Antigenic heterogeneity of human cytotrophoblast and evidence for the transient expression of MHC class I antigens distinct from HLA-G

Expression of the parathyroid Ca(2+)-sensing receptor in cytotrophoblasts from human term placenta

“…First, there are important differences between villous cytotrophoblasts, which lie deep to the syncytial barrier between fetal and maternal circulations, and extravillous cytotrophoblasts which are bathed by maternal blood (Douglas & King 1989, Shorter et al 1993. Secondly, there are differences in the differentiation state of extravillous cytotrophoblasts which increases progressively with increasing cell size (Rachmilewitz et al 1993).…”

Gelatinase and oncofetal fibronectin secretion is dependent on integrin expression on human cytotrophoblasts

“…Thus the 0p ositive cytotrophoblasts used here represented a mixture of villous and extravillous cytotrophoblasts, whereas the 05 positive cytotrophoblasts were purely extravillous cells. The extravillous trophoblast of first-trimester anchoring villi expresses both HLA-G protein (Shorter et al, 1993) and mRNA (Chumbley et al, 1993) together with the a 5 or aî ntegrin subunits. The cytotrophoblasts located in the proximal portion of the cell columns do not express HLA-G (Shorter et al, 1993) but are 0^ positive (Korhonen et al, 1991;Damsky et al, 1992;Aplin, 1993;Burrows et al, 1993;Bischof et al, 1993).…”

Hyperglycaemia-induced subcellular redistribution of GLUT1 glucose transporters in cultured human term placental trophoblast cells

“…In the human placenta this antibody reacts only with stromal cells, macrophages, the endothelium and with the extravillous trophoblast. It does not identify villous trophoblast, which is devoid of HLA-class I antigens [15].…”