Antigenic Properties of Staphylococcus Aureus

Oeding, Per

doi:10.1128/mmbr.24.4.374-396.1960

Cited by 16 publications

(12 citation statements)

References 70 publications

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Section: Discussionmentioning

confidence: 99%

“…The complex immunological structure of S. aureus strains has been recently reviewed by Oeding (20). It is not possible at the present time to say which, if any, of the S. aureus factors (20) is the a-acetylglucosaminyl-ribitol determinant. In addition to the teichoic acids, several capsular substances (which do not appear to be teichoic acids) in unusual strains of S. aureus have been identiffed as immunologically active materials (21,22).…”

Section: Discussionmentioning

confidence: 99%

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Chemical Basis for an Immunological Specificity of a Strain of Staphylococcus Aureus

Juergens

Sanderson

Strominger

1963

The Journal of Experimental Medicine

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The structure and biosynthesis of the cell wall of Stapkylococcus aureus, strain Copenhagen, have been investigated previously (cf. reference 1). Studies of the immunological specificity of this strain were undertaken for several reasons. The chemical nature of the surface structure (the cell wall) of this organism was under investigation and had been partially elucidated. If, as seemed likely, the ceil wall contained immunological determinants, the chemical nature of structures responsible for this activity could be defined. Relatively little is known about the chemistry of the antigens ha staphylococci or their relationship to such biological phenomena as immunity, allergy, plmgocytosis, and intracellular lysis. Moreover, it seemed likely that immunological methods would prove useful in further studies of the biosynthesis of the cell wall of S. aureus. These have been the stimuli to the present work.Rabbit anfisera were prepared against whole organisms of S. aureus, strain Copenhagen, and were found to agglutinate cell walls prepared from this species. IIspten inhibition of this agglutination has led to the conclusion that the teichoic acid (eft reference 2) in the cell wall (a polymer of ribitol phosphate which contains glycosidicaUy linked N-acetylglucosamine and esterified D-alanine) contains a serologicaily active group. Among the earliest studies of the antigens in S. aureus strains were those of Julianelle and associates (3, 4). They isolated a substance termed polysaccharide A 25 years ago and showed that it was active both in precipitin tests with rabbit antisera and in inducing wheal and erythema in humans. A similar, but distinct substance, termed polysaccharide B, was isolated from Staphylococcus aIbus strains. In retrospect the described properties, as well as the method of isolation, of polysaccharides A and B indicate that these compounds were teichoic adds. In recent years, immunological activity of the polyglycerophosphate (which belongs to the family of teichoic acids, i.e. polyol phosphate polymers) found in several Gram-positive species has been demonstrated by McCarty (5).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chemical Basis for an Immunological Specificity of a Strain of Staphylococcus Aureus

Juergens

Sanderson

Strominger

1963

The Journal of Experimental Medicine

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“…The chemical composition of the acid precipitate was suggestive of nucleoproteins. The n antigen (Haukenes & Oeding 1960) is found in the acid precipitate. Of the methods examined, disruption in the bacteria press is best suited, giving a satisfactory yield without obvious signs of degradation.…”

Section: Washing Vf Fhc Bacferiamentioning

confidence: 99%

“…The choice of strain 1503 (Oeding 1952) for the present work has two reasons. First, the strain possesses a type-specific protein antigen, the n antigen, which can easily be detected by agar precipitation (Haukenes & Oeding 1960). Second, the strain has not been found to contain type-specific carbohydrates (Oeding 1953).…”

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confidence: 99%

Extraction and Fractionation of Antigenic Material From Staphylococcus Aureus

Haukenes¹,

Losnegard²,

Oeding³

1961

Acta Pathologica Microbiologica Scandinavica

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“…

The information on the antigenic properties of Staphylococcus aureus has recently been reviewed by Oeding (10). Little is, however, known of the antigenic properties of coagulase negative staphylococci.Julianelle & Wieghard ( 6 ) reported that pathogenic and nonpathogenic staphylococci could be differentiated by means of specific carbohydrate precipitinogens which they called A and B respectively.

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mentioning

confidence: 99%