Antigenic homology among coronaviruses related to transmissible gastroenteritis virus

Abstract

The antigenic homology of 26 coronavirus isolates, of which 22 were antigenically related to transmissible gastroenteritis virus (TGEV), was determined with 42 monoclonal antibodies. Type, group, and interspecies specific epitopes were defined. Two group specific MAbs distinguished the enteric TGEV isolates from the respiratory variants. An antigenic subsite involved in neutralization was conserved in porcine, feline, and canine coronavirus. The classification of the human coronavirus 229E in a taxonomic cluster distinct from TGEV group is suggested.

Field Isolates of Transmissible Gastroenteritis Virus Differ at the Molecular Level from the Miller and Purdue Virulent and Attenuated Strains and from Porcine Respiratory Coronaviruses.

“…It has been shown that PRCV strains have a large deletion in the N-terminus of the S gene. The U.S.A. and European PRCV isolates had 681 nucleotide (227aa) and 672 nucleotide (224aa) deletions, respectively [30,37,49]. However, their antigenicity was similar in studies with monoclonal antibodies [41,50].…”

“…Monoclonal antibodies against some epitopes of the S glycoprotein (antigenic site D) [4], which are absent in PRCV, could be used to distinguish between TGEV and PRCV strains [16,37,41]. Also, some probes originating from the 5' coding region of the S glycoprotein gene of TGEV only reacted with TGEV isolates [1,47].…”

Analysis of a 9.6 kb sequence from the 3' end of canine coronavirus genomic RNA

“…Likewise, TGEV can also infect other species (Woods & Pedersen 1979;Norman et al, 1970) and FIPV can infect swine (Woods et al, 1981). This close relationship indicates that the viruses may have a common ancestor (Horzinek et al, 1982;Sanchez et al, 1990).…”

“…CCV belongs to one of the major antigenic groups of coronaviruses Spaan et al, 1988) and is serologically related to feline infectious peritonitis virus (FIPV), feline enteric coronavirus (FECV), transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV) (Sanchez et al, 1990). These viruses have been distinguished mainly by their ' host species of origin.…”

Identification of antigenic sites mediating antibody-dependent enhancement of feline infectious peritonitis virus infectivity

“…Feline infectious peritonitis virus (FIPV) is a member of the Coronaviridae and is antigenically related to feline enteric coronavirus, transmissible gastroenteritis virus (TGEV) and canine coronavirus (Sanchez et al, 1990). FIPV infection produces an ultimately fatal disease called feline infectious peritonitis (FIP) in domestic and exotic cats (Barlough & Stoddart, 1990).…”