Antigenic Homology of HIV-1 GP41 and Human Platelet Glycoprotein GPIIIa (Integrin β3)

Domínguez, Victoria; Gevorkian, Goar; Govezensky, Tzipe; Rodriguez, Hector; Viveros, Monica; Cocho, G.; Macotela, Yazmín; Massó, Felipe; Pacheco, M.M; Estrada, José L.; Lavalle, C; Larralde, Carlos

doi:10.1097/00042560-199804150-00001

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…[910] It has been reported that platelet-reactive autoantibodies can also bind to the mitochondrial antigen M2(10) and dengue viral nonstructural protein 1 (NS1), which exhibits a tendency to elicit potentially hazardous antibodies thus showing a wide spectrum of specificity against extracellular matrix and platelet antigens as well. [12] These findings suggest that GT patients without a history of transfusions with blood products may produce antibodies to the platelet glycoprotein receptor IIb/IIIa, which is congenitally absent in these patients, in the same manner as anti-A agglutinin is produced in the B-positive blood group patients and anti-B agglutinin is produced in the A-positive blood group patients. For the ABO blood group system, it has been firmly established that these agglutinins, which are called natural antibodies, develop because of exposure to similar antigens in the bowel microflora of the individual.…”

Section: Resultsmentioning

confidence: 97%

“…We also looked for sequence homology between platelet membrane glycoproteins and bacterial or viral peptides. We found reports suggesting sequence homologies between the platelet membrane glycoproteins and mitochondrial antigen M2,[11] dengue viral NS1,[12] and human immunodeficiency virus-1 GP41. [13] It may not be out of place to mention here that dengue and other arbovirus infections are very common in India in addition to ubiquitous Ebstein-Barr virus and cytomegalovirus, which are known to cause immune thrombocytopenia by unknown mechanisms.…”

Section: Resultsmentioning

confidence: 99%

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Antiplatelet antibodies in cases of Glanzmann′s thrombasthenia with and without a history of multiple platelet transfusion

Ghosh¹,

Kulkarni²,

Shetty³

et al. 2009

Indian J Hum Genet

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Antiplatelet antibodies are known to be present in a wide spectrum of patients, which include chronic Idiopathic Thrombocytopenic Purpura (ITP), infections, etc., including Glanzmann's thrombasthenia (GT) patients who receive multiple platelet transfusions. The presence of natural antibodies to platelet receptors is not studied in cases of GT. We studied the antiplatelet antibodies in 23 patients with GT, 15 of which had received multiple transfusions and eight that had not received transfusions, along with 50 cases of chronic ITP. The prevalence and specificity of platelet-bound antibodies were detected by inhibition assays using O-group platelets on flow cytometry. The mean antiplatelet antibodies in 15 patients of GT who had not received transfusions and eight patients with multiple transfusions was 8427 + 2131.88 and 9038 + 2856 antibodies/platelet, respectively, while in case of the 50 ITP patients studied, it was 22166 + 5616 antibodies/platelet (Normal Range 1500–3200 antibodies/platelet). We conclude that GT patients who have not received transfusions may develop antiplatelet antibodies to the missing/abnormal receptor. Whether this is due to a molecular mimicry or due to some other mechanism needs to be explored.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Antiplatelet antibodies in cases of Glanzmann′s thrombasthenia with and without a history of multiple platelet transfusion

Ghosh¹,

Kulkarni²,

Shetty³

et al. 2009

Indian J Hum Genet

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“…In both mechanisms, subsequent clearance of the complex by phagocytic mononuclear system occurs. It has been observed that the anti-HIV-antibodies present in these patients cross-react with platelets due to homology between the gp120 and the GPIIIa (CD61) (53)(54)(55).…”

Section: Antiphospholipid and Antiplatelet Antibodies And Thrombocytomentioning

confidence: 99%

Prevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)‐infected Chilean patients

Palomo

Alarcón

Sepúlveda

et al. 2003

Clinical Laboratory Analysis

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Antiphospholipid (aPL) and antiplatelet (aPlt) antibodies, found in patients with autoimmune diseases, are also detected in infectious diseases. The purpose of this study was to examine the prevalence of these antibodies in HIV patients and to evaluate an association of these antibodies with thrombocytopenia and/or thrombosis. Sixty-three HIV-seropositive patients and 52 normal controls were studied. Anti-cardiolipin (aCL), anti-beta(2) glycoprotein I (anti-beta(2)GPI), and antiprothrombin (aPT) antibodies were determined and the lupus anticoagulant (LA) test was performed. Antiplatelet antibodies (aPlt) were also determined. Seven out of 63 (12.7%) HIV patients were positive for aCL, four of 63 (6.3%) for anti-beta(2)GPI, and five of 63 (7.9%) for aPT. No patients studied were LA positive. Six out of 63 (9.5%) patients were positive for aPlt. One of them showed weak reactivity for GPIb-IX. The platelet count of patients (202+/-63 x 10(3) platelets/microL) was significantly lower than in the controls (343+/-6 x 10(3) platelets/microL) (P<0.001). There was no correlation between the presence of aPL and/or aPlt and thrombocytopenia. Of the HIV-infected patients, 22.2% presented aPL and 9.4% aPlt antibodies. In this study, the presence of aPL and aPlt antibodies was not associated with the development of thrombosis and/or thrombocytopenia.

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“…We have found that glycopro- Table 5 The HIV-1 protein regions locally similar to other human proteins Note: as in Table 2. Table 6 Locally similar regions in HIV-1 and human proteins, whose cross-reactivity was shown experimentally tein GPIIIa of thrombocytes (region 771-780) has a pronounced local similarity to gp120 of HIV-1 ( Table 2) that can be one of factors responsible for induced thrombocytopenia (Dominguez et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…At present, many regions of virus proteins exhibiting pronounced pathogenic properties are known for HIV-1 (Albini et al, 1998;Cantalloube et al, 1994;Chen et al, 1997/98;Dominguez et al, 1998;Nardi et al, 1997). It was also shown that certain virus infections and vaccination against them cause auto-immune complications (coxsackie, vaccinia, influenza, measles, tick-borne encephalitis, etc.)…”

Section: Introductionmentioning

confidence: 99%

Exclusion of HIV epitopes shared with human proteins is prerequisite for designing safer AIDS vaccines

Maksyutov

Bachinskii

Bazhan

et al. 2004

Journal of Clinical Virology

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Antigenic Homology of HIV-1 GP41 and Human Platelet Glycoprotein GPIIIa (Integrin β3)

Cited by 12 publications

References 25 publications

Antiplatelet antibodies in cases of Glanzmann′s thrombasthenia with and without a history of multiple platelet transfusion

Antiplatelet antibodies in cases of Glanzmann′s thrombasthenia with and without a history of multiple platelet transfusion

Prevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)‐infected Chilean patients

Exclusion of HIV epitopes shared with human proteins is prerequisite for designing safer AIDS vaccines

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