014–2018

Bai, Ru; Sikkema, Reina S.; Li, Cong rong; Munnink, Bas B. Oude; Wu, Jie; Zou, Lirong; Jin, Yi; Lu, Jing; Yuan, Runyu; Liao, Ming; Ke, Changwen

doi:10.3201/2510.190274

Cited by 11 publications

(12 citation statements)

References 11 publications

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“…Our study was done retrospectively, but showed potential for early warning for vaccine escape variants or circulation of viruses with molecular markers for human infections or antiviral resistance ( Bai 2019 ). With the development of next-generation sequencing, such public health translation of pathogen genomic data can become a new routine, provided costs of sequencing and analytical processes is developed for such environments ( Aarestrup and Koopmans 2016 ; Grubaugh et al.…”

Section: Discussionmentioning

confidence: 99%

Exploring utility of genomic epidemiology to trace origins of highly pathogenic influenza A/H7N9 in Guangdong

Bai¹,

Sikkema

Munnink

et al. 2020

Virus Evolution

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The first highly pathogenic (HP) influenza A/H7N9 was reported in Guangdong in January 2017. To investigate the emergence and spread of HP A/H7N9 in Guangdong province, we sequenced 297 viruses (58 HP A/H7N9, 19 low pathogenic (LP) A/H7N9, and 220 A/H9N2) during 2016–2017. Our analysis showed that during the fifth wave, three A/H7N9 lineages were co-circulating in Guangdong: the local LP Pearl River Delta (PRD) lineage (13%), the newly imported LP Yangtze River Delta (YRD) lineage (23%), and the HP YRD lineage (64%). Previously circulating YRD-lineage LP during the third wave evolved to the YRD-lineage HP A/H7N9 in Guangdong. All YRD-lineage LP detected during the fifth wave most likely originated from newly imported viruses into Guangdong. Genotype comparison of HP A/H7N9 suggests limited outward spread of HP A/H7N9 to other provinces. The distribution of HP A/H7N9 cleavage site variants on live poultry markets differed from that found in humans, suggesting a V1-type cleavage site may facilitate human infections.

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Section: Discussionmentioning

confidence: 99%

Exploring utility of genomic epidemiology to trace origins of highly pathogenic influenza A/H7N9 in Guangdong

Bai¹,

Sikkema

Munnink

et al. 2020

Virus Evolution

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“…Therefore, validation of pooled samples or novel sample types that can be used to monitor groups or populations of humans, animals or a certain geographical area. In Asia, environmental surveillance of live animal markets is routinely implemented as main means of monitoring of Avian Influenza viruses ( Bai et al ., 2019 ; Henning et al ., 2019 ; Khan et al ., 2018 ). Various surfaces, such as poultry cages, chopping boards and defeathering machines, are sampled and tested on a regular basis as an indirect measure of poultry infections and public health risk.…”

Section: The Value Of Non-invasive and Bulk Samplesmentioning

confidence: 99%

Preparing for Emerging Zoonotic Viruses

Sikkema

2021

Encyclopedia of Virology

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“… 2 The World Health Organization estimates that China accounts for 14% and 5.1% of the global burden of H. influenzae type b infections and deaths, respectively, and 12% and 3.6% of Streptococcus pneumoniae infections and deaths, respectively. 8 – 10 It is also estimated that >80% of all rotavirus-related deaths involve children in low-income countries of South Asia and sub-Saharan Africa. 11 In China, approximately 47.8% of hospitalizations in children <5 years old are attributable to rotavirus.…”

Section: Introductionmentioning

confidence: 99%

Factors impacting self-pay pediatric vaccine utilization in China: a large-scale maternal survey

Lu²,

et al. 2020

J Int Med Res

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Objectives Utilization of self-pay vaccines worldwide is very low, especially in China; the reasons for this are unclear. We aimed to identify factors that impact the decision among Chinese mothers to utilize self-pay vaccines for their children. Methods Mothers who were hospitalized at two hospitals in Zhanjiang City and who agreed to participate by completing the required questionnaire were eligible for this study. Results In total, 7518 respondents (n = 7592) completed the questionnaire and were included in this survey. The self-pay option was largely elected by mothers with one child, compared with those who had two or more children. Similarly, utilization by workers at government agencies and organizations was higher than that among factory workers or unemployed respondents. Mothers with a college degree or above had higher utilization than those with a high school level education or lower. The main issues affecting maternal decisions to utilize self-pay pediatric vaccines were safety, the protective effect, and the high cost. Conclusion Mothers with higher socioeconomic status were more inclined to self-pay for pediatric vaccines. Steps taken to enhance public awareness about the safety and protective benefits of self-pay vaccines, as well as lowering their cost will likely encourage broader utilization of these vaccines.

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Antigenic Variation of Avian Influenza A(H5N6) Viruses, Guangdong Province, China, 2014–2018

Cited by 11 publications

References 11 publications

Exploring utility of genomic epidemiology to trace origins of highly pathogenic influenza A/H7N9 in Guangdong

Exploring utility of genomic epidemiology to trace origins of highly pathogenic influenza A/H7N9 in Guangdong

Preparing for Emerging Zoonotic Viruses

Factors impacting self-pay pediatric vaccine utilization in China: a large-scale maternal survey

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